No. 14 Kansas State already turned in what will be viewed one of the most impressive performances on the Week 3 college football schedule as it demolished No. 20 Arizona 31-7 on Friday, easily covering as 7-point favorites. There's only one other ranked matchup this week as No. 6 Missouri hosts No. 24 Boston College. The latest Week 3 college football odds via SportsLine consensus list the Tigers as 14.5-point favorites.
Other Week 3 college football lines of note include No. 4 Alabama (-16.5) vs. Wisconsin, No. 9 Oregon (-17) vs. Oregon State and top-ranked Georgia (-22) against Kentucky. Before locking in any Week 3 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.
The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen strong returns!
Now, it has turned its attention to the latest college football odds and Week 3 college football betting lines on the spread, money line and over/under. Head here to see every pick.
Top college football predictions for Week 3
One of the college football picks the model is high on during Week 3: Washington (-5.5) covers in its Apple Cup rivalry game at Washington State in a 3:30 p.m. ET on Saturday. The Apple Cup has been one-sided over the past decade, as Washington is 9-1 straight up and 7-3 against the spread in the last 10 meetings. The Huskies are playing under a new coaching staff following their run to the national championship game last season, but they are off to a strong start with blowout wins over Weber State and Eastern Michigan.
Transfer quarterback Will Rogers has already racked up 511 passing yards and five touchdowns, while transfer running back Jonah Coleman has rushed for 231 yards and three scores. They are facing a Washington State defense that allowed 30 points to FCS Portland State in Week 1, and the Cougars are going on the road for the first time this season. Washington has consistently been the better team in this rivalry, and the model has the Huskies covering the spread in well over 60% of simulations. See the rest of its Week 3 college football picks here.
Another prediction: No. 5 Ole Miss (-21) covers the sizable spread at Wake Forest in a 6:30 p.m. ET kickoff on Saturday. Dave Clawson's Demon Deacons missed a bowl game for the first time since 2015 last season and now they're coming into a tough matchup off a 31-30 loss to open ACC play against Virginia. Wake Forest gave up 357 yards through the air in that defeat and now they'll take on one of the most prolific passing offenses in the country.
Lane Kiffin's Rebels have thrown for an outlandish 926 yards in wins over Furman (an FCS playoff squad from a season ago) and Middle Tennessee, with starting quarterback Jaxson Dart averaging 14.7 yards per pass attempt. However, Ole Miss isn't a one-trick pony offensively either, as it averages 250.3 yards per game on the ground as well. This will be the toughest test yet for the Rebels, but they very well may have the best offense in the country and the model predicts that Ole Miss covers in well over 60% of simulations. See picks for every other game in Week 3 here.
How to make college football picks for Week 3
The model has also made the call on who wins and covers in every FBS matchup in Week 3, and it's calling for an underdog to win outright in a primetime game. You can only get every pick for every game at SportsLine.
So what college football picks can you make with confidence, and which underdog wins outright in one of the biggest games in Week 3? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $2,000 in profit since its inception, and find out.
College football odds for Week 3
See full Week 3 college football picks, odds, predictions here
Saturday, Sept. 14
LSU at South Carolina (+6, 48)
Alabama at Wisconsin (+16.5, 48.5)
Boston College at Missouri (-14.5, 53.5)
Texas A&M at Florida (+3.5, 45.5)
Tulane at Oklahoma (-13, 46.5)
Oregon at Oregon State (+17, 49.5)
Washington State at Washington (-5.5, 54.5)
Notre Dame at Purdue (+7.5, 47.5)
Colorado at Colorado State (+7.5, 58.5)