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Baker Mayfield QB | TB
Buccaneers' Baker Mayfield: Guts out biceps injury in loss
Mayfield completed 22 of 40 passes for 289 yards with two touchdowns and one interception while adding two rushes for 13 yards in the Buccaneers' 31-25 loss to the Eagles on Sunday. He also fumbled once but was able to recover it.
Mayfield got limited throwing work in practice this week due to a biceps issue, but he still mustered his best passing yardage total of 2025, thanks in large part to 77- and 72-yard touchdown passes to Emeka Egbuka and Bucky Irving, respectively. Considering he was playing without Mike Evans (hamstring) and that Chris Godwin was making his season debut, Mayfield's numbers have to be considered encouraging. He'll aim to get the Bucs right back into the win column during a tough Week 5 road matchup against the Seahawks next Sunday afternoon.
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Elijah Mitchell RB | PHI
Chiefs' Elijah Mitchell: Healthy scratch for Week 4
Mitchell (coach's decision) is inactive for Sunday's game against the Ravens, Matt McMullen of the Chiefs' official site reports.
Mitchell will be a healthy scratch for a fourth consecutive game, and his next chance to make his 2025 regular-season debut comes Week 5 against the Jaguars on Monday, Oct. 6. Isiah Pacheco, Kareem Hunt and rookie seventh-rounder Brashard Smith will be Kansas City's three active running backs for Sunday's contest.
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Tyler Goodson RB | DAL
Colts' Tyler Goodson: Exits game due to groin injury
Goodson is questionable to return to Sunday's game against the Rams due to a groin injury, James Boyd of The Athletic reports.
Goodson will continue to be evaluated by medical staff to determine whether he can return to Sunday's contest. DJ Giddens will be the lone backup running back behind Jonathan Taylor if Goodson is not cleared to return.
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Javontae Jean-Baptiste LB | WAS
Commanders' Javontae Jean-Baptiste: May have torn pectoral
Jean-Baptiste will undergo an MRI on a pectoral injury that he suffered during the Commanders' 34-27 loss to the Falcons on Sunday, Nicki Jhabvala of The Washington Post reports.
Per Jhabvala, the Commanders fear that Jean-Baptiste tore his pec during Sunday's loss, which would likely necessitate a lengthy stint on injured reserve. The Commanders received much-needed depth at defensive end by signing Preston Smith (coach's decision) earlier in September, and the veteran could be active for Week 5 against the Chargers on Sunday, Oct. 5 if Jean-Baptiste is sidelined. Jalyn Holmes would also be in line for a significant increase in defensive snaps.
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Travon Walker DE | JAC
Jaguars' Travon Walker: Won't return vs. San Francisco
Walker (wrist) has been ruled out for the rest of Sunday's game against the 49ers, Jennifer Lee Chan of NBC Sports Bay Area reports.
Walker sustained a wrist injury in the first half, and the issue is severe enough for him to be sidelined for the rest of Sunday's contest. Dawuane Smoot and Emmanuel Ogbah will see more snaps at defensive end opposite Josh Hines-Allen in Walker's absence.
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Eric Murray S | JAC
Jaguars' Eric Murray: Exits game with neck injury
Murray is questionable to return to Sunday's game against the 49ers due to a neck injury.
Murray appeared to suffer the injury in the second quarter, when he collided with teammate Travon Walker (wrist). Rayuan Lane and Antonio Johnson are in line to see more snaps at safety alongside Andrew Wingard for as long as Murray is out of the game.
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Kene Nwangwu RB | NYJ
Jets' Kene Nwangwu: Won't play vs. Miami
Nwangwu (hamstring) has been downgraded from doubtful to out for Monday's game against the Dolphins.
Nwangwu was a long shot to play in Monday's contest after drawing the doubtful tag, and he will indeed miss a third consecutive game due to a hamstring injury that he sustained in Week 1 against the Steelers. Isaiah Davis will continue to operate as the Jets' top return option on kickoffs in Nwangwu's absence.
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Roquan Smith ILB | BAL
Ravens' Roquan Smith: Exits with hamstring injury
Smith is questionable to return to Sunday's game against the Chiefs due to a hamstring injury.
Smith sustained the injury in the second quarter, and he has been taken to the locker room to evaluate the issue and determine whether he can return. Trenton Simpson and Jay Higgins are candidates to see increased work at inside linebacker for as long as Smith is out of the contest.
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Tetairoa McMillan WR | CAR
Panthers' Tetairoa McMillan: Paces pass catchers in loss
McMillan secured four of eight targets for 62 yards in the Panthers' 42-13 loss to the Patriots on Sunday.
McMillan had been listed as questionable coming into the afternoon due to a calf issue, but the rookie first-round pick kept up his strong play while recording a team-high receiving yardage total. He also tied with Tommy Tremble for the team lead in targets, and given the disastrous team outcome for Carolina, the talented wideout's numbers were respectable. The Arizona product has risen above the Panthers' offensive struggles overall to eclipse the 60-yard mark in three of his first four NFL games, and he'll look to capitalize on a favorable matchup against the shaky Dolphins defense in a Week 5 home matchup next Sunday afternoon.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Logs moderate outing Week 4
Kamara tallied 15 rushes for 70 yards and gathered in four of five targets for two yards during Sunday's 31-19 loss against the Bills.
Kamara had his second-most productive rushing output of the season and averaged over 4.2 yards per carry for the second time this year. The 30-year-old had been shouldering the bulk of the rushing workload with 50 of the team's 79 carries over the first three games, but RB2 Kendre Miller closed the gap with a season-high 11 rushing attempts for 65 yards Sunday. This may have been part of the Saints' offensive gameplan, as the team logged more rushing attempts (34) than passing attempts (28) for the first time this season. Kamara will look to record his first 100-yard rushing performance of the season next week, facing a Giants defense that's allowed a league-worst 6.1 yards per carry through four weeks.