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Mario Edwards DT | HOU
Texans' Mario Edwards: Done for season with torn ACL
Edwards (knee) has been diagnosed with a torn ACL and will miss the remainder of the 2026 season, Jonathan M. Alexander of the Houston Chronicle reports.
Edwards was injured in Sunday's game against the Colts, and the 32-year-old will soon be headed to injured reserve. In three games this season, Edwards recorded six tackles (one solo), including 1.0 sacks, as a rotational defensive lineman for Houston.
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Jayden Reed WR | GB
Packers' Jayden Reed: Headed for injured reserve
The Packers are expected to place Reed (neck) on injured reserve Wednesday, Adam Schefter of ESPN reports.
Reed remains without a clear timeline for a return after sustaining a neck injury in the Packers' Week 2 win over the Jets that resulted in a brief stay in the hospital, but his impending move to IR ensures that he'll remain out for at least Green Bay's next four games. With Reed out indefinitely, second-year player Matthew Golden should be further insulated as the Packers' No. 2 receiver, while the likes of Skyy Moore, Bo Melton and J. Michael Sturdivant should see more involvement in three- and four-wide sets.
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David Moore WR | CAR
Panthers' David Moore: Inks to active roster
The Panthers signed Moore off the practice squad to the active roster Wednesday.
With Xavier Legette (knee) missing last Sunday's loss to the Browns, Moore was elevated from the practice squad for his 2026 debut in Week 3. Now that Jalen Coker (quadriceps) is also dinged up, Moore gets a spot on the 53-man roster after playing five offensive snaps and another 13 on special teams against Cleveland.
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Anthony Tyus III RB | CAR
Panthers' Anthony Tyus: Joins 53-man roster
The Panthers signed Tyus from the practice squad to the active roster Wednesday.
The 23-year-old running back made his regular-season NFL debut in Sunday's loss to the Browns, logging 14 snaps on special teams. He returned a pair of kicks for 47 yards and will now slot in behind Chuba Hubbard and AJ Dillon on the backfield depth chart.
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Mike Jackson CB | CAR
Panthers' Mike Jackson: Sent to injured reserve
The Panthers placed Jackson (groin) on injured reserve Wednesday.
Jackson was injured in Sunday's loss to the Browns, and will now miss at least the next four weeks. Carolina's secondary took a number of big hits in the injury department versus Cleveland, as Jaycee Horn suffered a torn quadriceps and will be out 6-to-12 weeks. Will Lee, Akayleb Evans and Chau Smith-Wade will handle cornerback duties for the foreseeable future.
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Jaycee Horn CB | CAR
Panthers' Jaycee Horn: Officially sent to IR
The Panthers placed Horn (quadriceps) on injured reserve Wednesday.
Horn suffered a torn quadriceps in Sunday's loss to the Browns and is expected to miss anywhere from 6-to-12 weeks. It's a brutal blow to the Carolina secondary, which will also be without Mike Jackson (groin) for at least the next four weeks after he was also placed on injured reserve Wednesday. Will Lee, Akayleb Evans and Chau Smith-Wade will handle cornerback duties moving forward.
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Brycen Tremayne WR | CAR
Panthers' Brycen Tremayne: Posts career-best yardage total
Tremayne finished with four receptions for 83 yards on six targets in Sunday's 21-18 loss to the Browns.
After playing less than 20 percent of the offensive snaps and failing to draw a target in either of the Panthers' first two games, Tremayne took on an expanded profile in the passing attack in Week 3 while Xavier Legette (knee) was inactive and Jalen Coker (quadriceps) made an early exit. Tremayne ended up playing 62 of the team's 77 offensive snaps (81 percent), leading Carolina in receiving with a career-best yardage total. However, if the Panthers get one or both of Coker and Legette back for Week 4 against the Lions, Tremayne is likely to see his playing time drop precipitously.
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Jalen McMillan WR | TB
Buccaneers' Jalen McMillan: Lands on IR
The Buccaneers placed McMillan (knee) on injured reserve Wednesday.
The move to IR officially rules McMillan out for the Buccaneers' next four games, but the wideout is projected to miss around 6-to-8 weeks after he sustained a PCL sprain of his left knee during Sunday's loss to the Vikings. With McMillan sidelined, rookie third-round pick Ted Hurst should be locked in as the Buccaneers' No. 3 wideout behind Emeka Egbuka and Chris Godwin.
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Jayden Daniels QB | WAS
Commanders' Jayden Daniels: To be limited in return to practice
Commanders head coach Dan Quinn said that Daniels (elbow) will be a limited participant in Wednesday's practice, John Keim of ESPN.com reports.
After arriving in London ahead of Sunday's game against the Colts, the Commanders are holding more of a jog-through session Wednesday, but Quinn noted that Daniels would be limited if the team had a traditional practice. Even a limited showing still amounts to progress for Daniels, who hadn't practiced in any fashion since sustaining a dislocated left elbow in a Sept. 20 loss to the Cowboys. Quinn hasn't closed the door on Daniels potentially suiting up for Sunday's contest, with the coach noting that he wants to see how the quarterback looks in practice over the next three days before settling on a Week 4 starter, per Nicki Jhabvala of The Athletic. Quinn also confirmed that whenever Daniels returns to action, the 25-year-old will wear a brace on his left elbow for added protection for the rest of the season, according to Zach Selby of the Commanders' official site.
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Rachaad White RB | WAS
Commanders' Rachaad White: Sitting out practice Wednesday
Commanders head coach Dan Quinn said that White (shoulder) won't participate in Wednesday's practice, Tashan Reed of The Washington Post reports.
White injured his shoulder late in the first half of Sunday's win over Seattle, but he was able to check back into the game in the third quarter and finished the day with eight carries for 35 yards and a six-yard touchdown reception. The running back is apparently still hurting a few days after the Week 3 contest and will receive treatment Wednesday, so his practice activity will warrant tracking the next two days to see if his shoulder issue affects his availability for Sunday's game against the Colts in London.