Double-A Corpus Christi placed Spence on its 7-day injured list April 22 due to an unspecified injury.
The 23-year-old outfielder slashed .267/.382/.311 with zero home runs and two stolen bases over 55 plate appearances on the season for Corpus Christi before landing on the shelf.
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Astros' Lucas Spence: Included in Monday's lineup
Rotowire
Spence (neck) will start in left field and bat seventh in Monday's Grapefruit League game against the Nationals, Matt Kawahara of the Houston Chronicle reports.
Spence will check back into the Astros' spring lineup after a neck issue and kept him out of action since Tuesday. Regarding as one of the top position prospects in the organization, Spence is likely to open the 2026 season at Double-A Corpus Christi or Triple-A Sugar Land.
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Astros' Lucas Spence: Scratched with neck issue
Rotowire
Spence was scratched from Thursday's Grapefruit League lineup against the Cardinals due to a neck injury, Brian McTaggart of MLB.com reports.
Spence had been slated to start in center field and bat sixth, but he'll be replaced by Ethan Frey instead. Consider Spence -- who is slated to begin the 2026 season in the minors -- day-to-day for now.
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Astros' Lucas Spence: Climbs three levels this year
Rotowire
Spence has a .246/.369/.403 slash line with nine home runs, 24 steals, a 14.1 percent walk rate and a 24 percent strikeout rate in 110 games across Single-A, High-A and Double-A this season.
Spence was a two-way player in community college and in the Ohio Valley Conference before signing with the Astros in 2024 as an undrafted free agent. He has focused on developing as an outfielder in pro ball, demonstrating a strong eye at the plate and plus speed on the bases. The lefty hitter would presumably face a platoon role initially in the majors, but his strong swing decisions and defensive utility could get him a look in 2026 or 2027.