Leonard (coach's decision) is inactive for Sunday's game against the Rams but will serve as the Colts' emergency third-string quarterback.

Leonard has been Indy's emergency third-string quarterback for every game so far this season. He will only be eligible to enter the game if both Daniel Jones and Anthony Richardson are forced out due to injury, illness or ejection.

Jones (knee) is active for Sunday's contest against the Jaguars, Briana Jeannel of the 49ers' official site reports.

Jones emerged from his second consecutive start in place of Brock Purdy (left shoulder/toe) last Sunday against the Cardinals with a sprained PCL in his left knee. The issue limited Jones' practice reps this week, and he entered the weekend listed as questionable, while coach Kyle Shanahan announced Purdy as the 49ers' starting QB on Friday. When the team didn't elevate practice-squad member Adrian Martinez on Saturday, it signaled that Jones was in line to serve as Purdy's backup, which now has been confirmed.

Wentz completed 30 of 46 passes for 350 yards and two touchdowns with two interceptions in Sunday's 24-21 loss to the Steelers in Dublin. He added 12 rushing yards on two carries and also threw a two-point conversion to Jalen Nailor.

The Vikings lost right tackle Brian O'Neill to a knee injury and center Ryan Kelly to a concussion in the first half, and Wentz was under constant pressure as a result, getting sacked six times in total. Minnesota headed into the fourth quarter staring at a 21-6 deficit, but Wentz was able to lead a comeback that fell just short, hitting Zavier Scott for a 16-yard TD and Nailor for a two-yard score inside the final four minutes. On the other hand, the veteran QB almost threw a third INT in crunch time, only to have it overturned upon review. With J.J. McCarthy (ankle) not quite 100 percent yet, Wentz is expected to get another start in London for a Week 5 clash with the Browns, but he'll need to take better care of the ball to have a shot at retaining the job when the Vikings return from Europe.

Winston (coach's decision) is listed as inactive but available as the Giants' emergency third quarterback Sunday versus the Chargers, Dan Salomone of the Giants' official site reports.

While Winston will retain his role from the first three games of the season, the top of New York's QB depth chart has changed Week 4, with Jaxson Dart poised for his first NFL start and Russell Wilson handling backup duties. Winston will see the field only if Dart and Wilson suffer injuries.

DeVito (coach's decision) is the Patriots' inactive emergency third QB for Sunday's game against the Panthers.

In that context, Joshua Dobbs will continue to serve as Drake Maye's top backup in Week 4. Look for DeVito to remain the team's emergency No. 3 QB as long as Maye and Dobbs both remain healthy.

Howell (coach's decision) is inactive but available as the Eagles' emergency third quarterback Sunday in Tampa Bay.

Howell served as Philadelphia's backup signal-caller to Jalen Hurts in the first three games of the season with Tanner McKee recovering from a broken thumb. Now that McKee can handle the No. 2 role, Howell will move to No. 3 and only see if the field if both Hurts and McKee leave Sunday's contest due to injury.

Mayfield (right biceps) is listed as active Sunday against the Eagles.

Mayfield operated with a cap on his reps during Week 4 prep due to a right biceps injury and wasn't seen throwing passes until Friday's practice. Despite entering the weekend as questionable, he'll lead the Buccaneers offense as he normally does Sunday, with Chris Godwin (foot) swapping in for an absent Mike Evans (hamstring) at wide receiver. Godwin is making his season debut after completing his recovery from the dislocated left ankle that he suffered Week 7 of the 2024 campaign, so he may not be running on all cylinders for at least a few games. In any case, Mayfield's top available skill-position talents will be RB Bucky Irving, WRs Godwin, Emeka Egbuka and Sterling Shepard and TE Cade Otton.

Daniels (knee) will remain out for Sunday's game in Atlanta but is expected to return to action in the Commanders' Week 5 road matchup with the Chargers on Oct. 5, Ian Rapoport of NFL Network reports.

Daniels turned in a pair of limited practices this week, but the Commanders are opting to hold the second-year signal-caller out for a second straight game while he manages a knee sprain. Though Marcus Mariota will once again start for Washington, Daniels' knee responded well to a workout Saturday, leaving the Commanders optimistic that the 24-year-old will be ready to go next week for a tough matchup with the undefeated Chargers. Whether Daniels enters the Week 5 contest with or without an injury designation will hinge on his practice activity next Wednesday through Friday.

Head coach Aaron Glenn told reporters Saturday that Fields (concussion) will start against the Dolphins on Monday, Adam Schefter of ESPN reports.

Fields was sidelined for Sunday's loss to the Buccaneers after being diagnosed with a concussion following the Jets' Week 2 loss to the Bills. Fields was a full participant in practice Thursday and Friday and has cleared the league's five-step concussion protocol, per Cameron Wolfe of NFL Network. That paves the way for the 2021 first-rounder to start in Monday's AFC East clash while Tyrod Taylor reverts to QB2 duties. Fields has opened the regular season completing 19 of 33 passes for 245 yards and one touchdown while adding 17 carries for 97 yards and two scores across two games.

Mayfield (right biceps) is expected to play Sunday against the Eagles, ESPN's Adam Schefter reports.

Mayfield, who was limited at practice this week, is officially listed as questionable, with coach Todd Bowles having previously noted Friday that the quarterback "should be OK for Sunday." Also trending toward active status versus Philadelphia is wide receiver Chris Godwin (ankle), and the duo's Week 4 status, either way, is set to be confirmed ahead of the first wave of games Sunday, with the Buccaneers kicking off at 1:00 p.m. ET.