The Philadelphia Eagles will host the Pittsburgh Steelers during the Week 15 NFL schedule in a potential Super Bowl preview with how well both teams are playing. The Eagles (11-2) have secured a spot in the NFL playoff bracket and would clinch the NFC East with a win and Washington Commanders loss. The Steelers (10-3) lead the Baltimore Ravens by two games in the AFC North, while the Eagles and Steelers are coming off wins last week. The Eagles are 5.5-point favorites in the latest Week 15 NFL odds according to the SportsLine Consensus, while the over-under is 43 points. The Commanders are favored by 7.5 at New Orleans in the latest NFL Vegas odds, with an over-under of 44. Should you include either side of these Week 15 NFL spreads in your Week 15 NFL parlay picks?

Another interconference matchup with significant playoff implications takes place with the Los Angeles Chargers hosting the Tampa Bay Buccaneers, with the Chargers as three-point favorites in the Week 15 NFL betting lines, unchanged from the open. Tampa Bay leads the NFC South at 7-6, while Los Angeles is 8-5 and battling for an AFC Wild Card spot after the Kansas City Chiefs clinched the AFC West last week. Can you expect Los Angeles to bounce back from a last-second field goal loss in your Week 15 NFL betting strategy? Before you make any Week 15 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2024 NFL season on an incredible 25-11 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 205-139 roll on top-rated NFL picks that dates back to the 2017 season and a 59-32 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns.

Now, the model has scoured the Week 15 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 15 NFL picks at SportsLine.

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Top Week 15 NFL picks

After simulating every game 10,000 times, the model is high on the Denver Broncos (-4, 44) to cover against the Indianapolis Colts. The Broncos enter rested off a bye following a three-game winning streak, most recently defeating the Cleveland Browns, 41-32, in Week 13 Monday Night Football. After dropping their first two games of the season, the Broncos are on an 8-3 run overall and they are 10-3 ATS on the season. Meanwhile, the Colts are 2-4 overall and ATS over their last six games. 

Bo Nix was the fifth quarterback selected in the 2024 NFL Draft, taken No. 12 overall, but he's playing like someone who could have been selected at the top spot. Nix has thrown for more than 270 yards in three straight games, including 294 yards against the Brown in Week 13. He has seven touchdowns compared to two interceptions during that span and he leads all rookie quarterbacks in passing yards (2,842) this season. The model expects another strong game from Nix and it projects the Broncos to cover the spread in 62% of simulations. See which other NFL parlay picks to make here.

How to make Week 15 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including three teams that win by double-digits, covering the spread with ease. You can only see the model's Week 15 NFL best bets and NFL parlay at SportsLine.

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What are the model's top Week 15 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 15 NFL best bets from a model on an 205-139 run on top-rated picks, and find out.