The Saints signed Edwards-Helaire to the practice squad Wednesday.

Alvin Kamara came out of this past Sunday's loss to the Commanders with an adductor injury, which is clouding his availability for a Week 16 road matchup with the Packers. If Kamara cedes reps to others Monday night, Kendre Miller likely would get the first chance to handle early-down work, but Jamaal Williams, Jordan Mims, practice-squad member Xazavian Valladay and now Edwards-Helaire would be candidates for work.

Hasty (ankle) was a DNP for Wednesday's practice, Mike Reiss of ESPN.com reports.

Hasty played 10 snaps (two on offense, eight on special teams) during this past Sunday's 30-17 loss to Arizona and finished with 24 kick return yards. However, the fifth-year running back appears to have come out of that contest worse for wear with an ankle injury, which had him sidelined for Wednesday's practice. Hasty's practice participation over the next two days will dictate his chances of playing against Buffalo on Sunday.

Benson (ankle) didn't take part in Wednesday's practice, Josh Weinfuss of ESPN.com reports.

Benson was removed from the second half of this past Sunday's win against the Patriots due to an ankle injury, which so far is keeping him off the practice field to begin Week 16 prep. With Emari Demercado (back) on injured reserve, DeeJay Dallas is the only other running back on the Cardinals' active roster aside from starter James Conner. Meanwhile, Michael Carter and Tony Jones loom as backfield options on the practice squad.

Blackshear (chest) was a full participant in Wednesday's practice.

Blackshear missed Carolina's Week 15 loss to the Cowboys after sustaining a chest injury the game prior, however, Wednesday's full practice session suggests he's already moved past the issue. The Virginia Tech product will likely have a larger offensive role for the remainder of the season, serving as the Panthers' No. 2 running back with Jonathon Brooks (knee) and Miles Sanders (ankle) both on injured reserve.

Mixon was a limited participant at practice Wednesday due to ankle injury.

Mixon, who was also deemed limited Tuesday, suffered a minor ankle injury in this past Sunday's win over the Dolphins, but the running back said Wednesday that he anticipates playing Saturday against the Chiefs, according to Aaron Wilson of KPRC 2 Houston. Thursday's injury report will clarify whether or not Mixon heads into the weekend with an injury designation, but at this stage, he looks like he'll be ready to handle his usual role Saturday as Houston's lead back.

Edwards-Helaire agreed to a contract with the Saints on Wednesday, Nick Underhill of NewOrleans.Football reports.

The report doesn't specify whether Edwards-Helaire will be joining the Saints' active roster or signing with the team's practice squad. Either way, the former Chiefs running back could contribute for the stretch run on a Saints team that could be without lead back Alvin Kamara (groin) for Monday's game against the Packers. Edwards-Helaire didn't appear in a game for the Chiefs during the 2024 season prior to being waived Monday.

McLaughlin (quadricep) has been ruled out for Thursday's game against the Chargers, Susanna Weir of the Broncos' official site reports.

McLaughlin made an early exit from Sunday's win over the Colts and never returned to the game, finishing with 10 touches for 34 yards. The Broncos then listed him as a non-participant Monday and Wednesday, sandwiched around a limited listing Tuesday. McLaughlin has played less than 40 percent of the snaps on offense in every game this season, but he's taken on a larger share of the backfield carries and touches in recent weeks, which mean his absence warrants significant upgrades to the Week 16 projections for fellow Broncos running backs Javonte Williams and Audric Estime.

Pollard (ankle) didn't practice Wednesday, Jim Wyatt of the Titans' official site reports.

Pollard has played through foot and/or ankle injuries for the better part of two months, including last week when he was listed as questionable and then briefly left a 37-27 loss to the Bengals in the first half after aggravating his ankle. He returned to the game and took 10 more carries for 18 yards to finish with a 17-45-1 rushing line, but Tyjae Spears then dominated the playing time and touches in the fourth quarter with Tennessee trailing by multiple scores. Pollard is at some risk of either missing Sunday's game against the Colts or handling a lesser role than what he's been tasked with for most of the season.

Tracy was a limited participant at Wednesday's practice due to an ankle injury, Patricia Traina of SI.com reports.

Tracy dealt with a right low-ankle sprain in August, but the health concern didn't affect his status for Week 1 and beyond. Since he regularly started earning a 60 percent snap share beginning Week 5 at Seattle, he's averaged 16.6 touches for 84.5 yards from scrimmage per game while scoring five rushing touchdowns over the last 10 contests. Tracy's status will be watched as the week continues to get a sense of his availability for Sunday's road matchup with the Falcons.

Las Vegas signed Collier from its practice squad to the active roster on Wednesday.

Collier was added to the Raiders' practice squad back in November, and with Sincere McCormick (ankle) bound for injured reserve, the team saw fit to promote Collier ahead of Week 16. His quickest path to playing time could be on special teams, where he made the majority of his contributions with Baltimore earlier in the season.