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Mac Jones QB | SF
49ers' Mac Jones: Limited Wednesday
Coach Kyle Shanahan said Jones (knee) will be a limited practice participant Wednesday, Matt Barrows of The Athletic reports.
Both Jones and No. 1 QB Brock Purdy (shoulder/toe) will operate with a cap on their reps to begin Week 4 prep, and the duo along with practice-squad member Adrian Martinez will handle first-team reps. Jones himself has started the last two games in place of Purdy, completing 53 of 80 passes (66 percent) for 563 yards, four touchdowns and one interception, turning seven carries into five yards and fumbling twice (one lost). If Purdy needs another week to get to 100 percent, Jones likely would get the start Sunday versus the Jaguars, but a PCL sprain in his left knee may be throwing a wrench into those plans.
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Kyle Pitts TE | ATL
Falcons' Kyle Pitts: Limited with toe injury
Pitts (toe) was limited in practice Wednesday, Tori McElhaney of the Falcons' official site reports.
Pitts was also limited by a toe issue last Thursday, though he sandwiched that session between two full practices and managed to avoid carrying an injury designation into Atlanta's loss to the Panthers in Week 3. He'll work to gain similar clearance for Sunday's contest against the Commanders. Through three games this season, Pitts has compiled 15 catches for 135 yards and zero touchdowns on 19 targets.
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Ricky Pearsall WR | SF
49ers' Ricky Pearsall: Not practicing Wednesday
Pearsall will miss Wednesday's practice due to a knee injury, David Lombardi of SFStandard.com reports.
Pearsall played 97 percent of San Francisco's offensive snaps in a 16-15 win over the Cardinals this past Sunday, catching eight of 11 targets for 117 yards. He's now third in the league in both receiving yards (281) and air yards (392), having caught four of seven targets 20-plus yards downfield. There is some chance the usage declines if Jauan Jennings (shoulder/ankle) now ends up healthier than Pearsall, but Jennings will also miss Wednesday's practice (after sitting out Weeks 1 and 3). The 49ers don't lack for injury concerns ahead of their home game against Jacksonville this Sunday.
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Brock Purdy QB | SF
49ers' Brock Purdy: To be limited Wednesday
Coach Kyle Shanahan said Purdy (left shoulder/toe) will be limited at Wednesday's practice, Matt Barrows of The Athletic reports.
The same can be said for fellow QB Mac Jones (knee), and the duo along with practice-squad member Adrian Martinez all will handle some first-team reps. Purdy has missed the past two games due to a turf toe variant and an AC joint sprain in his left shoulder, and how he fares on the field this week likely will determine who will be under center for the 49ers on Sunday against the Jaguars.
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Jauan Jennings WR | MIN
49ers' Jauan Jennings: Not practicing Wednesday
Jennings (ankle/shoulder) is not participating in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
Coach Kyle Shanahan said Jennings remains day-to-day and that he was close to being cleared to play Week 3 against the Cardinals, per David Lombardi of SFStandard.com. That said, it seems likely that Jennings will need to practice in at least a limited fashion Thursday and/or Friday to have a realistic shot at returning to the field Sunday versus the Jaguars. Jennings picked up a shoulder injury during San Francisco's regular-season opener but managed to play through it Week 2 before then picking up an ankle injury in the second game.
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Najee Harris RB | NYG
Chargers' Najee Harris: Officially on IR
The Chargers placed Harris (Achilles) on IR on Wednesday.
Coach John Harbaugh confirmed Monday that Harris suffered a torn Achilles during this past Sunday's win over the Broncos, and the running back will miss the remainder of the season as a result. In his absence going forward, Omarion Hampton is in line to lead the Chargers backfield, with Hassan Haskins in reserve and Kimani Vidal as well as Amar Johnson representing possible additions via the team's practice squad.
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Denzel Ward CB | CLE
Browns' Denzel Ward: Sits out practice Wednesday
Ward (shoulder/toe) is not practicing Wednesday, Scott Petrak of the Elyria Chronicle-Telegram reports.
Ward played 100 percent of snaps during Cleveland's win over the Packers in Week 3, but he's now sitting out practice due to a pair of injuries. He opened the prior practice week as limited due to shoulder and Achilles issues, so there's precedent for Ward's lack of practice reps simply being the result of load-management. Ward will have two more chances to get back on the practice field ahead of Sunday's road matchup against the Lions.
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D'Andre Swift RB | CHI
Bears' D'Andre Swift: Dealing with hip issue
Swift was limited in practice Wednesday due to a hip injury.
After he operated with a cap on his reps last week due to a quad issue, Swift was able to suit up this past Sunday against the Cowboys and turn his 16 touches into 78 yards from scrimmage. He did cede seven touches to rookie RB Kyle Monangai, while Roschon Johnson again stuck to special teams. In any case, Swift's status will be monitored as the week continues, and Friday's practice report will reveal whether or not he enters the weekend with a designation for Sunday's game at Las Vegas.
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Jalen Coker WR | CAR
Panthers' Jalen Coker: Still week-to-week
Coker (quadriceps) is making progress but is still considered week-to-week, Joe Person of The Athletic reports.
It sounds like Coker won't be ready to return from injured reserve when first eligible in Week 5. He was expected to miss four-to-six games all along, with his return likely to come at some point in October. With the Panthers not getting much from their pass catchers so far, Coker should push for a starting job before mid-season.
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Xavier Legette WR | CAR
Panthers' Xavier Legette: No practice Wednesday
Legette (hamstring) was a non-participant at Wednesday's practice.
Prior to being inactive Week 3, Legette was listed as limited on all three practice reports, so his downgrade to begin this week may be cause for concern. However, coach Dave Canales told Darin Gantt of the Panthers' official site Wednesday that Legette is considered "day-to-day," meaning the wide receiver's status will continue to monitored as the week goes on to get a sense of his chances to return to action Sunday in New England.