VanSumeren has been ruled out for the remainder of Thursday's contest against the Cowboys after suffering a knee injury, Mike Garafolo of NFL Network reportss.

VanSumeren went down with an injury on the opening kickoff, which is now understood to be a knee issue. The fullback may be facing a prolonged absence, and more information on his status will likely come in the near future.

James (finger) was a limited participant in Thursday's practice.

James broke his finger in early August and has been a limited participant in each of the first two practices of the week. The rookie fifth-rounder figures to see minimal work out of the backfield this season. However, with Christian McCaffrey popping up on Thursday's injury report due to a calf injury, James could be thrust into the RB3 role behind Brian Robinson and Isaac Guerendo (shoulder) if McCaffrey is unable to play in Sunday's regular-season opener against the Seahawks.

McCaffrey was limited at Thursday's practice due to a calf injury, Cam Inman of The San Jose Mercury News reports.

McCaffrey's sudden appearance on the 49ers' Week 1 practice report with the same listed health concern that eventually resulted in a diagnosis of Achilles tendinitis and eight games missed to begin last season isn't a great sign. While the team may merely be managing his workload, his status now will be one to monitor closely ahead of Sunday's game at Seattle. With rookie Jordan James (finger) dealing with an injury as well, Brian Robinson and Isaac Guerendo are the current healthy running backs on San Francisco's active roster.

Sanders, Javonte Williams and FB Hunter Luepke will serve as the Cowboys' backfield options Thursday in Philadelphia with rookie Jayden Blue (coach's decision) inactive, Calvin Watkins of The Dallas Morning News reports.

Sanders and company thus won't have to yield reps to Blue, a rookie fifth-round pick, to begin the season, but ultimately the breakdown of reps between Sanders, Williams and Luepke remains to be seen. In his only appearance of the preseason, Sanders mustered 15 yards on seven carries, and he's coming off a career-low 205 rushing yards in 11 regular-season games with the Panthers in 2024, so he doesn't seem to have much fantasy utility unless he receives a significant number of touches.

Blue (coach's decision) is listed as inactive for Thursday's game at Philadelphia.

Blue emerged from the Cowboys' preseason finale with a low-ankle sprain, but it wasn't serious enough to cause the team to list him on its Week 1 injury report. Nonetheless, his pro debut will be delayed until at least Week 2 against the Giants on Sunday, Sept. 14, while Javonte Williams and Miles Sanders handle the backfield work Thursday.

Scott (ankle) did not participate in Thursday's practice.

Scott is nursing an ankle injury that he suffered during the Vikings' preseason finale against the Titans. He'll have two more chances to return to practice and give himself a shot at playing in Monday's regular-season opener against the Bears.

Chargers head coach Jim Harbaugh told Rich Eisen in a pre-broadcast meeting that Hampton is in line to draw the start over fellow running back Najee Harris in Friday's game against the Chiefs in Sao Paulo, Brazil, Alex Insdorf of BoltBeat.com reports.

Even though the Chargers invested a first-round pick in him in April's draft, Hampton was initially expected to open the season in the No. 2 role behind Harris, who signed with Los Angeles in March following four consecutive 1,000-yard rushing campaigns in Pittsburgh to begin his career. However, after Harris suffered a superficial eye injury in a Fourth of July fireworks accident that kept him from practicing throughout training camp and the preseason, Hampton was able to pick up extended reps with the first-team offense and is now poised to take the field for the Chargers' first snap of 2025. Despite his designation as the Week 1 starter, however, Hampton won't necessarily be guaranteed a three-down workload, as Harris gained clearance for the season opener following three consecutive full practices this week. Per Eric Smith of the Chargers' official site, Harbaugh wasn't willing to go into specifics Wednesday regarding how the snaps and touches might be distributed between Hampton and Harris, though Hampton likely projects as the more reliable option of the two in fantasy lineups since he's been able to get more reps under his belt throughout the summer. A clearer idea regarding the weekly workload breakdown between the two backs may not become apparent until after a few games, when Harris should be fully reconditioned and free of limitations stemming from the eye injury.

Achane (calf) was limited in practice Thursday, David Furones of the South Florida Sun Sentinel reports.

Achane has now officially been limited in back-to-back practices, though he said Wednesday that he feels 100 percent healthy and that the recent cap on his reps has simply been an effort not to aggravate his calf injury. The third-year pro appears on track to suit up for Sunday's regular-season opener against the Colts, though Furones reports that the Dolphins may opt to lean on big-bodied rookie Ollie Gordon in Week 1, and relegate the undersized Achane to a smaller workload than usual as he works to return from injury. Coach Mike McDaniel declined to offer an estimation of how the Dolphins' backfield reps will be divvied up Week 1, but whether or not Achane is able to upgrade to full participation at Friday's practice could be telling.

Harris (eye) doesn't have an injury designation for Friday's game against the Chiefs in Sao Paulo, Brazil, Eric Smith of the Chargers' official site reports.

Head coach Jim Harbaugh said Wednesday that Harris was on track to play in the season opener, and after the running back logged three consecutive full practices this week, Harbaugh's prediction has now come to pass. Per Smith, Harbaugh wasn't willing to go into specifics regarding how extensively Harris might be used Friday, though he told Rich Eisen of ESPN in a pre-broadcast meeting that rookie first-round pick Omarion Hampton would draw the start over Harris, according to Alex Insdorf of BoltBeat.com. Harris is still expected to have a role in the Chargers' game plan, but the uncertainty of his snap and touch counts after he missed all of training camp and the preseason while recovering from a superficial eye injury make it difficult to depend on him as an option in Week 1 fantasy lineups.

Johnson (foot) was listed as a non-participant on Thursday's practice estimate.

Johnson sat out the Bears' entire preseason slate due to a foot injury, and his listed DNP on Thursday may be an ominous sign for his availability Week 1 and potentially beyond that point. He'll have two more opportunities to mix into drills ahead of Monday's game against the Vikings, but even if he's able to suit up, he may remain a distant third for reps out of Chicago's backfield behind D'Andre Swift and rookie seventh-rounder Kyle Monangai (hamstring), the latter of whom was tagged as limited Thursday.