Smith (hamstring) has been ruled out for Sunday's game at the Rams.

Smith took 89 percent of snaps on offense in a 26-18 win over Washington this past Sunday, but he didn't practice at all this week and now is confirmed to be missing at least one game. His absence could push even more targets to WR A.J. Brown, TE Dallas Goedert and RB Saquon Barkley, as the leading candidates to take Smith's WR snaps (Jahan Dotson and Johnny Wilson) both have been targeted on less than 11 percent of their routes this year. Smith's next chance to play will come seven days later, Sunday, Dec. 1 at Baltimore in a battle between Mid-Atlantic heavyweights.

Al-Shaair (knee) has no injury designation ahead of Sunday's matchup against the Titans.

The first-year Texan practiced in a limited fashion both Wednesday and Thursday, but he upgraded to a full workload Friday, suggesting that he's recovered from his knee injury in time for Sunday's divisional matchup. With Al-Shaair back at full health, he's expected start alongside Henry To'oTo'o as part of Houston's top outside linebacker duo.

Stingley (hip) has no injury designation ahead of Sunday's matchup against the Titans.

Stingley practiced in full Friday after beginning the Texans' week of practice with back-to-back limited sessions, so it appears he's moved past his hip injury in time to suit up in Week 12. The third-year pro has impressed through Houston's first 11 games this season, recording 36 total tackles and 12 passes defended, including two interceptions. Expect Stingley to serve as the Texans' top outside cornerback in Sunday's divisional matchup.

Anderson (ankle) has no injury designation ahead of Sunday's matchup against the Titans.

The 23-year-old upgraded to full participation Friday after opening Houston's week of practice with consecutive limited sessions, suggesting that he's moved past his ankle issue in time for Sunday's divisional matchup. Expect Anderson to start opposite Danielle Hunter as part of the Texans' top pass-rushing duo in Week 12.

Fant (groin) is listed as questionable for Sunday's game against Arizona, Michael-Shawn Dugar of The Athletic reports.

Fant missed the past two games, sandwiched around a Week 10 bye, and just returned to practice Thursday as a limited participant. The Seahawks are giving him at least some chance to play ahead of a 4:25 p.m. ET kickoff Sunday, with rookie AJ Barner on hand to fill in again if needed. Barner drew 11 targets the past two games while playing 91 and 85 percent of snaps, but the big uptick in opportunities yielded just six catches for 42 yards.

Wirfs (knee/foot) is listed as questionable ahead of Sunday's matchup against the Giants, Jenna Laine of ESPN.com reports.

The 25-year-old offensive lineman sprained his right MCL in Tampa Bay's Week 10 loss to the 49ers and practiced in a limited fashion throughout the week. If Wirfs is unable to suit up for the Week 12 matchup, expect Justin Skule to protect Baker Mayfield's blindside.

Purdy (shoulder) isn't participating at the start of practice Friday afternoon, Cam Inman of The San Jose Mercury News reports.

Purdy was very limited Wednesday, threw only a few passes Thursday and may be missing practice Friday. The 49ers seem to be hoping rest will do the trick, but GM John Lynch acknowledged to Cam Inman of The San Jose Mercury News on Friday morning that the quarterback's Week 12 status is "tenuous" even after MRI results suggested he doesn't have a serious injury. Purdy injured his throwing shoulder during Sunday's loss to the Seahawks and now seems to be dealing with considerable soreness/discomfort.

Laube's set for a larger role Sunday against the Broncos, as Vic Tafur of The Athletic reports that both Alexander Mattison (ankle) and Zamir White (quad) will be listed as doubtful.

Laube fumbled on his only previous carry this season, but coach Antonio Pierce remains supportive of the 2024 sixth-round draft pick. According to Tafur, Laube and Sincere McCormick would back up Ameer Abdullah if Mattison and White both sit. McCormick would first have to be elevated from the practice squad, where the Raiders also have Chris Collier.

Smith (knee) is listed as doubtful ahead of Sunday's matchup against the Giants, Greg Auman of Fox Sports reports.

Scott Smith of the Buccaneers' official site reported earlier Friday that head coach Todd Bowles ruled out Smith for Sunday's matchup in New York. However, the Buccaneers' official injury report Friday lists the rookie from Georgia as doubtful. If Smith is sidelined as expected in Week 12, Tavierre Thomas and Troy Hill (ankle) will likely serve as Tampa Bay's top slot cornerbacks.

White (quadricep) will be listed as doubtful for Sunday's game against the Broncos, Tashan Reed of The Athletic reports.

The same goes for Alexander Mattison (ankle), which sets the stage for the Raiders to likely be without both players this weekend. If the duo is inactive versus Denver, Ameer Abdullah would be the expected starter at running back for Las Vegas, according to Reed, with Dylan Laube and practice-squad member Sincere McCormick also in the mix, per Vic Tafur of The Athletic.