NFL odds, Vegas lines, picks, spreads, game predictions: Model loves Ravens, Buccaneers in Week 2, 2024

SportsLine's advanced model has locked in its Week 2 NFL betting picks from 10,000 simulations

By CBS Sports Staff

Sep 14, 2024 at 10:01 am ET • 3 min read

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Home-field advantage is alive and well in the NFL, with hosts winning 11 of 16 games last week and going 9-7 against the spread. However, there are six road favorites on the Week 2 NFL schedule, including the Chargers (-5) at the Panthers. Los Angeles began the Jim Harbaugh era with a 22-10 win over the Raiders in Week 1, while Carolina head coach Dave Canales' first game as a head coach ended in a 47-10 demolition by the Saints. The Panthers were 3-4-1 against the spread as a home underdog in 2023, so which side should you back as you make your Week 2 NFL predictions and NFL bets? All of the Week 2 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 2 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on A-rated NFL picks since its inception. The model enters Week 2 of the 2024 NFL season on an incredible 184-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 38-22 roll on A-rated NFL picks since Week 7 of the 2022 NFL season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 2 NFL odds and NFL betting lines on the spread, money line, and over-under, and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 2 NFL predictions

We can tell you one of the model's strongest Week 2 NFL picks is that the Ravens (-8.5, 41.5) cover at home versus the Raiders. Baltimore is coming off a hard-fought 27-20 loss against Kansas City in the NFL Kickoff Game where an Isaiah Likely touchdown catch as time expired was overturned because his foot was on the line. John Harbaugh had already indicated his team would go for the two-point conversion and the win if the call had stood, but now the Ravens will have to dust themselves off and get back on track in another matchup with an AFC West opponent.

The Raiders opened their season with a 22-10 loss to the Chargers where they simply couldn't stop Jim Harbaugh's rushing attack. Las Vegas yielded 176 rushing yards and will now have to deal with a Baltimore offense that ran for 185 yards in the opener. Lamar Jackson and Derrick Henry are a thunder and lightning tandem in the Ravens' backfield and the model is predicting that those two help Baltimore cover in well over 50% of simulations. See which other teams to pick here.

Another one of its Week 2 NFL predictions: the Buccaneers (+7.5, 51.5) cover on the road versus the Lions. After improving by six wins in Dan Campbell's second season, the Lions were pegged for big things in 2023 and took a step towards the NFL's upper echelon by tying a franchise record with 12 wins and making it to the 2024 NFC Championship Game. However, nobody saw Tampa Bay coming last season after Tom Brady retired.

Baker Mayfield went from stopgap option at quarterback to signing a $100 million extension this offseason and he dazzled in a Week 1 win over Washington. Mayfield went 24-of-30 for 289 yards and four touchdowns in a 37-20 win by the Bucs. With that passing game clicking on all cylinders early, the model is predicting that Tampa Bay covers the spread in 60% of simulations. See which other teams to pick here.

How to make Week 2 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 2 NFL schedule and just revealed four coveted A-rated picks against the spread. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence, and which four A-rated NFL against-the-spread picks should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.