Dobbins rushed 20 times for 79 yards and a touchdown and brought in his only target for five yards in the Broncos' 21-17 win over the Eagles on Sunday.

Dobbins remained the clear lead back, with rookie RJ Harvey logging only four carries. The former toughed out a difficult matchup on the ground, with his long run on the afternoon a modest 17 yards. Dobbins recorded his fourth rushing touchdown in five games on a two-yard run early in the fourth quarter, while his yardage total was his third highest of the campaign and fourth over 75 yards already in 2025. Dobbins has played a minimal role in the passing game so far, but his secure role in the ground attack gives him an appealing fantasy floor heading into a favorable Week 6 matchup in London against the Jets next Sunday.

Dowdle rushed 23 times for 206 yards and a touchdown and brought in three of four targets for 28 yards in the Panthers' 27-24 win over the Dolphins on Sunday.

Stepping into the lead-back role in place of Chuba Hubbard (calf), Dowdle exceeded all expectations in his first opportunity to helm the ground attack in Carolina. Dowdle repeatedly knifed the Dolphins' front seven for big gains, including 43- and 53-yard scampers. Dowdle's otherworldly performance raises an intriguing dilemma for head coach Dave Canales whenever Hubbard is healthy again, but the Panthers can certainly afford to give the latter time to fully heal, especially with Dowdle next getting a crack at the inconsistent defense of his former Cowboys squad in a Week 6 home matchup.

Achane rushed 10 times for 16 yards and brought in six of seven targets for 30 yards and a touchdown in the Dolphins' 27-24 loss to the Panthers on Sunday.

Achane came into the interconference battle with elevated expectations, considering the struggles of the Panthers against the run and the fact Tyreek Hill's (IR, knee) absence was expected to open up even more pass-catching opportunities for the versatile back. The latter partly did come to fruition, as Achane recorded his third-highest reception and target tallies of the season and salvaged his fantasy day with an impressive 10-yard touchdown catch on the first play of the second quarter. However, the speedy back was surprisingly stymied on the ground, leading to a season-low rushing yardage total. Achane's chances of a rebound Week 6 are kind of bleak as well, considering he'll face off with a talented Chargers defense in South Florida.

Jeanty rushed 14 times for 67 yards and brought in five of seven targets for 42 yards in the Raiders' 40-6 loss to the Colts on Sunday.

Jeanty ultimately saw his rushing workload somewhat curtailed due to the game getting completely away from the Raiders, but the talented back was impressive again with the opportunities he did see. Those touches helped net new single-game career highs in receptions, receiving yards and targets for the rookie first-round pick, who corroborated the value of keeping him involved in the game even when Las Vegas is on the wrong end of a lopsided score. Jeanty will remain a highly appealing option in all formats in an enticing Week 6 home matchup against the Titans next Sunday afternoon.

Henry rushed the ball 15 times for 33 yards and a touchdown in Sunday's 44-10 loss to the Texans. He did not catch his only target.

Henry predictably couldn't find much rushing room with Cooper Rush under center, with his longest gain of the day going for seven yards. He managed to avoid complete disaster by scoring a one-yard touchdown late in the third quarter, but he's now been held to 50 rushing yards or fewer in four of five games to begin the season. Henry's outlook in Week 6 will be highly dependent on Lamar Jackson's (hamstring) availability, but he has another tough matchup against the Rams.

Barkley rushed six times for 30 yards and brought in all three targets for 58 yards and a touchdown in the Eagles' 21-17 loss to the Broncos on Sunday.

Barkley's extremely sparse rushing volume was especially alarming considering game script never dictated that the Eagles turn away from the run. The reigning Offensive Player of the Year only salvaged his fantasy day with an impressive 47-yard touchdown grab to cap off the opening possession of the second half, and his carry total was his first in single digits in a non-injury-shortened game since Week 15 of the 2023 season while he was still with the Giants. Barkley's receiving score was his first trip to the end zone in a pass-catching capacity this season, and an atypically rested Barkley should be set for much more work in a Week 6 road matchup against his old New York teammates on Thursday night.

Taylor rushed 17 times for 66 yards and three touchdowns and brought in three of four targets for 20 yards in the Colts' 40-6 win over the Raiders on Sunday. He also recovered a fumble.

Taylor encountered plenty of resistance from the Raiders defense on many of his runs, but he found enough running room to record scoring rushes of three, one and six yards, as well as a game-long 16-yard scamper. It was Taylor's second three-touchdown tally of the season, a two-game sample that accounts for all his end-zone trips to date. The sixth-year pro remains the component around which the Colts' prolific offense revolves, and Taylor should be very busy once again in a Week 6 home interconference clash with the Cardinals next Sunday.

Hall carried the ball 14 times for 113 yards and caught four of five targets for 42 yards in Sunday's 37-22 loss to the Cowboys.

The running back briefly left the game in the first half after fumbling in the red zone late in the second quarter, but Hall returned in the second half and racked up some big yardage once again in a losing effort. The 113 rushing yards were a season high for the fourth-year RB, as were the 42 receiving yards, but he's still looking for his first touchdown of 2025 -- something he came agonizing close to in the fourth quarter, when he was tackled just short of the goal line on a 16-yard reception. Hall will look to get into the end zone in Week 6 against a Broncos defense that just gave up a 47-yard receiving TD to Saquon Barkley, but otherwise held him in check.

Williams carried the ball 16 times for 135 yards and a touchdown and added a four-yard receiving TD while catching one of two targets in Sunday's 37-22 win over the Jets.

The former Bronco is having a breakout campaign in Dallas. Williams recorded his first triple-digit rushing performance since Week 13 of his rookie season in 2021, and his first receiving score since Week 10 of 2023, in Sunday's victory. He's now found the end zone six times in his first five games as a Cowboy while racking up 525 scrimmage yards, giving him massive momentum heading into a Week 6 clash with the Panthers.

Spears (ankle) is listed as active for Sunday's game against the Cardinals.

Spears, who was sidelined for the first four weeks of the season due to a high right-ankle sprain that he suffered Aug. 9, was activated from IR on Saturday after being limited in practice all week and carried a 'questionable' tag into Sunday's contest. It remains to been how much volume he'll see in his return to Tennessee's backfield, but either way, his presence figures to allow the team to spell fellow RB Tony Pollard more often going forward. During the 2024 regular season, Spears recorded 84 carries for 312 yards and four TDs and 30 catches (on 35 targets) for 224 yards and a score in 12 games, while Pollard logged 260 carries and 41 catches in 16 contests.