Hairston (ankle) tallied 18 total tackles (14 solo) and five passes defensed, including two interceptions, over 11 regular-season games in 2025.

Hairston, a 2025 first-round pick from Kentucky, missed eight games (including playoffs) during his rookie campaign due to knee, ankle and head injuries. Despite this, the 22-year-old was productive when healthy, tying for second on the team in interceptions while ranking third in passes defensed. Additionally, Hairston tied for the third-most interceptions among rookie defenders. He's expected to start as one of Buffalo's top boundary corners ahead of the 2026 season.

Jones recorded 22 total tackles (11 solo), including 3.0 sacks, two passes defensed, including one interception, and one forced fumble across 12 regular-season games in 2025.

The 34-year-old from Penn State was the Bills' most productive interior pass rusher this season, tallying his highest sack total since his 2017 campaign with the Titans. Additionally, Jones nabbed the first interception of his career in the Week 16 win over the Browns. Set to become an unrestricted free agent this offseason, the veteran will likely find work elsewhere ahead of the 2026 season following the emergence of 2025 fourth-round pick Deone Walker, who operated as the Bills' top interior defensive lineman for most of this season.

Epenesa tallied 32 total tackles (17 solo), including 2.5 sacks, and four passes defensed, including two interceptions, over 16 regular-season games in 2025.

The Iowa product saw declines in several statistical categories compared to last season, recording fewer total tackles (39 to 32), sacks (6.0 to 2.5) and forced fumbles (two to zero) while playing significantly less defensive snaps (583 to 434). Despite the reduced workload, he remained an effective rotational edge defender and tied his career high in interceptions. Set to hit unrestricted free agency this offseason, Epenesa will likely explore other opportunities after his role dimished in 2025. He could draw interest from teams in need of a starting-caliber edge rusher ahead of the 2026 season.

Bosa recorded 29 total tackles (17 solo), including 5.0 sacks, five forced fumbles and two passes defensed across 15 regular-season games in 2025.

The 30-year-old defensive end from Ohio State was one of the Bills' best defenders during his first season in Buffalo, leading the team with nine tackles for loss while ranking second in sacks. Bosa also paced the NFL with a whopping five forced fumbles, including four over the first four games of the regular season. Having signed a one-year deal with the Bills last offseason, he's now set to hit unrestricted free agency. Expect Bosa to draw interest from teams seeking edge-rush help ahead of the 2026 campaign.

Walker logged 39 total tackles (17 solo), including 1.0 sacks, and four passes defensed across 17 regular-season games in 2025.

The 2025 fourth-round pick from Kentucky was thrust into action immediately, starting 16 regular-season contests during his rookie campaign. Walker was the Bills' most productive interior defensive lineman, finishing second on the team in tackles for loss (eight) and tying for fourth in passes defensed. The 21-year-old showed up when it mattered most during Buffalo's two playoff games, recording six total tackles and two passes defensed, including an interception of Bo Nix during the divisional-round loss. Walker is expected to remain an integral portion of the Bills' defensive front for years to come.

Lewis recorded 43 total tackles (33 solo), four passes defensed and two forced fumbles across 17 regular-season games in 2025.

After starting six games and playing 569 defensive snaps during the Bills' 2024 campaign, Lewis started just four contests and logged 370 defensive snaps this regular season. Despite this, the Buffalo product remained a key contributor, tying for the fourth-most passes defensed while playing 222 special-teams snaps. Set to hit unrestricted free agency this offseason, Lewis will likely draw interest from teams in need of secondary depth ahead of the 2026 season.

Rousseau recorded 46 total tackles (24 solo), including 7.0 sacks, two passes defensed and one forced fumble over 16 regular-season contests in 2025.

The 2021 first-round pick from Miami has emerged as Buffalo's best pass rusher, leading the team in sacks each of the past two seasons. Since entering the league, Rousseau has recorded 7.0-or-more sacks in three of his five campaigns, proving to be one of the league's most consistent pass rushers. Additionally, he wreaked havoc during Buffalo's two playoff games, recording eight total tackles, including 1.0 sacks, and two passes defensed. Under contract through the 2029 season, Rousseau is expected to remain the Bills' top edge rusher in 2026.

Thompson tallied 56 total tackles (33 solo), including 1.0 sacks, two passes defensed and one forced fumble over 12 regular-season contests in 2025.

Thompson played just six regular-season games during his final two seasons in Carolina but stayed relatively healthy in his first year with the Bills. He started six games in 2025, recording 37 total tackles, including 1.0 sacks, one pass defensed and one forced fumble during those contests. Additionally, the 31-year-old made a significant impact during the Bills' two playoff games, tallying 13 total tackles and an interception. Set to become an unrestricted free agent this offseason, Thompson will likely find work with a team in need of inside linebacker depth ahead of 2026.

Williams (neck) recorded 63 total tackles (29 solo) and two passes defensed over 16 regular-season appearances in 2025.

Williams was one of the Bills' best defenders in 2024, recording 117 total tackles across 618 defensive snaps. However, he played a smaller defensive role this season, logging just 63 stops over 431 defensive snaps in the regular season. Despite this, the Tulane product remained a key part of Buffalo's defense, as he tallied the fifth-most stops on the team and was an important special-teams contributor (258 snaps). Still on his rookie contract through the 2026 season, Williams, who left the Bills' divisional-round loss to the Broncos with a neck injury, could compete for a starting inside linebacker position this summer.

Bernard (calf) tallied 65 total tackles (44 solo) and three passes defensed, including one interception, over 12 regular-season contests in 2025.

Bernard has seen vast declines across several statistical categories over the last two seasons, recording fewer total tackles (143 to 65), sacks (6.5 to zero), passes defensed (five to three) and interceptions (three to one) compared to his 2023 campaign. However, his 2025 season was cut short by injuries, as he missed five regular-season contests and both of the Bills' playoff games. Bernard was one of Buffalo's best tacklers when healthy, recording the fourth-most stops on the team. Under contract through 2029, the Baylor product is expected to remain one of the Bills' top inside linebackers in 2026.