Coach Kyle Shanahan said Pearsall (knee) won't take part in practice Wednesday, Cam Inman of The San Jose Mercury News reports.

Pearsall has been tending to a minor PCL injury in his right knee since making an early exit from the 49ers' Week 4 loss to the Jaguars. He's been a non-participant at practice since then, and Shanahan added that the 49ers are "not counting on" Pearsall being available for Sunday's game at Tampa Bay, according to David Lombardi of SFStandard.com. Ultimately, Pearsall's fate for Week 6 action may become known as soon as the team posts Friday's practice report.

Pierce (concussion) practiced fully Wednesday.

Pierce, who has missed two straight contests, practiced fully last Wednesday and Thursday before downgrading to a 'DNP' listing Friday, so his return to a full session this Wednesday's bodes well for his chances of returning to action Sunday against the Cardinals. In that scenario, Pierce would be in line to reclaim his role alongside fellow WRs Michael Pittman and Josh Downs, which thus far has yielded him a 9/171/0 receiving receiving line (on 13 targets) through three contests.

St. Brown missed practice Wednesday due to a wrist injury.

Per Nolan Bianchi of The Detroit News, St. Brown wasn't taking part during the media-access portion of Wednesday's session, and now the reason for his lack of work has become known. St. Brown will have two more chances to mix into drills this week ahead of Sunday's road showdown with the Chiefs. Through five games this season, he's reached 100 receiving yards two times while scoring six touchdowns.

Austin was a non-participant in Wednesday's practice, Brooke Pryor of ESPN.com reports.

Steelers coach Mike Tomlin said Austin is a player who could ramp up his practice activity "toward the latter part of the week," Teresa Varley of the team's official site reports, but it's nonetheless a bad sign to see the wideout absent from practice despite having had a bye to get right. Austin will presumably need to return to practice as at least a limited participant Thursday and/or Friday in order to have a chance at suiting up Sunday versus the Browns.

Coker (quadriceps) was a full practice participant Wednesday.

It was his first practice since Aug. 28, but the full participation suggests Coker has a chance to play this Sunday against the Cowboys. Carolina could certainly use his help, as the team is currently getting minimal production from any of the wide receivers behind No. 1 target Tetairoa McMillan. Coker split time between the slot and perimeter as a UDFA-turned-starter in 2024, presumably giving him a good feel for Dave Canales' offensive system as he prepares for a late start to his second NFL season. Coker soon figures to take playing time away from Xavier Legette and/or Hunter Renfrow.

Commanders coach Dan Quinn said Wednesday that Brown (groin/knee) will participate in practice, Tashan Reed of The Washington Post reports.

Brown will resume practicing Wednesday but Terry McLaurin (quadriceps) will not, per Quinn. A pair of injuries has kept Brown sidelined for three consecutive games, but he appears to be trending in the right direction for Monday's home matchup against the Bears. When active for Washington's first two games of the season, Brown handled just under 50 percent of offensive snaps and tallied a combined three catches for 36 yards on seven targets.

Commanders coach Dan Quinn said McLaurin (quadriceps) won't practice Wednesday, Tashan Reed of The Washington Post reports.

Quinn expressed optimism earlier this week about McLaurin's chances of suiting up Week 6 against the Bears on Monday, but the veteran wideout isn't yet ready to return to the practice field. McLaurin has missed two straight contests without practicing at all in that span. It's possible the team is simply taking a cautious approach to McLaurin's recovery, and that he'll have better odds of handling on-field work as Week 6 preparation progresses. On a positive note for Washington, Quinn said Noah Brown (groin/knee) will return to practice Wednesday.

Slayton (hamstring) is ruled out for Thursday's game against the Eagles, Dan Salomone of the Giants' official site reports.

Slayton will miss Thursday's divisional matchup due to a hamstring injury sustained during Sunday's loss to the Saints. His next opportunity to take the field will come Sunday, Oct. 19 on the road against Denver in Week 7. With Slayton unavailable Thursday, Lil'Jordan Humphrey is expected to be elevated from the practice squad.

The Panthers are designating Coker (quadriceps) to return to practice from IR on Wednesday, Darin Gantt of the team's official site reports.

The transaction opens a 21-day window wherein Coker can be evaluated at practice without counting against the 53-man roster. Carolina can activate him at any point during that time, including getting him back on the field as early as Sunday versus the Cowboys. He's recovering from a quad injury suffered Aug. 28.

Pierce (concussion) is in line to practice Wednesday, James Boyd of The Athletic reports.

Pierce has missed the last two games, but his looming ability to practice Wednesday is a positive step ahead of Sunday's game against the Cardinals. The wideout practiced fully last Wednesday and Thursday before downgrading to a 'DNP' listing Friday, so his level of participation as the Colts begin their Week 6 preparation will be notable.