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Mark Walton RB | MIA
Dolphins' Mark Walton: Outgains Drake
Walton gained 32 yards on six carries during Sunday's 17-16 loss to Washington, adding 43 yards on five catches.
Walton's 11 touches Sunday were just two fewer than his previous season total. He delivered with the added exposure, picking up gains of at least 10 yards on four touches on this way to 75 total yards, a career high and five better than starter Kenyan Drake. Should Walton continue to get a larger share of carries, he'll face a tough challenge in Week 7 against division rival Buffalo.
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Kenyan Drake RB | GB
Dolphins' Kenyan Drake: Gains 70 yards
Drake ran for 40 yards on 10 carries and added 30 yards on six catches during Sunday's 17-16 loss to Washington.
Following a late touchdown, the Dolphins and quarterback Ryan Fitzpatrick placed a lot of faith in the third-year back, targeting him for what would have been a game-winning two-point conversion. It wasn't to be, and Drake remains scoreless on the season. In a season with few highlights, Drake has managed to total at least 70 yards in three consecutive games, but he actually ended up with fewer yards than backup Mark Walton on Sunday. Both will be challenged by a stout Buffalo defense Sunday.
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Miles Sanders RB | DAL
Eagles' Miles Sanders: Excels as receiver in loss
Sanders rushed three times for six yards but secured all three targets for 86 yards and a touchdown in the Eagles' 38-20 loss to the Vikings on Sunday.
Sanders was the surprise receiving yardage leader on the day for the Eagles, with a game-long 45-yard reception and a 32-yard touchdown grab serving as the highlights of his afternoon. The rookie has seen fewer opportunities on the ground than backfield mate Jordan Howard, but he clearly carries more big-play potential overall. Whether that will translate to more rushing touches in a Week 7 divisional battle against the Cowboys remains to be seen, but Sanders has now broken the ice in terms of touchdowns, as Sunday's trip to the end zone was his first as a pro.
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Alexander Mattison RB | MIA
Vikings' Alexander Mattison: Career-best production in win
Mattison rushed 14 times for 63 yards and lost a fumble in the Vikings' 38-20 win over the Eagles on Sunday.
The rookie actually outpaced Dalvin Cook in rushing yardage and had just two fewer carries, as game script was favorable to the running game for large portions of the contest. Mattison did have a trademark mixed bag of a performance for a first-year player, thrilling with a 35-yard scamper but also turning the ball over on a fumble late in the fourth quarter deep in Philadelphia territory. Mattison will look to build on his career-best day versus the Lions in a Week 7 divisional matchup.
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Dalvin Cook RB | DAL
Vikings' Dalvin Cook: Finds end zone in tough matchup
Cook rushed 16 times for 41 yards and a touchdown and secured both of his targets for 13 yards in the Vikings' 38-20 win over the Eagles on Sunday.
Cook was stymied by Philadelphia's virtually impenetrable defensive front to the tune of 2.6 yards per rush, but he still found his way into the end zone for the sixth time this season on a one-yard touchdown run in the fourth quarter. He's actually averaged under 3.0 yards per carry in two of his last three games, the byproduct of running into two of the stingiest run defenses in the NFL in the Bears and Eagles. That said, he's been spectacular overall and remains an elite play in all formats heading into a Week 7 divisional showdown versus the Lions.
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Nick Chubb RB | HOU
Browns' Nick Chubb: Rumbles for 122 yards, two scores
Chubb rushed 20 times for 122 yards and two touchdowns and caught five of six targets for 17 yards in Sunday's 32-28 loss to the Seahawks.
Chubb scored on a seven-yard run on the Browns' opening drive, and a major chunk of Chubb's yardage came two drives later when he ripped off a 52-yard run in the first quarter, setting up a 31-yard touchdown catch by Ricky Seals-Jones. His impressive day was topped off when the Browns took over on the Seahawks' 24-yard line after an errant punt. Chubb received the ball on two straight plays, rushing twice for 28 yards and a score. That gave the Browns the lead in the fourth quarter, but the Seahawks scored again and ended up with the win. Chubb's effectiveness remains impressive, as this was the third time in four games he recorded at least 100 scrimmage yards, and the one game he failed to do so, he finished with 99 yards.
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Latavius Murray RB | BUF
Saints' Latavius Murray: Logs 11 touches in win
Murray rushed eight times for 44 yards and secured all three targets for 35 yards in the Saints' 13-6 win over the Jaguars on Sunday.
Murray was set for a potential lead-back role Sunday before Alvin Kamara was declared active despite his ankle injury, but Murray ended up seeing a solid workload anyhow. The veteran back also had a touchdown reception called back due to penalty, but he still finished with season highs in rushing and receiving yardage. Murray will look to help ease Kamara's workload again Week 7 against the Bears, another game where he might see an uptick in touches with the Saints' starting back now also dealing with a knee issue suffered against Jacksonville.
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Joe Mixon RB | HOU
Bengals' Joe Mixon: Frustrating 2019 continues
Mixon managed only 10 yards on eight carries, while catching two of three targets for 29 receiving yards during Sunday's 23-17 loss to the Ravens.
The third-year back has been largely inefficient as a rusher, and his passing game involvement has not been anywhere near a level that would justify his average draft position as a top-10-to-15 running back. Behind a banged-up Bengals' offensive line, he has been held to fewer than 1.7 yards per rush in three of his six appearances, and he is averaging fewer than 17 receiving yards per game thus far in 2019. In Week 7, he and the Cincinnati front will be going up against a Jaguars defense that contained top Saints' backs Alvin Kamara and Latavius Murray to a combined 75 rushing yards on 19 attempts Sunday.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Toughs out injuries in win
Kamara rushed 11 times for 31 yards and brought in seven of eight targets for 35 yards in the Saints' 13-6 win over the Jaguars on Sunday. He also fumbled once, but it was recovered by New Orleans.
Kamara came into the contest nursing an ankle issue and then suffered an in-game knee injury as well, Amie Just of The New Orleans Times-Picayune reports. While battling those issues, the versatile back finished with pedestrian production overall, although he did enjoy a serviceable line from a PPR standpoint in particular. Kamara checked in second only to Michael Thomas in receptions for the day, and he'll now try to heal up in time for what should be a bruising matchup versus the Bears in Week 7.
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John Kelly RB | CLE
Rams' John Kelly: Suiting up Sunday
Kelly is officially active for Sunday's game against the 49ers, Cameron DaSilva of USA Today reports.
Kelly received a promotion from the practice squad to the 53-man roster Saturday in light of Todd Gurley (quadriceps) missing the game. Kelly will be the team's third-string running back for Week 6, and possibly could see reps behind rather unproven options in Malcolm Brown and Darrell Henderson.