Warren caught five of eight targets for 26 yards in Sunday's 38-30 loss to the Texans.

With Riley Leonard getting his first career start at quarterback, Warren wound up being nothing more than a security blanket and check-down option for his fellow rookie, with his longest gain going for just nine yards. The five receptions still led the Colts, however. Warren puts his first NFL season in the books with a 76-817-4 line on 112 targets, and depending on how the team solves its QB dilemma this offseason, the tight end could be poised for a Year 2 breakout.

Humphrey (illness) is active for Sunday's game against the Steelers.

Humphrey was tagged as questionable for Week 18 after missing Friday's practice due to an illness, but the veteran cornerback has progressed enough in his recovery over the weekend to be available for Sunday's pivotal AFC North clash. The 2017 first-rounder has logged 61 tackles (48 solo), including 1.0 sacks, 12 pass defenses (four interceptions), two forced fumbles and one fumble recovery across 14 regular-season games.

Lambert-Smith (hamstring) has been ruled out for the rest of Sunday's contest against the Broncos.

Lambert-Smith suffered a hamstring injury in the second quarter, and his night has now officially come to a premature end. Tre' Harris and Derius Davis could see a slight uptick in usage at wide receiver in his absence.

Kennedy (ribs) is questionable to return to Sunday's game against Chicago.

Kennedy suffered an injury to his ribs in the fourth quarter, and his status for the remainder of the contest is now up in the air. In his absence, Kalif Raymond and Jacob Saylors are top candidates to see added work at kick returner for Detroit.

Etienne rushed the ball 14 times for 32 yards in Sunday's 41-7 win over the Titans. He added one reception on one target for six yards.

Etienne had a very strong regular season, though Sunday served as a disappointing close. He logged a long rush of 11 yards, but eight of his 14 attempts on the ground picked up two or fewer yards. Etienne was also limited to only one target for just the third time this season and ultimately ended up with limited volume after being pulled early in the fourth quarter. If there was a positive point to note, he was able to surpass 1,100 rushing yards for the first time since 2022, his second season as a pro. Etienne should be in line for a bounce-back effort in the wild-card round, though it is still undetermined who the Jaguars will face.

Williams (hand) is questionable to return to Sunday's contest against the Bills.

Williams suffered an apparent hand injury in the third quarter, and his status for the rest of the game is now in question. In his absence, Mykal Walker is a top candidate to see increased reps at linebacker versus Buffalo.

Williamson (ankle) is questionable to return to Sunday's game against the Broncos.

Williamson has mostly served on special teams this season, but his absence depletes a Chargers secondary without the services of Derwin James (coach's decision) and Elijah Molden (hamstring) for Sunday's regular-season finale. The recently signed Marcus Maye should see more rotational snaps on defense for as long as Williamson is out of the game.

Pierce caught four of seven targets for 132 yards and two touchdowns in Sunday's 38-30 loss to the Texans.

With Riley Leonard getting his first career start at quarterback, Pierce stepped up as the rookie's top downfield option, hauling in a 66-yard score in the first quarter and an eight-yard TD in the second. The fourth-year wideout wasn't able to add to his numbers in the fourth quarter, however, getting ejected late in the third for making contact with an official while complaining about the lack of a pass interference call on a potential third touchdown. Pierce finishes 2025 with career highs in catches (47), yards (1,003) and targets (84) while scoring six TDs, but his fantasy appeal next year will depend a great deal on how the Colts solve their QB dilemma this offseason.

Calcaterra (ankle/knee) is questionable to return to Sunday's game against the Commanders.

Calcaterra appeared to sustain the injuries while being tackled by Jeremy Reaves in the third quarter, and the former was taken to the locker room to be evaluated by medical staff. Dallas Goedert (knee) is inactive, so Kylen Granson and Cameron Latu are in line for more offensive snaps at tight end for as long as Calcaterra is out of the game.

Taylor carried the ball 14 times for 26 yards and caught both his targets for 13 yards in Sunday's 38-30 loss to the Texans.

It was the least productive game of the season for Taylor, as his longest run went for only eight yards and rookie DJ Giddens wound up leading the Colts with 30 rushing yards. Taylor missed his chance to catch James Cook for the NFL rushing crown, but he still wraps up an impressive campaign with 1,585 rushing yards and a career-high 18 TDs on the ground, along with a 46-378-2 line on 55 targets through the air. The 26-year-old RB will head into 2026 as the centerpiece of the Indianapolis offense.