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Dalvin Cook RB | DAL
Vikings' Dalvin Cook: Scores twice in win
Cook rushed 18 times for 94 yards and two touchdowns in Sunday's 29-22 win over the Bears. He also caught both of his targets for 27 yards.
Cook opened the scoring with a one-yard plunge during the first quarter, before punching in a five-yard touchdown to begin the second. Along with totaling his third game with at least 90 yards on the ground, Cook's couple catches helped him set a season high for scrimmage yards thus far. With his performance contributing toward the Vikings now sitting in first place in the NFC North, Cook approaches Week 6's matchup versus the Dolphins in fine form.
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Keaontay Ingram RB | KC
Cardinals' Keaontay Ingram: Debut delayed again
Ingram (coach's decision) is listed as inactive Sunday against the Eagles, Darren Urban of the Cardinals' official site reports.
With the rest of Arizona's backfield healthy and available, Ingram's pro debut again will have to wait until Week 6, at the earliest. The rookie sixth-round pick is taking a seat while James Conner serves as the team's lead runner, Eno Benjamin and Darrel Williams are around for any touches that don't go to Conner, and Jonathan Ward handles his customary special-teams role.
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Rashaad Penny RB | CAR
Seahawks' Rashaad Penny: Hurts left ankle Sunday
Penny suffered a left ankle injury during Sunday's game in New Orleans, Brady Henderson of ESPN.com reports.
Penny picked up the health concern on a carry during Seattle's first possession of the second half and needed a cart to get to the locker room. If he's unable to reenter the contest, he'll come out of Week 5 with eight rushes for 54 yards. Rookie second-round pick Kenneth Walker and DeeJay Dallas are the remaining healthy running backs on the active roster.
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Jonathan Williams RB | WAS
Commanders' Jonathan Williams: Won't return Sunday
Williams has been ruled out for the remainder of Sunday's game against the Titans due to a knee injury.
Williams played primarily on special teams before leaving the contest in the second half due to a knee injury. The Commanders have a short week and play again Thursday, so the knee injury could hinder the running back's availability for Week 6 as well.
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Rashaad Penny RB | CAR
Seahawks' Rashaad Penny: Injures left leg Sunday
Penny was carted to the locker room during Sunday's game at New Orleans due to an injury to his lower left leg, Brady Henderson of ESPN.com reports.
Penny was examined by the Seahawks' training staff on the team's first drive of the second half before the decision was made to take him to the locker room. If he's unable to return, he'll finish Week 5 with eight carries for 54 yards.
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Boston Scott RB | PIT
Eagles' Boston Scott: Inactive Sunday
Scott (ribs) is inactive for Sunday's game against the Cardinals, Sage Hurley of the Eagles' official site reports.
With Scott still out this week, Kenneth Gainwell and Trey Sermon are in line to continue to log complementary snaps behind top back Miles Sanders, who racked up 27 carries in the Eagles' Week 4 win over the Jaguars.
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Tony Pollard RB | TEN
Cowboys' Tony Pollard: Playing Sunday
Pollard (illness) is active for Sunday's contest at the Rams, Todd Archer of ESPN.com reports.
An illness kept Pollard off the practice field Friday, but he was able to travel with the team to L.A. and now has been cleared for Week 5 action. He'll continue to work in a complementary role alongside Ezekiel Elliott, which has featured two outings with at least 90 yards from scrimmage and two others with fewer than 25 total yards this season.
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Ty Chandler RB | NO
Vikings' Ty Chandler: Will not return
Chandler is out for the remainder of Sunday's game against the Bears with a hand injury.
Chandler was active for just the second time in his rookie season Sunday. However, he still has not seen the ball on offense. He'll work to be back Week 6 against the Dolphins.
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Marlon Mack RB | ARI
49ers' Marlon Mack: Healthy inactive Week 5
Mack (coach's decision) is inactive for Sunday's Week 5 clash against the Panthers.
The veteran back garnered active status for the last two games but logged only a combined five special-teams snaps, and he'll now sit out altogether Sunday. In his stead, Tevin Coleman, who was promoted from the practice squad Saturday, will serve as the No. 3 running back behind Jeff Wilson and Jordan Mason against Carolina.
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Damien Harris RB | BUF
Patriots' Damien Harris: Injures hamstring Sunday
Harris (hamstring) won't return to Sunday's game against the Lions.
With Pierre Strong inactive Sunday, Rhamondre Stevenson will handle the Patriots' RB duties for the rest of the contest. Harris, who carried four times for 11 yards prior to his exit, will target a possible return to action in Week 6 against the Browns.