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Jonathan Taylor RB | IND
Colts' Jonathan Taylor: Strong numbers in lopsided loss
Taylor rushed 19 times for 98 yards and two touchdowns and brought in three of four targets for 23 yards in the Colts' 41-23 loss to the Ravens on Sunday. He also lost a fumble.
Taylor and the Colts' offense as a whole got the new season off to a highly encouraging start, capping off a crisp opening drive with the star running back's one-yard touchdown run. Taylor would go on to add a three-yard scoring rush late in the first half after the Ravens had gone on to rattle off 28 straight points, with Taylor's fumble after a 14-yard reception leading to one of Baltimore's touchdowns. Outside of the turnover, Taylor's overall numbers in a game during which his rushing opportunities were capped late were still useful for fantasy managers, and he'll be slated for another prominent role in a Week 2 road showdown against the Chiefs next Sunday night.
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James Cook III RB | BUF
Bills' James Cook: Held in check by Houston
Cook rushed 13 times for 57 yards and caught three of four targets for 12 yards in Sunday's 36-31 win over the Texans.
Cook didn't find much room against Houston's stout front and took a back seat to Josh Allen, who had two rushing touchdowns and two touchdown passes. Allen's presence didn't stop Cook from rushing for a league-high 1,621 rushing yards during the 2025 regular season, so there should be better days ahead for Buffalo's shifty running back. Cook will have a short turnaround before Buffalo's home opener against the Lions on Thursday.
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Chase Brown RB | CIN
Bengals' Chase Brown: Gets into end zone in win
Brown rushed 16 times for 56 yards and a touchdown and brought in five of six targets for 22 yards in the Bengals' 33-27 win over the Buccaneers on Sunday.
As his final line indicates, Brown unsurprisingly found running room at a premium against the Buccaneers' typically stingy front. Nevertheless, head coach Zac Taylor stuck with the ground attack throughout the afternoon, and Brown, as expected, comfortably outpaced backfield mate Samaje Perine by 11 carries. The versatile back recorded his one touchdown from five yards out with just under six minutes remaining in the second quarter, and he finished tied for the team lead in receptions while also serving as co-runner-up in targets. Brown's busy afternoon should be the norm for him this season, and he'll look to grind out some tough yards again in a Week 2 road showdown against the Texans next Sunday.
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David Montgomery RB | HOU
Texans' David Montgomery: Three total TDs in Texans debut
Montgomery rushed 20 times for 60 yards and two touchdowns while catching all three of his targets for 19 yards and a touchdown in Sunday's 36-31 loss to the Bills.
Montgomery scored Houston's first two touchdowns of the season with a one-yard run in the first quarter followed by an 18-yard run in the second. The offseason trade acquisition from Detroit added a third touchdown on a seven-yard catch as the Texans pulled ahead 28-27 early in the fourth quarter, but Houston's vaunted defense failed to hold that lead. Montgomery's 23 touches in his Texans debut were more than he had in any of his 17 regular-season appearances in 2025 for Detroit, where he had to share the backfield with Jahmyr Gibbs. Woody Marks had 10 touches for 40 yards in a change-of-pace role behind Montgomery, but the latter is clearly Houston's top running back heading into a Week 2 home game against the Bengals.
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Breece Hall RB | NYJ
Jets' Breece Hall: Tops century mark in Week 1 win
Hall rushed 22 times for 102 yards and a touchdown while catching both of his targets for 16 yards in Sunday's 23-10 win over the Titans.
The Jets overpowered the Titans at the line of scrimmage, controlling the clock with the running game while keeping Tennessee to three points through 57 minutes. Hall didn't enjoy many favorable game scripts as the Jets went 3-14 last season, but he capitalized on the heavy workload in the season-opening win while racking up 24 touches to Braelon Allen's 10. Rookie TE Kenyon Sadiq scored a three-yard rushing touchdown in the first quarter as new OC Frank Reich reached deep into his playbook early, but Hall also found the end zone with a four-yard touchdown run in the third quarter. Hall and the Jets will look to build on this strong start in their Week 2 home opener against the Packers.
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Demond Claiborne RB | MIN
Vikings' Demond Claiborne: Won't make NFL debut Week 1
Claiborne (coach's decision) is inactive for Sunday's game against the Packers, Craig Peters of the Vikings' official site reports.
Claiborne, a sixth-round selection of the Vikings in the 2026 NFL Draft, will have to wait until Week 2 against the Bears on Sunday, Sept. 20, to make his regular-season debut. With Claiborne inactive for Week 1, DeeJay Dallas will serve as the Vikings' RB3 behind Aaron Jones and Jordan Mason.
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Jeremiyah Love RB | ARI
Cardinals' Jeremiyah Love: Set for NFL debut
Love (ankle) is listed as active Sunday at the Chargers.
Love thus has put the high-ankle sprain that he sustained in preseason Week 1 behind him, but considering he wasn't able to practice in more than a limited capacity this week, there's a decent chance that he won't be operating on all cylinders in his NFL debut. The third overall pick in this year's draft also will have to contend with Tyler Allgeier for work out of the Cardinals backfield, so Love may take some time to fulfill his draft status.
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Dylan Sampson RB | CLE
Browns' Dylan Sampson: Won't return to Sunday's contest
Sampson (knee) has been downgraded to out for Sunday's game against the Jaguars.
Sampson was initially deemed questionable to return after injuring his knee in the first quarter, but after making a visit to the medical tent on the sideline followed by two trips to the locker room, the Browns determined that his day is over, per Daniel Oyefusi of ESPN.com. His absence leaves Cleveland with Raheim Sanders as its lone backup behind starter Quinshon Judkins for the remainder of the game. Sampson didn't receive any touches on offense but gained 64 yards on two kickoff returns prior to his departure.
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Dylan Sampson RB | CLE
Browns' Dylan Sampson: Hurts knee, iffy to return
Sampson sustained a knee injury in the first quarter of Sunday's game against the Jaguars and is considered questionable to return, Mary Kay Cabot of The Cleveland Plain Dealer reports.
Sampson didn't receive any touches on offense but returned two kickoffs for 64 yards before exiting the contest. The second-year running back headed to the locker room and will be evaluated further before the Browns decide whether he'll be able to return to the game.
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Nicholas Singleton RB | TEN
Titans' Nicholas Singleton: Inactive for Week 1
Singleton (coach's decision) is inactive for Sunday's game against the Jets.
The rookie fifth-rounder will be a healthy scratch Week 1 while the Titans role with three active running backs in Tony Pollard, Tyjae Spears and Julius Chestnut. Singleton's next opportunity to make his NFL regular-season debut is Week 2 against the Eagles on Sunday, Sept. 20, though he's unlikely to suit up for that contest unless one of Pollard, Spears or Chestnut is sidelined.