Williams rushed the ball 17 times for 66 yards in Sunday's 33-19 win over the Titans. He added two receptions on two targets for 13 yards.

Williams dominated touches out of the Rams' backfield for the most of the game, but he was inefficient once again. He delivered 12- and 15-yard rushes late in the fourth quarter to salvage his day, but that came one drive after he ceded a possession to Blake Corum that concluded with Corum in the end zone. Corum's opportunity was likely due to the Rams being up two scores midway through the fourth quarter, but Williams' usage in the red zone will remain worth monitoring.

Kamara carried the ball 21 times for 99 yards and caught all six of his targets for 21 yards in Sunday's 26-21 loss to the 49ers.

After needing a touchdown to salvage his Week 1 performance, Kamara topped 100 scrimmage yards for the first time in 2025 in Week 2. The veteran RB needed volume to get there though, as his longest run went for only 15 yards. Kamara remains the centerpiece of the Saints' offense under new head coach Kellen Moore, and he could have a big day through the air in Week 3 against a Seahawks defense that has given up 159 combined receiving yards to the Steelers' Jaylen Warren and the 49ers' Christian McCaffrey to begin the season.

Charbonnet rushed 15 times for 10 yards and wasn't targeted in Sunday's 31-17 win over the Steelers.

Charbonnet was outplayed by Kenneth Walker, who turned 14 touches into 118 scrimmage yards and a touchdown. The 2022 and 2023 second-round draft picks have been deployed in a near-even split to begin the 2025 campaign. Seattle will likely continue to ride the hot hand in Week 3 against the Saints, though the workload could start to shift away from Charbonnet if Walker continues to outplay him.

Walker rushed 13 times for 105 yards and a touchdown while catching his only target for 13 yards in Sunday's 31-17 win over the Steelers.

Walker was far more effective than Zach Charbonnet, who had just 10 rushing yards on 15 carries. The former put an exclamation point on the win by breaking free for a 19-yard touchdown run with 3:41 left in the fourth quarter. Walker had just 24 scrimmage yards and was outplayed by Charbonnet in Seattle's Week 1 loss to the 49ers, so they will likely continue to operate in a timeshare in Week 3 against the Saints, though the workload distribution could start to tilt in Walker's favor after his strong Week 2 performance.

Achane rushed 11 times for 30 yards and brought in eight of 10 targets for 92 yards and a touchdown in the Dolphins' 33-27 loss to the Patriots on Sunday.

The Dolphins were already down 12-0 at the end of one quarter, which immediately put Achane in catch-up mode when it came to consistent rushing opportunities. As his final line indicates, those remained relatively sparse overall, but game script did work in his favor when it came to his pass-catching role. Achane finished as the Dolphins' leader in both receptions and targets, while finishing second to only Tyreek Hill in receiving yards. Achane also went in for his second receiving touchdown in as many games to open the season when he recorded an impressive 29-yard grab late in the first half, and he'll be slated for a key two-way role again during what is already essentially a must-win scenario for the Dolphins in a Week 3 Thursday night road matchup against the Bills.

Etienne rushed 14 times for 71 yards and brought in two of three targets for 18 yards and a touchdown in the Jaguars' 31-27 loss to the Bengals on Sunday.

Etienne went a long way toward proving his breakout Week 1 performance was no fluke, as he averaged 5.1 yards per carry while comfortably pacing the Jaguars in rush attempts and rushing yards. The versatile veteran also made his mark as a receiver via an 11-yard touchdown catch with just over four minutes remaining in the third quarter, his first score of any kind in the new season. With ex-backfield mate Tank Bigsby now in Philadelphia, Etienne looks entrenched as the clear-cut No. 1 back in head coach Liam Coen's productive offense going into a Week 3 home divisional matchup against the Texans next Sunday.

Brown recorded 16 rushes for 47 yards in Sunday's 31-27 win over the Jaguars. He added two receptions on three targets for 18 yards.

Brown was the only Bengals running back to record a carry for the second straight game to begin the season. However, he was also extremely inefficient once again, averaging only 2.9 yards per attempt with a long of just 11 yards. This performance was a bit more justifiable, as Jake Browning entered the game halfway through the second quarter after Joe Burrow (toe) was sidelined, allowing the Jaguars to focus on short areas of the field defensively. The Bengals don't have strong alternatives to Brown for carries, but he now has only 90 rushing yards on 37 attempts across the first two games of the campaign.

Gibbs rushed 12 times for 94 yards and a touchdown and brought in all three targets for 10 yards in the Lions' 52-21 win over the Bears on Sunday.

Although Jared Goff and Amon-Ra St. Brown mostly stole the show in Detroit's jaw-dropping offensive breakout, Gibbs rather quietly put together a fruitful fantasy performance. The dynamic back outpaced David Montgomery by one carry and 37 rushing yards, with Gibbs' game-long 42-yard scamper the big difference between the two backfield mates. Gibbs also recorded his first rushing touchdown of the season on a six-yard run in the first quarter, which served to round out his production on a day where he was limited to a mid-level workload. Gibbs will look to navigate a particularly challenging matchup when the Lions travel to Baltimore to face the Ravens in a Week 3 Monday night showdown on Sept. 22.

Henry rushed 11 times for 23 yards and wasn't targeted during the Ravens' 41-17 win over the Browns on Sunday. He also committed a fumble recovered by Baltimore.

The offense ran through Lamar Jackson and his pass catchers Sunday, as the star signal-caller finished with four touchdown passes and turned in a turnover-free performance. In contrast, Henry was consistently bottled up, and considering eight of his yards came on one carry, he truly found next to no running room throughout the afternoon. After a spectacular first three-plus quarters of the new season, Henry's fortunes have taken a turn for the worse beginning with his critical fumble in the final quarter of the Week 1 loss to the Bills. His next opportunity to reverse course will come in a Week 3 home interconference clash against the Lions on Monday night, Sept. 22.

McCaffrey carried the ball 13 times for 55 yards and caught six of seven targets for 52 yards and a touchdown in Sunday's 26-21 win over the Saints.

With the 49ers' offense missing a number of key players, including Brock Purdy (toe/shoulder), George Kittle (hamstring) and Brandon Aiyuk (knee), McCaffrey put the team on his back and carried it to a second straight victory to begin the season. His seven-yard TD reception from Mac Jones just before halftime was McCaffrey's first score of the year, but he's topped 100 scrimmage yards in both of the Niners' games so far. In Week 3, he'll take aim at a Cardinals defense he didn't face during an injury-plagued 2024, but which he lit up for an incredible 364 combined yards and seven total touchdowns in their two 2023 meetings.