Cook carried the ball 15 times for 46 yards and caught two of three targets for five yards in the Bills' 27-24 win over the Jaguars during the wild-card round Sunday.

After amassing a career-high 1,621 yards during the regular season to secure his first career rushing crown, Cook had trouble finding room to roam against an elite Jags run defense, with his longest gain going for just 11 yards. Not counting a Week 18 contest in which he made only a cameo appearance, it was the first time Cook had been held below 50 yards since Week 11. The Bills won't know who they're playing next until after the weekend's games are over, but Cook is likely to face another tough opponent next weekend, with the Broncos and Texans among their potential divisional-round matchups.

Kittle was carted off the field during Sunday's playoff game against the Eagles after sustaining an apparent lower-leg injury, Adam Schefter of ESPN reports.

Per Jennifer Lee Chan of NBC Sports Bay Area, Kittle reached for his right lower leg after being tackled prior to his exit from the contest. At first glance, this doesn't look good for the tight end, with added context set to arrive once the 49ers make an official injury announcement.

Brown (hamstring) is questionable to return to Sunday's contest against the Eagles, Eric Branch of the San Francisco Chronicle reports.

Brown suffered a hamstring injury in the second quarter of the team's matchup with Philadelphia in the wild-card round. In his absence, Jason Pinnock and Marques Sigle are top candidates to see added snaps at safety.

Allen completed 28 of 35 passes for 273 yards and a touchdown while adding 33 rushing yards and two TDs on 11 carries in the Bills' 27-24 win over the Jaguars during the wild-card round on Sunday.

The superstar quarterback put Buffalo on his back once again, producing two of his three scores in the fourth quarter as the two teams traded the lead back and forth, including a one-yard plunge into the end zone with 1:04 left on the clock for the game-winning touchdown. Allen took a beating from the Jacksonville defense during the contest however, getting checked out in the blue medical tent twice, and he was seen limping in the locker room after the game per Joe Buscaglia of The Athletic. The Bills won't know who they're playing until after the weekend's games are over, but Allen will almost certainly play through whatever injuries he might have on the road in the divisional round. He's produced multiple TDs in five of his last six full games dating back to Week 13, racking up 14 scores (eight passing, six rushing) in total during that time with only two turnovers.

Davis (knee) was seen exiting the locker room on crutches and with a brace on his left leg after Sunday's 27-24 win over the Jaguars in the wild-card round, Alaina Getzenberg of ESPN.com reports.

Davis was ruled out after being carted off the field during the second half, as he suffered a left knee injury that appears to be significant. Davis logged 12 catches (on 18 targets) for 129 yards and a touchdown over six regular-season appearances in 2025. His status will be worth monitoring for the Bills' upcoming divisional-round matchup against an opponent to be determined.

Striggow exited Sunday's wild-card game versus the Bills with an ankle injury.

Striggow missed two straight games with an ankle injury before returning for the Week 18 win over Tennessee. The 23-year-old didn't record a statistic before exiting Sunday's playoff game. In his absence, Dawuane Smoot likely will see increased playing time behind starting defensive ends Josh Hines-Allen and Travon Walker.

Mekari is questionable to return to Sunday's wild-card game versus the Bills due to a back injury.

Mekari missed the final two games of the regular season with a back issue, but he did not carry an injury designation coming into Sunday's contest. Jacksonville is also without starting left tackle Cole Van Lanen (knee), who is inactive.

Williams (hamstring) is active for Sunday's wild-card game versus the Eagles.

Williams sustained a hamstring injury during Week 17 that left him sidelined for the regular-season final versus Seattle. The star left tackle will suit up for Sunday's playoff contest, which should be a significant factor for both San Francisco's rushing attack and pass blocking.

Davis won't return to Sunday's game against the Jaguars after sustaining a knee injury.

Prior to being carted off the field Sunday, Davis caught two of his three targets for 14 yards. His absence leaves Khalil Shakir, Brandin Cooks, Tyrell Shavers and Keon Coleman to handle Buffalo's WR duties versus Jacksonville.

White (groin/hamstring) is active for Sunday's wild-card game versus Philadelphia.

White has dealt with groin and hamstring injuries during practice this week, but he increased his activity to participate in a limited fashion Friday. The 26-year-old has seen heavy playing time as a rotational pass rusher in 2025, tallying 12 tackles and 5.0 sacks across nine regular-season games with the 49ers.