The debut of Christian McCaffrey could happen on Sunday. The 28-year-old could be ready to return from his calf/Achilles injury, so should he be an immediate part of your Week 10 NFL DFS strategy against the Buccaneers? Jordan Mason has been productive without McCaffrey, but is there any value in him for NFL DFS lineups if the team's clear RB1 is back? Before making any NFL DFS picks for Sunday or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine's advanced NFL DFS Lineup Optimizer.

The DFS Optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups confidently with injury updates, floor and ceiling player projections, and Vegas lines and picks all with one winning tool for sports betting apps.

Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2024 NFL Week 10 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

Top NFL Week 10 DFS picks for Sunday

One of the Optimizer's top DFS value picks for Sunday is Chiefs quarterback Patrick Mahomes ($6,600 on DraftKings and $7,900 FanDuel). It's crazy to think given his status as most people's choice for the best quarterback in the NFL, but Mahomes hasn't been a viable Fantasy football quarterback the majority of the season. That changed last week when Mahomes showcased his newest weapon in DeAndre Hopkins. Mahomes threw for 291 yards and three touchdowns in a 30-24 overtime victory over the Buccaneers with Hopkins having eight receptions for 86 yards and two scores.

Mahomes was QB3 in Fantasy football last week after being QB20 on a points-per-game basis over the first eight weeks. He had his best Fantasy football performance of the season last week, aided by Travis Kelce reaching 100 yards for the first time this year. The Chiefs play the Broncos on Sunday and Mahomes has thrown for more than 300 yards in three of his last four games against Denver. 

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The Optimizer's NFL DFS strategy also includes rostering Vikings running back Aaron Jones ($6,700 on DraftKings and $7,900 FanDuel). Jones rushed for 64 yards and added four receptions for 18 yards last week against the Colts. He's been a focal point in the surprisingly efficient Vikings offense this season with more than 90 rushing yards in four of eight games this year.

The Vikings have the No. 8 scoring offense (26.1 points per game) this season ahead of a matchup against the Jaguars, who rank 30th in scoring defense at 28 ppg. The Jaguars are 31st in yards allowed (389.3 per game) and have especially struggled against running backs. The Jaguars are allowing the third-most Fantasy football points to opposing running backs this season in what could be a huge performance for Jones. You can see the rest of the Optimizer's NFL DFS picks here.

How to build Sunday Week 10 NFL DFS lineups

The Optimizer is also targeting multiple undervalued players who could explode for huge numbers on Sunday. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the Optimizer's NFL DFS picks, at SportsLine

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So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice and stacks, all from an NFL DFS Optimizer that simulates every game 10,000 times, and find out.