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The No. 5 Indiana Hoosiers were not on many radars heading into the season, but they have established themselves as national championship contenders heading into their matchup against the No. 2 Ohio State Buckeyes on Saturday during the Week 13 college football schedule. Indiana improved to 10-0 with a 20-15 win over Michigan two weeks ago before having a week off to prepare for the Buckeyes. The Hoosiers are 13-point road underdogs in the Week 13 college football odds, as Ohio State has won its last two games by a combined score of 76-7. Which side of that Week 13 college football spread should you back with your Week 13 college football bets?

No. 18 Army is also unbeaten heading into the weekend, but it will face its first ranked opponent when it travels to No. 8 Notre Dame. The Black Knights are 14.5-point underdogs in the Week 13 college football lines in what is the only other ranked vs. ranked matchup this week. Before locking in any Week 13 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a strong 21-15 on all top-rated picks over the past eight weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

Now, it has turned its attention to the latest college football odds and Week 13 college football betting lines. Head here to see every pick.

Top college football predictions for Week 13 

One of the college picks the model is high on during Week 13: No. 16 Colorado (-2.5) covers the spread on the road against Kansas in a 3:30 p.m. ET matchup on Saturday. The Buffaloes have taken another big step forward under head coach Deion Sanders this year, winning eight of their first 10 games to put themselves in a tie with BYU atop the Big 12 standings. They extended their winning streak to four games with a 49-24 win over Utah last week, marking their sixth double-digit win of the season. 

Senior quarterback Shedeur Sanders has 3,222 passing yards and 31 total touchdowns, helping Colorado cover the spread in eight consecutive games. Junior wide receiver Travis Hunter has 74 receptions for 911 yards and nine scores while also playing elite defense, establishing himself as the Heisman Trophy favorite heading into Week 13. Kansas has been an inconsistent team throughout the season, which is why Colorado is covering the spread in well over 50% of the model's simulations. See the rest of its Week 13 college football picks here. 

Another prediction: No. 15 Texas A&M (-2.5) keeps its College Football Playoff hopes alive with a win at Auburn in a 7:30 p.m. ET kickoff on Saturday. The Aggies bounced back from a loss at South Carolina with a 38-3 win over New Mexico State last week, as freshman quarterback Marcel Reed threw two touchdown passes and ran for a third score. Reed has provided a spark for Texas A&M's offense since taking over the starting job in a huge win against LSU at the end of October. 

The Aggies have already won two road games in SEC play, beating Florida and Mississippi State by double digits. Auburn has lost five of its first six league games, including a 17-7 loss to Vanderbilt at home earlier this month. Texas A&M has a massive motivational edge as it tries to keep its CFP chances alive, and the model has the Aggies covering the small spread in over 60% of simulations. See picks for every other game in Week 13 here.

How to make college football picks for Week 13

The model has also made the call on who wins and covers in every FBS matchup in Week 13, and it's calling for a whopping 12 underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which 12 underdogs win outright in Week 13? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.

College football odds for Week 13

See full Week 13 college football picks, odds, predictions here

Wednesday, Nov. 20

Buffalo at Eastern Michigan (-1, 52)

Ohio at Toledo (-1.5, 45)

Thursday, Nov. 21

NC State at Georgia Tech (-8.5, 52)

Friday, Nov. 22

Temple at UTSA (-16.5, 56)

Purdue at Michigan State (-13.5, 47.5)

UNLV at San Jose State (+7.5, 62)

Saturday, Nov. 23

Ole Miss at Florida (+10, 55.5)

Wake Forest at Miami (-24.5, 64.5)

Indiana at Ohio State (-13, 51.5)

Colorado at Kansas (+2.5, 59.5)

Kentucky at Texas (-20.5, 47)

Penn State at Minnesota (+11.5, 45)

Army at Notre Dame (-14.5, 44.5)

Boise State at Wyoming (+22.5, 57.5)

Texas A&M at Auburn (+2.5, 46.5)

Alabama at Oklahoma (+13.5, 47.5)