The Week 6 college football schedule continues Friday night, and two ranked teams are in action as No. 25 UNLV hosts Syracuse and No. 6 Oregon hosts Michigan State, with both games beginning at 9 p.m. ET. The latest Week 6 college football odds via SportsLine consensus list the Rebels at -6.5 and the Ducks at -23.5 in their respective matchups. That leads into another full Saturday slate that is highlighted by a noon ET matchup between No. 9 Missouri and No. 25 Texas A&M (-2) as the only ranked matchup.
Some other playoff contenders will be tested on the road with No. 12 Ole Miss (-8) at South Carolina, No. 4 Tennessee (-13.5) at Arkansas and No. 10 Michigan (+1.5) at Washington in a rematch of last year's title game. Before locking in any Week 6 college football picks, be sure to see the top Week 6 college football expert picks, predictions and best bets from Thomas Casale.
A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. Over the past two college football seasons, Casale is 122-92-5 (57%) overall on his college football picks and 26-8 (76.4%) in bowl games -- all publicly documented. Anybody who has followed him is way up.
Now, he has turned his attention to the Week 6 college football odds and is sharing his top three best bets. If you parlay them together, you could be looking at a return of around 6-1. Get his top college football picks at SportsLine.
Top Week 6 college football expert predictions
One of Casale's top Week 6 college football picks: He is backing Stanford (+8) to cover at home against Virginia Tech in an ACC matchup at 3:30 p.m. ET on Saturday.
Casale believes this could be a buy-low spot on Stanford after its blowout loss last week, while Virginia Tech has a tough task bouncing back from a heartbreaker against Miami and heading across the country for this one.
"Stanford lost to Clemson 40-14, but the Cardinal have been competitive in every other game this season," Casale told SportsLine. "Head coach Troy Taylor has built up the roster in his two years on The Farm and I like playing this team as a home dog. I believe the market still hasn't caught up with Stanford yet and there is value with the Cardinal." See what other picks Casale likes at SportsLine.
How to make Week 6 college football picks
Casale has also found two other college football picks he loves, including backing an underdog he says will cover and "potentially win outright." You can only see his picks at SportsLine.
What are the best bets for Week 6 of college football, and which underdog should you be all over? Visit SportsLine now to see Thomas Casale's college football best bets, all from a proven college football handicapper who has gone 26-8 on bowl games the past two seasons, and find out.