Knight (ankle) is listed as questionable for Sunday's game against the 49ers, Darren Urban of the Cardinals' official site reports.

The Cardinals listed Knight as a limited practice participant Wednesday through Friday, following his early exit from a 44-22 loss to the Seahawks in Week 10. He worked as Arizona's lead rusher before the injury -- a reverse from Week 9 when Emari Demercado got 14 carries -- but Knight gained just 33 total yards on 11 touches before his fourth-quarter exit at Seattle. The lack of role consistency/certainty in Arizona's backfield will make Knight a shaky fantasy option even if he avoids the inactive list before a 4:05 p.m. ET kickoff this Sunday.

Dobbins (foot) remained sidelined at practice Friday, Chris Tomasson of The Denver Gazette reports.

Dobbins hasn't practiced this week and is trending toward being ruled out later Friday, per Tomasson. If that ends up being the case, 2025 second-rounder RJ Harvey would be in line to lead Denver's backfield Sunday against the Chiefs, with Tyler Badie and Jaleel McLaughlin available to work in complementary roles.

Mitchell could see added opportunities Sunday against the Browns, as Justice Hill (toe) was ruled out Friday.

Derrick Henry is the clear leader in Baltimore's backfield, but the speedy Mitchell should get some chances in a change-of-pace role. Mitchell's averaging 6.2 yards per carry on a limited sample of 15 rushes in 2025, as opportunities have been hard to come by behind Henry and Hill.

Jones (shoulder/toe) doesn't have an injury designation for Sunday's matchup with the Bears, Adam Caplan of SiriusXM NFL Radio reports.

Jones played through the same two injuries during last week's 27-19 loss to Baltimore, taking 72 percent of offensive snaps while turning 15 touches into 69 yards and a TD. He handled a similar portion of Minnesota's backfield work a week earlier in the upset win over Detroit, prior to exiting in the second half with an AC joint sprain. The shoulder injury may continue to limit his practice reps some, but Jones did manage a full session Friday to close out the week, suggesting he's all systems go for a home game against the Bears.

Hill (toe) has been ruled out for Sunday's game against the Browns.

After not practicing Wednesday or Thursday, Hill returned to a limited practice Friday, but he'll sit this one out and target a possible return to action Sunday, Nov. 23 against the Jets. In Hill's absence versus Cleveland, Keaton Mitchell and Rasheen Ali will be available to handle Week 11 backfield touches that don't go to Baltimore's top RB, Derrick Henry.

Wright was signed from the Buccaneers' practice squad to the active roster Friday, Scott Smith of the team's official site reports.

The Monmouth product's signing provides Tampa Bay with much-needed depth at running back, as Bucky Irving (foot/shoulder) is in line to miss his sixth consecutive game in Week 11. Expect Wright to play a depth role in the Buccaneers' backfield Sunday, potentially contributing on offense and special teams.

Pacheco (knee) has been ruled out for Sunday's game against the Broncos.

With Pacheco, who last saw game action Week 8, still sidelined, Kareem Hunt is poised to continue to lead the Chiefs backfield this weekend, while Brashard Smith, Elijah Mitchell and potential practice-squad elevation Clyde Edwards-Helaire available to mix in. Pacheco's next chance to see game action will occur Sunday, Nov. 23 against the Colts. While filling in for Pacheco in a Week 9 loss to the Bills (prior to Kansas City's bye), Hunt carried 11 times for 49 yards and a touchdown while catching one of two targets for six yards. In that contest, Smith logged three carries for seven yards, and Edwards-Helaire rushed twice for five yards.

Hunt is poised to lead Kansas City's backfield Sunday against the Broncos, as Isiah Pacheco (knee) has been ruled out.

Pacheco will miss a second consecutive game sandwiched around Kansas City's Week 10 bye. In Pacheco's absence, Hunt recorded 55 yards from scrimmage and a touchdown on 12 touches Week 9 against the Bills. Brashard Smith will be available in a change-of-pace role but recorded only three carries in Buffalo.

Perine (ankle) has been ruled out for Sunday's game against the Steelers.

With Perine -- who didn't practice this week -- unavailable and targeting a return to action Sunday, Nov. 23 against the Patriots, Tahj Brooks is in line to serve as Chase Brown's top backup this weekend. The Bengals also have the option of elevating RBs Gary Brightwell and/or Kendall Milton from their practice squad ahead of Week 11 action.

Coach Andy Reid said Pacheco (knee) didn't practice Friday, Pete Sweeney of ArrowheadPride.com reports.

Pacheco hasn't practiced since taking a hit to the side of his right knee during a Week 8 win against the Commanders, after which he was diagnosed with a sprained MCL. He thus appears destined to be ruled out for a second game in a row coming out of the Chiefs' Week 10 bye. Kareem Hunt will continue to lead the backfield for as long as Pacheco is sidelined.