Mostert rushed once for six yards and caught his lone target for three yards in Sunday's 23-21 loss to the Texans. He also returned two kickoffs for 53 yards.

Mostert's only carry of the contest didn't come until the start of the fourth quarter, and workhorse running back Ashton Jeanty hogged the offensive spotlight with 25 total touches for 188 yards and two scores. A similarly one-sided backfield split can be expected against the Giants in Week 17.

Judkins will undergo surgery Tuesday in Cleveland to repair a dislocated right ankle and fractured fibula, Mary Kay Cabot of the Cleveland Plain Dealer reports.

Judkins will face a 4-to-5-month recovery timeline following surgery, putting him on track to be available for the start of training camp in late July. In his absence over the final two games of the season, Cleveland will rely on a committee of running backs that includes Dylan Sampson (hand/calf), Raheim Sanders and Trayveon Williams. Judkins wrapped up his rookie campaign with 230 carries for 827 yards (3.6 average) and seven touchdowns to go with 26 catches for 171 yards on 36 targets over 14 games.

Cleveland head coach Kevin Stefanski said Monday that Sampson (hand/calf) is improving by the day, Noah Monroe of the Browns' official site reports.

Sampson sat out the Browns' Week 16 loss to the Bills, but the team has optimism the rookie running back will be back in action this Sunday against the Steelers. With Quinshon Judkins (ankle/fibula) out of action for the remainder of the season, the Browns hope to have a full complement of backs available that includes Sampson, Raheim Sanders and Trayveon Williams. If all are healthy for Week 17, Sampson would likely be in line to serve as the team's lead back.

McCaffrey handled 21 carries for 117 yards and caught six of eight targets for 29 yards and a pair of touchdowns in Monday's 48-27 win over Indianapolis.

McCaffrey and the Colts' Jonathan Taylor headlined a matchup featuring two of the league's top running backs on Monday Night Football. McCaffrey got the better of Taylor (16-46-1) despite facing the stiffer of the two defenses, doubling the latter's yards from scrimmage and scoring output in a winning effort. McCaffrey pushed his rushing total over the 1,000-yard mark for the season while sitting 151 yards shy of doing the same as a receiver with two games left in the regular season. With the 49ers having a potential path to the No. 1 seed in the NFC, fantasy managers can expect the team to lean heavily on McCaffrey against the Bears in Week 17, especially if star TE George Kittle (ankle) is unable to suit up.

Taylor rushed 16 times for 46 yards and a touchdown and brought in all three targets for 33 yards in the Colts' 48-27 loss to the 49ers on Monday night.

Taylor salvaged his fantasy night with a one-yard touchdown run early in the fourth quarter, which narrowed a 34-20 deficit. The star back otherwise was stonewalled on the ground for the majority of the night, although he made some solid contributions as a receiver. Taylor's rushing yardage total was his second lowest of the season, while his average of 2.9 yards per carry was a new low-water mark. He hasn't eclipsed the 100-yard mark on the ground since his memorable 244-yard performance against the Falcons in Berlin in Week 10, and he'll draw another tough matchup at home against the Jaguars in a Week 17 divisional clash Sunday.

The NFL lifted Williams' six-game suspension Monday, Aaron Wilson of KPRC 2 Houston reports.

Williams has served his six-game suspension for violating the NFL's performance-enhancing substances policy. He'll be available for Sunday's game against the Dolphins, though he's unlikely to be part of the Buccaneers' backfield rotation that consists of Bucky Irving, Rachaad White and Sean Tucker. Williams did turn five kickoffs for 129 yards in Week 5 against the Seahawks, and that could be his role for Sunday's road tilt.

Mafah (shoulder) was estimated as limited on Monday's practice report, Nick Harris of the Fort Worth Star-Telegram reports.

Mafah remains on injured reserve but had his 21-day practice window opened last week. The rookie has spent the first 16 weeks of the season on injured reserve after suffering the injury during the preseason.

James is active for Monday night's game against the Colts.

James is getting the nod as San Francisco's RB3 over Isaac Guerendo, who had been active for all 14 games prior to Monday night. James appears poised to make his regular-season NFL debut versus Indianapolis.

Guerendo (coach's decision) is inactive for Monday night's game against the Colts.

Guerendo has appeared in all 14 games this season leading up to Monday night, but rookie Jordan James is getting the nod over him against the Colts as the Niners' RB3 behind Christian McCaffrey and Brian Robinson. All of Guerendo's 173 snaps this season have come on special teams.

Jones (ankle) was listed as limited on Monday's practice estimate, Craig Peters of the Vikings' official site reports.

Jones exited in the first quarter of Sunday's 16-13 win over the Giants with an ankle injury, but he subsequently returned en route to carrying 21 times for 85 yards and catching two of his three targets for eight yards. His listed limitations Monday are likely maintenance-related, and at this stage there's nothing to suggest that Jones will miss Thursday's game against the Lions. Meanwhile, fellow RB Jordan Mason, who didn't return to Sunday's contest after sustaining an ankle injury, was listed as a non-participant Monday.