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Van Jefferson WR | WAS
Titans' Van Jefferson: Questionable to face LV
Jefferson (ankle) was a full participant in Friday's practice but is listed as questionable for Sunday's game against the Raiders, Jim Wyatt of the Titans' official site reports.
Jefferson appeared to pick up an ankle injury during the Titans' Week 5 win over the Cardinals. He steadily upgraded his practice participation after sitting out of Wednesday's session, but his official status for Sunday's contest may not be known until the Titans announce their list of inactive players approximately 90 minutes prior to the 4:05 p.m. ET kickoff. With Bryce Oliver (knee) already ruled out, the Titans could elevate Mason Kinsey, James Proche or undrafted rookie Xavier Restrepo from the practice squad to the active roster if Jefferson is unable to play.
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Avonte Maddox FS | DET
Lions' Avonte Maddox: Dealing with hamstring injury
Maddox is listed as questionable for Sunday's game against the Chiefs due to a hamstring injury, Justin Rogers of DetroitFootball.net reports.
Maddox popped up on Thursday's practice report as a limited participant due to a hamstring injury, which was severe enough for him to not practice Friday. That's a trend in the wrong direction for the veteran corner, but his official status may not be known until approximately 90 minutes prior to Sunday's 8:20 p.m. ET kickoff. Maddox has provided rotational help in the secondary while also contributing on special teams, but his absence would hurt a Lions secondary that is already without Terrion Arnold (shoulder) and could be missing Brian Branch (ankle) and Kerby Joseph (knee).
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Kerby Joseph SAF | DET
Lions' Kerby Joseph: Iffy to play against Kansas City
Joseph (knee) is listed as questionable for Sunday's game against the Chiefs, Justin Rogers of DetroitFootball.net reports.
Joseph and fellow starting safety Brian Branch (ankle) are both questionable for Sunday's road tilt, which opens the door for special-teams contributors Thomas Harper and Loren Strickland to log defensive snaps. Joseph has managed to play through a lingering knee issue from mid-September, though he wasn't able to participate in any capacity this week.
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Jauan Jennings WR | MIN
49ers' Jauan Jennings: Listed as questionable
Jennings (ankle/rib) is listed as questionable for Sunday's game at Tampa Bay, Matt Maiocco of NBC Sports Bay Area reports.
After missing Week 5, Jennings returned to practice Thursday and Friday as a limited participant, giving him a chance to suit up Week 6. Teammates Brock Purdy (toe) and Ricky Pearsall (knee) have been ruled out, while QB Mac Jones (oblique/knee) joins Jennings with a questionable designation ahead of Sunday's 4:25 p.m. ET kickoff. Kendrick Bourne, Demarcus Robinson and Marquez Valdes-Scantling are the likely beneficiaries if Jennings doesn't end up playing or is limited.
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Mac Jones QB | SF
49ers' Mac Jones: Listed as questionable
Jones (knee/oblique) is listed as questionable for Sunday's game at Tampa Bay, Matt Maiocco of NBC Sports Bay Area reports.
With Brock Purdy (toe) ruled out again, Jones is gearing up to play through a pair of injuries. Jones was already fighting through a minor PCL sprain before injuring his oblique during last Thursday's win over the Rams. He was a limited practice participant all of this week, with reports suggesting he did far more throwing Friday after not doing much in the previous two practices. Fantasy managers will still want to keep an eye on the situation ahead of Sunday's 4:25 p.m. ET kickoff, with both Jones and WR Jauan Jennings (ankle) listed as questionable.
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Brian Branch CB | DET
Lions' Brian Branch: Questionable for Week 6
Branch (ankle) did not practice Friday and is listed as questionable for Sunday's game against the Chiefs, Justin Rogers of DetroitFootball.net reports.
Branch sustained an ankle injury during the Lions' Week 5 win over the Bengals. He opened the week with back-to-back limited practices before sitting out Friday's session, and his official status may not be known until the Lions announce their list of inactive players approximately 90 minutes before Sunday's 8:20 p.m. ET kickoff. The Lions' secondary is dealing with multiple injuries, so Branch's absence may lead to Thomas Harper and Loren Strickland -- both of whom have been restricted to special-teams work this season -- seeing the field on defense.
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Sione Vaki RB | DET
Lions' Sione Vaki: Won't play against Kansas City
Vaki (groin) has been ruled out for Sunday's game against the Chiefs, Justin Rogers of DetroitFootball.net reports.
Vaki has not been able to practice since suffering a groin injury in Week 3 against the Ravens. He'll miss a third consecutive game due to the injury, and the 2024 fourth-rounder's next opportunity to play is Week 7 against Tampa Bay on Monday, Oct. 20. Craig Reynolds and Jacob Saylors will continue to serve as the Lions' depth backfield options behind Jahmyr Gibbs and David Montgomery.
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Ricky Pearsall WR | SF
49ers' Ricky Pearsall: Ruled out for Week 6
Pearsall (knee) has been ruled out for Sunday's game at Tampa Bay, David Lombardi of SFStandard.com reports.
Pearsall hasn't practiced since Week 4, when he played through a PCL injury but wasn't able to finish out a loss to the Jaguars. Fellow 49ers wideout Jauan Jennings (ankle) also missed Week 5 but could return this Sunday to face the Buccaneers (he's listed as questionable after practicing Thursday and Friday). Either way, Kendrick Bourne figures to get a lot of playing time again, with Demarcus Robinson and Marquez Valdes-Scantling also in the mix for routes.
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Brock Purdy QB | SF
49ers' Brock Purdy: Ruled out for Sunday
Purdy (toe) has been ruled out for Sunday's game at Tampa Bay, David Lombardi of SFStandard.com reports.
Purdy didn't practice this week, but there was progress reported in the form of increased activity with his side work, per Matt Barrows of The Athletic. Fellow 49ers QB Mac Jones (knee/oblique) is listed as questionable, but he'll likely get the start after practicing Thursday and Friday.
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Zach Cunningham ILB | DET
Lions' Zach Cunningham: Ruled out Week 6
Cunningham (hamstring) has been ruled out for Sunday's game against Kansas City, Justin Rogers of DetroitFootball.net reports.
Cunningham will miss a third consecutive game due to a hamstring injury he sustained during practice leading up to the Lions' Week 4 clash against the Browns. He wasn't able to practice this past week, so he'll aim to return to the field in at least a limited capacity ahead of the Lions' Week 7 home tilt against the Buccaneers on Monday, Oct. 20.