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Brandon Aiyuk WR | SF
49ers' Brandon Aiyuk: Future with franchise uncertain
Aiyuk (knee) is considered unlikely to play for the 49ers again after the team voided guarantees in his contract for 2026, Dianna Russini and Michael Silver of The Athletic report.
The 49ers reportedly voided the guarantees in response to Aiyuk missing meetings and declining to participate in other team activities the past couple months while he finished up his rehab from the ACL and MCL tears he sustained last October. Head coach Kyle Shanahan said Nov. 10 that he was "pretty confident" Aiyuk would play at some point this season, but the wideout seemingly doesn't want to play for San Francisco at all. With the trade deadline having come and gone, Aiyuk may have to miss the entire season even if he's physically ready to play soon. He's in the first season of a four-year, $130 million extension, but the report suggests Aiyuk will angle for his release this offseason, rather than filing a grievance or agreeing to play on a non-guaranteed salary. He'll turn 28 in March and shouldn't lack for free-agent suitors if it comes to that.
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Quay Walker LB | LV
Packers' Quay Walker: Doubtful for Sunday
Walker (neck) did not participate in practice Friday and is doubtful for Week 12 action, Rob Demovsky of ESPN.com reports.
Walker was unable to participate in practice this week after suffering a neck injury Sunday against the Giants. With his status for Week 12 in doubt, Isaiah McDuffie and Ty'Ron Hopper could both see more than their usual amount of defensive snaps.
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Micah Parsons LB | GB
Packers' Micah Parsons: Set to play Sunday
Parsons (pectoral) has no injury designation ahead of Sunday's matchup against the Vikings, Rob Demovsky of ESPN.com reports.
Parsons has been dealing with a pectoral injury for the past few weeks but was a full participant in practice Friday for the first time since Week 10 this season. The 26-year-old will make his 11th start of the season Sunday versus Minnesota.
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Keisean Nixon DB | GB
Packers' Keisean Nixon: Ready to go for Sunday
Nixon (illness) was a full participant in practice Friday, Rob Demovsky of ESPN.com reports.
Nixon appeared on the injury report with an illness and was limited in practice both Wednesday and Thursday. However, the 28-year-old was back to full participation Friday and is in line to be ready for Sunday's matchup against the Vikings.
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Bo Melton WR | GB
Packers' Bo Melton: Clear for Sunday
Melton (shoulder) was a full participant in practice Friday and doesn't carry a Week 12 injury designation, Rob Demovsky of ESPN.comreports.
Melton was added to the injury report Thursday after logging a limited practice, but he is ready to go for Sunday's matchup against the Vikings. The 26-year-old should be expected to participate on special teams and at cornerback, as he has throughout the season.
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Nate Hobbs CB | SF
Packers' Nate Hobbs: Ruled out Sunday
The Packers have ruled out Hobbs (knee) for Sunday's game against the Vikings, Rob Demovsky of ESPN.comreports.
Hobbs missed the last two games with a knee sprain and was unable to practice this week. Week 13 against Detroit will be the 26-year-old's next opportunity to play. Carrington Valentine and Keisean Nixon will continue to play in his place.
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Chimere Dike WR | TEN
Titans' Chimere Dike: Could lead depleted Titans WR room
Dike (chest) doesn't have an injury designation for Sunday's game against the Seahawks, while Elic Ayomanor (hamstring) has been ruled out, Jim Wyatt of the Titans' official site reports.
The Titans are without Calvin Ridley (fibula) for the rest of the season, and Ayomanor will join him on the sidelines Sunday. Their absences could open the door for Dike and Van Jefferson to see more targets, with Mason Kinsey and James Proche also vying for increased opportunities. Dike posted 163 receiving yards and a touchdown in a two-game span Weeks 7 and 8, but he hasn't exceeded 17 receiving yards in any other game.
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Edgerrin Cooper LB | GB
Packers' Edgerrin Cooper: Set to play Sunday
Cooper (foot) doesn't carry an injury designation for Sunday's game against the Vikings, Rob Demovsky of ESPN.com reports.
Cooper was limited in practice both Wednesday and Thursday with a lingering foot injury. However, the 24-year-old is ready to go for Sunday's matchup against Minnesota after logging a full session Friday. The second-year pro has started every game this season while managing the injury, accounting for 74 tackles, including 0.5 sacks, and two forced fumbles.
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Jayden Reed WR | GB
Packers' Jayden Reed: Not returning Sunday
Reed (foot/shoulder) has been ruled out for Sunday's game versus the Vikings.
The Packers designated Reed for return from injured reserve Friday, and he proceeded to be limited at the ensuing practice. His last appearance occurred Week 2 when he broke his collarbone, which gave him a chance to not only get surgery to address that injury but also the foot issue that he dealt with in training camp. Reed told Mike Spofford of the team's official site after Friday's session that "it felt great just to go back out there with the guys and be able to fly around again. Everything feels great right now. I'm just following the protocol and just waiting for my number to be called. I don't know when I'll be back." Reed's next chance for game action is Thanksgiving Day at Detroit.
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Curtis Samuel WR | BUF
Bills' Curtis Samuel: Progressing in recovery
Samuel (elbow/neck) is improving in his recovery, head coach Sean McDermott said Friday, Maddy Glab of the Bills' official site reports.
Samuel sat out Thursday's loss to the Texans but he could be back for Buffalo's next game, Nov. 30 at Pittsburgh. Keon Coleman has been held out of the Bills' last two games as a coach's decision, so more targets could be available for Samuel if he's healthy enough to rejoin a Bills receiving corps that's searching for consistent production behind Khalil Shakir.