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Tommy DeVito QB | NE
Patriots' Tommy DeVito: Emergency QB vs. New Orleans
DeVito (coach's decision) is inactive for Sunday's game against the Saints but will serve as the emergency third quarterback.
DeVito will remain as the Patriots' emergency third quarterback, meaning he will only see the field in New Orleans if Drake Maye and Joshua Dobbs were to depart due to injury, illness or ejection.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Ready to go for Week 6
Kamara (ankle) is active for Sunday's game against the Patriots.
A limited participant in practice throughout the week due to the ankle injury, Kamara took a questionable tag into the weekend but never seemed at major risk of missing Sunday's contest. Now that he's confirmed as available for the Week 6 contest, Kamara should continue in his usual role as the Saints' lead option out of the backfield. Though Kamara's name has popped up in trade rumors as the 1-4 Saints navigate what looks to be a rebuilding season, Ian Rapoport of NFL Network reported Saturday that the 30-year-old back told general manager Mickey Loomis that he would like to remain with the franchise for the duration of his career. The Saints are expected to honor Kamara's request and hold on to him ahead of the Nov. 4 trade deadline, even though multiple contending teams would likely be in the market for his services.
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Jacoby Brissett QB | ARI
Cardinals' Jacoby Brissett: Getting start in place of Murray
Brissett is starting Sunday's game at Indianapolis with Kyler Murray (foot) inactive, Darren Urban of the Cardinals' official site reports.
Brissett has been preparing to lead the Cardinals offense Week 6 due to Murray's foot injury, which was described as a mid-foot sprain by Ian Rapoport of NFL Network on Saturday evening that may require more than one week on the sideline. With Murray confirmed to be out this Sunday, Brissett will earn a start for the fifth different team in his 10-year career. He went 1-4 last season as a member of the Patriots, when he completed 79 of 135 passes (58.5 percent) for 696 yards, two touchdowns and one interception, had 12 carries for 51 yards and no TDs and fumbled three times (one lost) in those nods.
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Kyler Murray QB | MIN
Cardinals' Kyler Murray: Officially inactive Sunday
Murray (foot) is listed as inactive Sunday at Indianapolis.
Murray made a brief exit due to a foot injury Week 5 against the Titans and then didn't practice Wednesday or Thursday before returning in a limited capacity Friday and earning a questionable designation for Week 6. Both Adam Schefter of ESPN and Ian Rapoport of NFL Network reported Saturday evening that Murray wasn't expected to play Sunday, and Rapoport even noted the quarterback is dealing with a mid-foot sprain that may require more than one week on the sideline. For as long as Murray is unavailable, Jacoby Brissett will direct the Cardinals offense.
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Michael Carter RB | TEN
Cardinals' Michael Carter: Expected to lose touches to Knight
Bam Knight is expected to take on a bigger workload out of the Cardinals backfield alongside Michael Carter and Emari Demercado in Sunday's game against the Colts, Adam Schefter of ESPN reports.
Per Schefter, in a game that QB Jacoby Brissett is expected to start in place of Kyler Murray (foot), Knight -- who logged five touches in last week's 22-21 loss to the Titans -- is expected to see an expanded role, with Schefter suggesting that Knight is on track to work ahead of Carter, who had 23 touches versus Tennessee. With that context in mind, and with Demercado (three carries Week 5) also in the mix, Carter profiles as a hit-or-miss fantasy lineup option Sunday.
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Zonovan Knight RB | ARI
Cardinals' Bam Knight: In line for bigger role
Knight is expected to take on a bigger workload out of the Cardinals backfield Sunday at Indianapolis, Adam Schefter of ESPN reports.
In the absences of James Conner (foot) and Trey Benson (knee) last Sunday against the Titans, Knight was third in the RB rotation behind Michael Carter and Emari Demercado, but Schefter specifically noted that Knight is in line to work in front of Carter in Week 6. Carter recorded 23 touches on a 73 percent snap share Week 5, while Demercado (three touches, 28 percent) and Knight (five touches, 16 percent) were well behind him. If Knight supplants Carter at the top of the depth chart, the former would be slated for significant increases in both touches and snaps.
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Milton Williams DT | NE
Patriots' Milton Williams: Under the weather
Williams is questionable to play against the Saints on Sunday due to an illness.
Williams was cleared to play after working through an ankle injury all week, but he's now dealing with an illness that puts him in jeopardy of missing Sunday's game. Cory Durden and rookie fourth-rounder Joshua Farmer would be in line to see more snaps at defensive end if Williams is not cleared to play.
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Cam Jones LB | KC
Jets' Cam Jones: Exits with hip injury
Jones is questionable to return to Sunday's game against Denver due to a hip injury.
Jones went to the sidelines to be evaluated for his hip injury to determine whether he can return to Sunday's game. The third-year linebacker has been primarily deployed on special teams this season.
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Hassan Haskins RB | NE
Chargers' Hassan Haskins: Candidate to lead backfield Sunday
Haskins is expected to lead the Chargers backfield Sunday against the Dolphins, with Kimani Vidal also slated to mix in, Mike Garafolo of NFL Network reports.
That said, offensive coordinator Greg Roman told Kris Rhim of ESPN.com on Thursday that the Chargers weren't planning on leaning on a lead back in Week 6 with Omarion Hampton (ankle) landing on injured reserve. Instead, Roman noted that Haskins and Vidal are both "gonna be big factors in the game, how it's gonna unfold from snap count standpoint...can go a bunch of different ways in that regard." Even if Haskins draws the start, both backs should contribute versus Miami as the team adjusts to being without Hampton for at least four weeks, with Garafolo suggesting that the running back's absence could extend beyond that timeframe. Meanwhile, Garafolo indicates that it's also possible that the Chargers add backfield depth ahead of the Nov. 4 trade deadline. Either way, Haskins and Vidal both represent lineup options for fantasy managers who had been leaning on Hampton or are otherwise looking for backfield help this week.
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Will McDonald IV DE | NYJ
Jets' Will McDonald: Being evaluated for concussion
McDonald is being evaluated for a possible concussion and is questionable to return to Sunday's game against the Broncos.
McDonald sustained a head injury during the first half of Sunday's game, and he is being evaluated by medical staff to determine whether he can return. Micheal Clemons and Braiden McGregor will see more snaps at defensive end for as long as McDonald is out of the game.