Davis (concussion) will not practice Wednesday, Zack Rosenblatt of The Athletic reports.

Davis remains in the concussion protocol after being injured in Sunday's loss to the Patriots. Kene Nwangwu and Khalil Herbert would be options to handle backup duties behind Breece Hall against the Bills if Davis is unable to play.

Chestnut played all 20 of his snaps on special teams in Sunday's 34-26 loss to the Saints.

Chestnut has been active for all 16 of the Titans' games to date but has remained an afterthought on offense when Tennessee has had both Tony Pollard and Tyjae Spears available out of the backfield. For the season, Chestnut has logged just 11 carries (for 40 yards) and has drawn just two catchless targets.

Mullings gained four yards on his lone carry in Sunday's 34-26 loss to the Saints.

Mullings took the field for the just one of the Titans' 74 snaps on offense in the loss, carrying the ball on the final play of the game as Tennessee wound out the clock. Since being activated from injured reserve in late November, the rookie sixth-round pick out of Michigan has suited up in six straight games but has logged just three carries for seven yards. He's seen most of his playing time on special teams while Tony Pollard and Tyjae Spears have worked ahead of him at running back.

San Francisco general manager John Lynch said Wednesday that McCaffrey (back) is trending in the right direction to play Saturday against the Seahawks, Cam Inman of The San Jose Mercury News reports.

McCaffrey could not practice Tuesday due to back stiffness, leaving him two more opportunities to retake the practice field in advance of Saturday night's showdown against Seattle, the winner of which will clinch the NFC West title and the No. 1 playoff seed in the NFC. The 49ers may in part simply be taking a cautious approach to McCaffrey's health due to both his importance as the focal engine of the team's offense and the fact that he's handled 20-plus touches in five consecutive games. McCaffrey previously played through this back injury early December, but he hadn't been listed on San Francisco's injury reports in Week 16 and Week 17.

Ouzts went without a target or carry while playing 14 of the Seahawks' 66 snaps on offense in Sunday's 27-10 win over the Panthers.

Ouzts was a healthy inactive for the Seahawks' Week 15 win over the Colts, but he's otherwise suited up for every contest since Seattle's Week 8 bye. The rookie fifth-round pick out of Alabama continues to work ahead of Brady Russell on offense as Seattle's top fullback, but he's been deployed almost exclusively as a blocker when he's on the field. Ouzts has yet to carry the ball and hasn't been targeted on any of the 29 routes he's ran across 182 total snaps on offense this season.

James played just two snaps -- both on special teams -- in Sunday's 42-38 win over the Bears.

After he was inactive for each of the 49ers' first 14 games, James suited up in Week 16 as the 49ers' No. 3 running back over Isaac Guerendo. The rookie fifth-round pick out of Oregon played just three snaps on offense in the 21-point win over the Colts, and with Sunday's contest proving to be more competitive, James disappeared from the game plan entirely. James could once again get the nod over Guerendo in Saturday's regular-season finale versus the Seahawks, but with the NFC West title on the line, expect Christian McCaffrey (back) and Brian Robinson to handle all of the available snaps at running back.

Homer played all 18 of his snaps on special teams in Sunday's 42-38 loss to the 49ers.

Homer suited up as the Bears' No. 3 running back but, as per usual, he didn't receive any reps on offense behind D'Andre Swift and Kyle Monangai and continued to offer most of his utility on Chicago's coverage units. For the season, Homer has played just six total snaps on offense and has carried once for minus-two yards over his nine appearances.

McCaffrey won't practice Tuesday due to back stiffness, Matt Barrows of The Athletic reports.

Per David Lombardi of SFStandard.com, McCaffrey said the back issue isn't anything serious. McCaffrey dealt with the same injury concern earlier this month but was ultimately active for the 49ers' 37-24 win over the Titans back in Week 15. He hadn't been listed on the injury report in the ensuing two weeks, but the Niners are coming off a back-and-forth fight with the Bears this past Sunday and have a quick turnaround for the battle for the NFC's No. 1 seed this Saturday against the Seahawks. The expectation is that McCaffrey will be ready to play Saturday, but whether he takes a designation into the contest won't be known until the 49ers release their final injury report Thursday.

The Buccaneers signed Williams to the practice squad Tuesday, Greg Auman of Fox Sports reports.

Williams was waived from the Buccaneers' active roster Monday, but he will remain in Tampa Bay as a member of the team's practice squad. He last saw regular-season action in Week 10 against the Patriots and has logged four carries for 11 yards and five kickoff returns for 129 yards across three games.

The Jets signed Blackshear to the practice squad Tuesday, Susanna Weir of the team's official site reports.

Blackshear has not appeared in a regular-season game in 2025 and was on the Steelers' practice squad before being cut in late October. He could be elevated to the Jets' active roster for Sunday's regular-season finale against the Bills if either or both of Breece Hall (knee) and Isaiah Davis (concussion) are unable to play.