Mariota will start Sunday's game at Atlanta.

Mariota completed 15 of 21 passes for 207 yards and a touchdown in last Sunday's 41-24 win over the Raiders, adding 40 rushing yards and a TD on six carries. He seems comfortable in Kliff Kingsbury's offense and still moves well at age 31, making him far more useful for fantasy than a typical backup QB that's filling in for an injured starter. Mariota will face one of his former teams this Sunday, after Jayden Daniels (knee) missed Friday's practice and was ruled out not long after.

Daniels (knee) has been ruled out for Sunday's game at Atlanta.

Marcus Mariota will make a second straight start, after leading the Commanders to an easy win over the Raiders last week. Daniels was a limited practice participant Wednesday and Thursday, but reporters didn't spot him at Friday's session. Earlier in the week, Daniels said he thought he could play but wasn't sure if the Commanders' medical staff would let him. His next chance will be the following Sunday, Oct. 5 in a road matchup with the Chargers.

Mayfield (biceps) will be listed as questionable for Sunday's game against the Eagles, but he's trending in the right direction to play, Greg Auman of Fox Sports reports.

After missing Wednesday's practice, Mayfield returned Thursday but wasn't seen throwing passes. He took that step Friday and apparently made it through practice without a major setback, putting him on the right side of 'questionable' ahead of a 1:00 p.m. ET kickoff this Sunday.

Daniels (knee) wasn't spotted during the initial portion of Friday's practice, Tom Pelissero of NFL Network reports.

After being limited Wednesday and Thursday, Daniels' absence from the start of Friday's session is certainly of note. If he ends up being ruled out by the Commanders on Friday or made inactive Sunday against the Falcons, Marcus Mariota would be in line to draw the Week 4 start at QB for the team.

Murray completed 27 of 41 passes for 200 yards with two touchdowns and two interceptions while adding five rushes for 41 yards in the Cardinals' 23-20 loss to the Seahawks on Thursday night.

Murray endured a difficult night despite completing a respectable 65.9 percent of his passes and throwing multiple touchdowns for the second time in four contests. The 2019 first overall pick took six sacks, and his second-quarter interception came at the Seahawks' 22-yard line to snuff out what would have been a high probability of at least three points in a game ultimately decided by a field goal. Murray did lead the Cardinals on a clutch 12-play, 57-yard march late in the fourth quarter that culminated in a seven-yard touchdown pass to Emari Demercado, but Sam Darnold and the Seahawks had just enough time to squeak out the victory. Murray takes a 6:3 TD:INT and impressive 25-148-0 rushing line over four games into a favorable Week 5 home matchup against the Titans on Sunday, Oct. 5.

Darnold completed 18 of 26 passes for 242 yards with one touchdown and no interceptions while adding one rush for 24 yards in the Seahawks' 23-20 win over the Cardinals on Thursday night. He also committed a fumble recovered by Seattle.

Darnold extended the strong start to his Seahawks tenure with his second straight interception-less game and third consecutive with at least one touchdown pass. The scoring toss came early, as he connected with AJ Barner for a 16-yard strike late in the first quarter. Darnold didn't start clicking with top target Jaxon Smith-Njigba until late in the third quarter, but he subsequently hit his No. 1 receiver for several key completions in the final period. The last of those came with 23 seconds remaining, a 22-yard connection that helped position Jason Myers for an eventual game-winning field goal. Darnold will head into a Week 5 home showdown against the Cardinals on Sunday, Oct. 5 with a 70.0 percent completion rate, a 5:2 TD:INT and 38 rushing yards on three attempts across his first four games.

Coach Kyle Shanahan told KNBR on Thursday that Purdy (left shoulder/knee) is progressing toward a return to action Sunday against the Jaguars, per Ian Rapoport of NFL Network. "I think (the toe) is feeling better each day, and if that continues he should be good on Sunday," Shanahan said.

This marks the most declarative statement from Shanahan as it pertains to Purdy's ability to return since the quarterback suffered a turf toe variant and an AC joint sprain in his left shoulder during a Week 1 win at Seattle. Purdy has ceded QB duties to backup Mac Jones (knee) the last two games, and both quarterbacks were limited in practice Wednesday and Thursday. Purdy and Jones may retain designations once the 49ers post their final Week 4 injury report Friday, but if Shanahan's most recent comments bear weight, it appears Purdy will be back under center this weekend.

Jones (knee) practiced in a limited capacity Thursday, Nick Wagoner of ESPN.com reports.

On the heels of his second start in place of Brock Purdy (left shoulder/toe) this past Sunday against the Cardinals, Jones revealed that he aggravated an existing PCL sprain in his left knee, which so far has capped his practice reps this week. Purdy himself also was limited Wednesday and Thursday, potentially setting up Friday's session to be key as coach Kyle Shanahan hones in on who will be under center Week 4 versus the Jaguars. In the aforementioned starts, Jones completed 53 of 80 passes for 563 yards, four touchdowns and one interception, rushed seven times for five yards and fumbled twice (one lost).

Purdy (left shoulder/toe) was a limited practice participant Thursday, Nick Wagoner of ESPN.com reports.

Purdy continues to string together capped sessions going back to Week 3 prep, and he even handled the first QB reps during pre-practice drills Thursday, per Matt Maiocco of NBC Sports Bay Area. Afterward, when asked if he'll start Sunday against the Jaguars, Purdy told Vic Tafur of The Athletic, "We'll see. I like where I'm at. I am felling a lot better." Purdy has missed the last two games due to a turf toe variant and an AC joint sprain in his left shoulder, and Mac Jones, who's earned a pair of spot starts in Purdy's place, is dealing with a sprained PCL of his own. Unless coach Kyle Shanahan officially names a starter for Week 4 on Friday, the decision to roll with Purdy or Jones in Week 4 may come down to Sunday's 4:05 p.m. ET kickoff.

Mayfield (right biceps) practiced in a limited capacity Thursday.

Mayfield maintained his activity level from one day prior and also was seen wearing a sleeve on his right throwing arm but not actually attempting passes Thursday, per Rick Stroud of the Tampa Bay Times. Speaking on Mayfield's preparation, offensive coordinator Josh Grizzard told Stroud, "Yeah, he was limited...he's in all, of course, all the meetings, all the walkthroughs, and he does such a good job of preparing already, a lot like, what [backup QB] Teddy [Bridgewater] was doing. Everybody's on the same page." There doesn't seem to be much worry about Mayfield's availability for Sunday's game against the Eagles, but who he may be throwing to is up in the air with Mike Evans (hamstring) expected to miss time and Chris Godwin (foot) still not cleared to return to action.