Rourke (knee) had his 21-day practice window opened Monday by the 49ers.

Rourke has been sidelined since late August while on the reserve/non-football injury list with a pre-existing knee injury from his final college campaign with Indiana. The team will now have 21 days to activate him from the NFI list, or he'll be forced to sit out the remainder of the season.

Rypien, who is on the Indianapolis pratice squad, could be in line to start this week at Seattle with Daniel Jones out with a torn Achilles tendon and Riley Leonard's status uncertain due to a knee injury. "Right now, (Rypien would) be the guy that's on our roster. Like I said, we're working through those situations right now," head coach Shane Steichen told the Indianapolis Star.

Indianapolis may have no choice other than to call up Rypien from the practice squad and take over starting quarterback duties. Rypien was with Minnesota during training camp, but he was cut in late August and subsequently joined Cincinnati's practice squad. The veteran QB was signed to the Bengals' active roster after Joe Burrow (toe) went on IR in mid-September, but Rypien got into just one game with the Bengals, playing three offensive snaps without attempting a pass in Week 3. Rypien then was released by Cincinnati and subsequently signed with Indianapolis.

Leonard sustained a strained right knee ligament in Sunday's 36-19 loss to the Jaguars and is considered week-to-week, Adam Schefter of ESPN reports.

Pressed into duty after Daniel Jones suffered a season-ending Achilles injury early in Sunday's contest, Leonard completed 18 of 29 passes for 145 yards, no touchdowns and one interception while adding five yards and a touchdown in his first extended NFL action. Though he's expected to take over as the Colts' starter in place of Jones, Leonard will first have to prove that the knee issue isn't severe enough to keep him sidelined Week 15 against the Seahawks. Even if Leonard is ultimately cleared to play, Indianapolis will almost certainly have to bring in quarterback depth this week, and reports have recently emerged that 44-year-old Philip Rivers will be brought in for a workout Tuesday.

Howell (coach's decision) is inactive but operating as the Eagles' emergency third quarterback for Monday night's contest against the Chargers.

Howell is set to serve as the team's No. 3 option at QB behind starter Jalen Hurts and backup Tanner McKee, a role he's operated in throughout the season. Howell has yet to appear in a regular-season game, and both Hurts and McKee would have to be sidelined for him to do so in Week 14.

Herbert (left hand) is listed as active for Monday night's game against the Eagles, Eric Smith of the Chargers' official site reports.

Herbert, who sustained a fracture in his left (non-throwing) hand during Week 13 action against the Raiders and underwent surgery to address the issue last Monday, had approached the contest listed as questionable after being limited in practice Thursday through Saturday. With his active status confirmed, Herbert is in line to continue to helm a Chargers offense that will be bolstered by the return of RB Omarion Hampton (ankle) from IR. It remains to be seen if/how Herbert's injury will affect his ability to handle snaps versus Philadelphia, with the QB on track to wear a glove and protective guard on his injured hand, per Daniel Popper of The Athletic. Trey Lance is next in line for signal-caller snaps should Herbert suffer any setbacks.

Coach Dan Quinn noted Monday that Daniels is "sore" following Week 14 action, but added that there are no "long-term concerns" with the QB's left (non-throwing) elbow, Nicki Jhabvala of The Washington Post reports.

Per Ben Standig of Big 100 Washington D.C., Quinn previously relayed that Daniels (left elbow) could have returned to Sunday's 31-0 loss to Vikings after exiting the contest, but it was a coach's decision to keep the signal-caller on the sideline. That said, Quinn indicated Monday that Daniels will be monitored ahead of Sunday's game against the Giants, with the QB's Week 15 status yet to be determined.

Coach Shane Steichen noted Monday that "the hope" is Leonard (right knee) will be able to play Sunday against the Seahawks, James Boyd of The Athletic reports.

At this stage, Steichen can't say for certain that Leonard will be available this weekend, which means that current practice squad member Brett Rypien may be pressed into duty in Week 15. In any case, it seems likely that the Colts will bring in another QB in short order, with Daniel Jones out for the season with an Achilles' injury and Anthony Richardson (orbital) still on IR.

Coach Shane Steichen confirmed Monday that Jones sustained a torn right Achilles during Sunday's loss to the Jaguars.

The quarterback will miss the remainder of the 2025 season and is slated to undergo surgery within the next week, per Steichen. Sixth-round rookie Riley Leonard, who replaced Jones Sunday, is also dealing with a knee injury of his own, James Boyd of The Athletic reports. While Steichen thinks Leonard will be able to play in Week 15 against the Seahawks, that's not a lock to happen. With Anthony Richardson (orbital fracture) still on IR and not in line to be activated this week, practice squad member Brett Rypien could end up drawing the start instead of Leonard. In his first campaign with Indianapolis, Jones had been re-establishing himself as a viable QB1, throwing for 3,101 yards with a 19:8 TD in 13 games to go along with 45 carries for 164 yards and five rushing TDs. The 28-year-old is facing a lengthy rehab, and considering that he's on track to become a free agent this offseason, his future with the Colts is uncertain.

Richardson (orbital) will not be activated from injured reserve this week, Kevin Bowen of 107.5 The Fan Indianapolis reports.

The Colts find themselves in need of options at the quarterback spot with Daniel Jones (Achilles) out for the season and Riley Leonard (knee) also banged up, but Richardson will not be one of them immediately, as his recovery continues from the orbital fracture he sustained in mid-October. Brett Rypien -- who is on the practice squad -- is the only Colts quarterback without an injury concern heading into Week 15.

Leonard is dealing with a knee injury, Kevin Bowen of 107.5 The Fan Indianapolis reports.

Leonard replaced an injured Daniel Jones (Achilles) in Sunday's contest and finished out the game, but it appears he picked up an injury of his own. The extent of the injury is not yet known. With Jones out for the season and Anthony Richardson (orbital) on injured reserve, practice-squad quarterback Brett Rypien is currently the only healthy Colts quarterback option.