There's plenty at stake as you finalize your Week 16 Fantasy football rankings. Should you ride the hot hand with your Week 16 Fantasy football picks, play advantageous Week 16 Fantasy football matchups, or stick with players who have allowed you to reach the playoffs? On the surface, Terry McLaurin seems like a must-start on Sunday versus Philadelphia, as he is the WR4 on the season. However, McLaurin had just 10 yards the last time he faced Philadelphia and the Eagles have allowed the fewest Fantasy points to wideouts this year. Having a reliable set of Week 16 Fantasy football projections would make the decision-making process a bit easier as you formulate your Week 16 Fantasy football strategy. Before setting your Week 16 Fantasy football lineups, be sure to check out the Week 16 Fantasy football rankings from the proven computer model at SportsLine.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons, especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

The same model has a proven track record of providing Fantasy football tips, including being ahead of the curve on players like A.J. Brown, Jonathan Taylor, Derrick Henry, Christian McCaffrey, Alvin Kamara, and Jahmyr Gibbs. Anybody who banked on players like those made a run at their league title.

Now, SportsLine has simulated the entire Week 16 NFL schedule 10,000 times and released its latest Week 16 Fantasy football rankings. Head to SportsLine now to see them.

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Top Week 16 Fantasy football QB rankings

Here's a look at SportsLine's top Week 16 Fantasy football QB picks: 

1. Joe Burrow, Cincinnati Bengals: Volume certainly matters when it comes to Fantasy, and Burrow isn't getting shortchanged in that area. He leads the league in both pass attempts and completions, which has resulted in him also leading the NFL in both passing yards and passing touchdowns.

2. Josh Allen, Buffalo Bills: The clear-cut MVP favorite, Allen has been on an unprecedented stretch recently. Over his last three games, he has seven passing touchdowns, six rushing touchdowns and a receiving touchdown. With everything he's bringing to the table in terms of positive Fantasy points, he also isn't supplying any negative Fantasy points as he has zero turnovers over this run.

3. Lamar Jackson, Baltimore Ravens: The two-time MVP is coming off his sixth career game with five passing touchdowns and no picks, and now he gets to face a suddenly reeling Steelers defense. Pittsburgh has allowed seven passing touchdowns over its last three games after giving up the same number of passing touchdowns over its previous eight games. See more top QBs here.

Top Week 16 Fantasy football RB rankings

Here's a look at SportsLine's top Week 16 Fantasy football RB picks: 

1. Jahmyr Gibbs, Detroit Lions: David Montgomery (knee) is out for the season, which elevates Gibbs from being in a timeshare to the clear-cut leader of Detroit's backfield. In three games that Montgomery missed in the 2023 season, Gibbs averaged 132.3 scrimmage yards, with two total touchdowns.

2. Bijan Robinson, Atlanta Falcons: As Kirk Cousins' play has declined, Atlanta has relied more on Robinson. He has 20-plus rush attempts in four of his last five games after hitting that threshold just twice over his previous 26 games. On Sunday, he'll face a Giants defense which has allowed the fourth-most Fantasy points to opposing running backs.

3. Chase Brown, Cincinnati Bengals: Brown has performed as the RB4 over the last seven weeks, and he has both a high floor and a high ceiling. He has at least 94 scrimmage yards in six straight games, and he's scored 11 touchdowns over his last 11 contests. See more top RBs here.

Top Week 16 Fantasy football WR rankings

Here's a look at SportsLine's top Week 16 Fantasy football WR picks: 

1. Ja'Marr Chase, Cincinnati Bengals: Whenever you lead the NFL in receptions (102), receiving yards (1,413) and receiving touchdowns (15), then you naturally lead all receivers in Fantasy points as well. Chase has already racked up more Fantasy points this season than any of his three previous NFL seasons and gets to face a Cleveland defense in Week 16 that is 26th in points allowed and 30th in yards allowed.

2. Brian Thomas Jr., Jacksonville Jaguars: The rookie has continued to produce no matter who is throwing him passes, and he's had at least 86 scrimmage yards in each of his last four games. His three games with his most targets have also come over the last three weeks, so the Jags appear to be force-feeding him, which benefits whoever has him in their Week 16 Fantasy football lineups.

3. Puka Nacua, Los Angeles Rams: Only Chase has racked up more Fantasy points amongst wideouts than Nacua since Week 8. Now, he gets to face a Jets defense which has allowed three wide receivers to have at least 99 receiving yards over the last two weeks. See more top WRs here.

Top Week 16 Fantasy football TE rankings

Here's a look at SportsLine's top Week 16 Fantasy football TE picks:

1. Kittle, San Francisco 49ers: Outside of a snowstorm in a game at Buffalo, Kittle has at least 61 yards or a touchdown in every game since Week 2. Amongst tight ends this season, Kittle ranks first in receiving touchdowns, first in Fantasy points and third in receiving yards.

2. Bowers, Las Vegas Raiders: Bowers ranks fourth amongst all players in receptions (90) and first among tight ends. He'll now get to face a Jaguars defense which has allowed seven touchdowns to opposing tight ends, which is the fourth-most in the NFL.

3. Trey McBride, Arizona Cardinals: The breakout tight end has at least 70 yards in each of his last five games, and while he has just one touchdown on the season, that could change come Sunday. Arizona faces Carolina, who has given up eight touchdowns to tight ends over its last eight games. See more top TEs here.

Top Week 16 Fantasy football defense rankings 

Here's a look at SportsLine's top three Week 16 Fantasy football D/ST picks:

1. Vikings D/ST: Minnesota has the league's No. 4 scoring defense and will face a Seahawks offense that could be without starting quarterback Geno Smith. Even if Smith plays, the Seahawks struggle to protect the quarterback as just two teams have allowed more sacks than Seattle.

2. Bills D/ST: Buffalo has the league's best turnover differential, in part, due to it ranking fifth in the NFL in takeaways. It will match up against the Patriots for the first time this season on Sunday, and New England has arguably the league's worst offense. The Pats are bottom-three in both points scored and yards gained.

3. Colts D/ST: Indy may be a surprising choice for the No. 3 Fantasy defense, but when you see it's opponent, then you'll see why the Colts are ranked so high. They will host a Titans team which had six turnovers last week and has the most giveaways (29) on the season. No matter if it's Will Levis or Mason Rudolph starting for Tennessee, one shouldn't hesitate in inserting the Colts into Week 16 Fantasy football lineups. See more top D/ST here

How to get Week 16 Fantasy football rankings

Now that you know who the top three at each position are, you'll want to see the full Week 16 Fantasy football rankings from SportsLine. The model has identified a stunner in the top 10 at quarterback, and knowing who it is can give you a huge edge in your league. Head to SportsLine now to get Week 16 Fantasy football rankings

So who should you target in your Week 16 Fantasy football rankings, and which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 16 Fantasy Football rankings for every single position, all from the model that has a history of making league-winning calls, and find out.