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Clyde Edwards-Helaire RB | KC
Chiefs' Clyde Edwards-Helaire: Active in Week 11
Edwards-Helaire (knee) is active for Sunday's game against the Cowboys, Adam Teicher of ESPN.com reports.
Edwards-Helaire was activated from injured reserve Saturday after a stint that led to a total of five absences, and the second-year back officially will make his return to game action Sunday. How much work Edwards-Helaire splits with Darrel Williams remains to be seen, however, considering the Chiefs may opt to ease CEH back into action after a relatively long layoff and also keep the latter involved after he performed well as both a runner and receiver over multiple games in recent weeks.
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Royce Freeman RB | CHI
Texans' Royce Freeman: Not ready for game action
Freeman (coach's decision) is inactive for Sunday's contest against the Titans, Brooks Kubena of the Houston Chronicle reports.
Freeman was claimed off waivers by Houston on Nov. 9, joining his third team this season. The Texans were on a bye during Week 10, so the matchup against Tennessee would've been his first chance to suit up for Houston. However, he apparently isn't ready for game action, which means David Johnson, Rex Burkhead and Phillip Lindsay will continue to share the workload against the Titans on Sunday.
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La'Mical Perine RB | PIT
Jets' La'Mical Perine: Healthy scratch again
Perine (coach's decision) is inactive for Sunday's game against the Dolphins, Rich Cimini of ESPN.com reports.
Perine will be in street clothes for the second straight week following Tevin Coleman's recent return from a hamstring injury. The Jets are likely to continue keeping only three running backs active on game days, and Perine will be fourth in the pecking order so long as Michael Carter, Ty Johnson and Coleman are all healthy.
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Kenneth Gainwell RB | TB
Eagles' Kenneth Gainwell: Healthy scratch Sunday
Gainwell (coach's decision) is inactive Sunday against the Saints.
Gainwell will be the odd man out with the return of Miles Sanders (ankle) from injured reserve. After Gainwell carved out a solid change-of-pace role in the Eagles offense to begin the campaign, the absence of Sanders for the past three contests didn't result in any increase in the rookie's usage. Instead, more opportunities became available for Jordan Howard and Boston Scott, who performed well enough to move ahead of Gainwell on the depth chart.
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Marlon Mack RB | ARI
Colts' Marlon Mack: Healthy scratch Sunday
Mack (coach's decision) is inactive for Sunday's game at Buffalo.
It's the third straight game Mack has been made a healthy scratch. Deon Jackson will be the available depth running back behind Jonathan Taylor and Nyheim Hines.
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Latavius Murray RB | BUF
Ravens' Latavius Murray: Suits up Sunday
Murray (ankle) is listed as active for Sunday's game against the Bears.
Murray, who last suited up in Week 6, will rejoin the Ravens' backfield Sunday and in doing so figures to work in a time-share with Devonta Freeman, with Ty'Son Williams on hand in reserve. It's a context that makes Murray a hit-or-miss Week 11 fantasy lineup option while coming off a three-game absence, though with Lamar Jackson (illness) unavailable Sunday and Tyler Huntley slated to draw the start at QB for the Ravens, a run-heavy approach could be on tap for the team.
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Damien Williams RB | ARI
Bears' Damien Williams: Won't suit up Sunday
Williams (calf/knee) is inactive for Sunday's game against the Ravens.
After putting in a pair of full practices to close out Week 11 prep, Williams looked to have moved past his left knee injury, but a newer calf concern looks to be at the root of why the Bears downgraded him to doubtful Saturday. With Williams sidelined for the third time in the Bears' last five games, Khalil Herbert will operate as the clear No. 2 option out of the backfield behind starter David Montgomery.
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James Robinson RB | NO
Jaguars' James Robinson: Ready to face 49ers
Robinson (heel/knee) is officially active for Sunday's game against San Francisco.
Robinson was officially questionable for Sunday's contest, though it's not a major surprise he's suiting up after Ian Rapoport of NFL Network reported in the early morning that the tailback was on track to play. Robinson returned from a one-game absence last week and had 12 carries for 57 yards and a touchdown while catching four of five targets for 27 yards versus the Colts.
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Elijah Mitchell RB | PHI
49ers' Elijah Mitchell: Inactive in Week 11
Mitchell (finger) is listed as inactive Sunday in Jacksonville, Keiana Martin of the 49ers' official site reports.
Mitchell emerged from Week 10 action against the Rams with a broken finger on his right hand that required surgery Tuesday. There was some optimism at the time that the rookie sixth-rounder would be available Sunday, but Mitchell didn't practice Wednesday through Friday and entered the weekend as doubtful to suit up. With his status for Week 11 now confirmed, the 49ers backfield will be down both Mitchell and JaMycal Hasty (ankle), leaving Jeff Wilson, Trey Sermon, Trenton Cannon and Kyle Juszczyk as the team's options at running back.