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Saquon Barkley RB | PHI
Giants' Saquon Barkley: Another limited showing
Barkley (ankle) practiced in a limited capacity Thursday, Dan Salomone of the Giants' official site reports.
Barkley continues to manage an ankle issue that sidelined him Weeks 6 through 9. Upon his return to the lineup following the team's Week 10 bye, he's earned a snap share ranging between 56 and 86 percent while averaging 16.8 touches for 70.4 yards from scrimmage per game. Barkley only scored one touchdown during that five-game stretch, so assuming he's available Sunday in Philadelphia he'll look to get back in the end zone against an Eagles defense that has allowed the 16th-most TDs (12) to running backs this season.
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Antonio Gibson RB | NE
Football Team's Antonio Gibson: Sits out second straight practice
Gibson (toe) didn't participate in Thursday's walk-through practice, John Keim of ESPN.com reports.
Gibson has been playing through a stress fracture in his shin for most of the season, but it's a toe injury that has kept him off the field for Washington's first two practices of Week 16. The 23-year-old appeared to pick up the injury during Tuesday's 27-17 loss to the Eagles, but he was able to check back into the contest and compiled 65 yards from scrimmage and a touchdown on 21 touches (15 carries, six receptions). Washington may just be exercising some extra caution with Gibson with the Football Team facing a quick turnaround for its Week 16 game in Dallas, but the running back will likely need to practice in some capacity Friday to have a chance to play Sunday. With J.D. McKissic (concussion) on injured reserve, Jaret Patterson is the next man up for touches behind Gibson in the backfield.
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James Conner RB | ARI
Cardinals' James Conner: Viewed as game-day decision Week 16
Arizona head coach Kliff Kingsbury said after Thursday's practice that Conner (heel) is considered a game-day decision as Saturday's contest against the Colts approaches, Darren Urban of the Cardinals' official site reports.
Expect Arizona to officially list Conner as questionable on its final Week 16 injury report, which will be released later Thursday. After being listed as a non-participant on practice reports Tuesday and Wednesday, Conner will likely get the same tag again Thursday, as Howard Balzer of SI.com noted that the running back wasn't taking part in the portion of the workout that was open to the media. Given the lack of practice reps this week, Conner may be trending toward sitting out or having his workload limited against Indianapolis, which would might set Chase Edmonds up for a lead role out of the backfield in his second game back from injured reserve.
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Alexander Mattison RB | MIA
Vikings' Alexander Mattison: Week 16 start on tap
Mattison is on track to serve as Minnesota's lead back Sunday against the Rams after Dalvin Cook was placed on the reserve/COVID-19 list Thursday, Chris Tomasson of the St. Paul Pioneer Press reports.
The Vikings haven't revealed whether Cook was placed on the list due to a positive test for the virus, but because he's unvaccinated, the 26-year-old running back will have to complete a five-day quarantine even if he was deemed a close contact of an infected person. If he tested positive for the virus, Cook would be subject to a 10-day quarantine, which would provide him with enough time to get cleared ahead of a Jan. 2 game against the Packers in Week 17, albeit without the benefit of any practice beforehand. In any case, since he'll be picking up at least one start sans Cook, Mattison looks like a strong lineup option in just about any fantasy format. In his prior three starts while Cook was sidelined Weeks 3, 5 and 13, Mattison played at least two-thirds of the Vikings' offensive snaps and averaged 24.3 carries, 6.0 targets and 149.3 yards from scrimmage per game while reaching the end zone twice.
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Rhamondre Stevenson RB | NE
Patriots' Rhamondre Stevenson: Not practicing Thursday
Stevenson (illness) wasn't spotted at practice Thursday, Mike Reiss of ESPN.com reports.
Stevenson missed Wednesday's session as well, so his status for Sunday's game against the Bills is worth closely monitoring. Meanwhile, fellow running backs Damien Harris (hamstring) and Brandon Bolden (knee) began the week as limited practice participants.
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Dalvin Cook RB | DAL
Vikings' Dalvin Cook: Moves to COVID-19 list, out Week 16
The Vikings placed Cook on the reserve/COVID-19 list Thursday.
Though Minnesota hasn't revealed whether Cook tested positive for the virus, Andrew Krammer of the Minneapolis Star Tribune notes that the running back has been following the NFL's protocols for unvaccinated players this season. With that in mind, he'll have to complete a five-day quarantine if he was deemed a close contact of an infected person, or a 10-day quarantine if he tested positive for the virus. That means that Cook won't be available to play for at least Sunday's game against the Rams, and he could also be at risk of missing a Week 17 matchup with Green Bay on Jan. 2 if he tested positive. Minnesota returned Alexander Mattison from the reserve/COVID-list Wednesday after he previously sat out the Vikings' Week 15 win over the Bears, so he'll likely be in line for a turn as Minnesota's lead back against the Rams.
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Anthony McFarland RB | MIA
Steelers' Anthony McFarland: Lands on COVID list
The Steelers placed McFarland (undisclosed) on the reserve/COVID-19 list Thursday.
McFarland hasn't taken the field in any of the last three games. It's not yet clear whether the 22-year-old has tested positive for COVID-19, but his status for Sunday's game against Kansas City shouldn't significantly impact Pittsburgh's offensive plans.
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Boston Scott RB | PIT
Eagles' Boston Scott: Relegated to special teams
Scott played just six snaps on special teams in Tuesday's 27-17 win over the Football Team.
Scott had seen at least 20 snaps on offense from Weeks 7 to 12 but saw just three in Week 13 and played purely special teams with Jordan Howard healthy again in Week 15. It's unlikely things change with Week 16's matchup against the Giants coming just five days later.
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Jeff Wilson RB | MIA
49ers' Jeff Wilson: In line for another start
Wilson is slated to be the 49ers' lead running back Thursday at Tennessee after Elijah Mitchell (knee) was ruled out for the contest.
Mitchell cleared the concussion protocol earlier this week, but his knee issue was bothersome enough to keep him off the practice field Tuesday and Wednesday and on the sideline for a third straight game. Wilson has taken on a majority share of the running back reps in the meantime, racking up 36 touches for 175 yards from scrimmage and one rushing TD. JaMycal Hasty is the only other RB on the active roster, but wide receiver Deebo Samuel and even fullback Kyle Juszczyk are likelier options to earn touches out of the backfield behind Wilson.
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Alex Armah FB | WAS
Alex Armah: Back with practice squad
Armah reverted to Washington's practice squad Wednesday.
Armah was elevated to Washington's active roster for Week 15, as the team was thin on tight end depth. Although Armah didn't see the field, it seems that the full-back has earned the now third-string tight end role with Washington. Expect Armah to get elevated again if John Bates or Ricky Seals-Jones face any injuries.