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Mac Jones QB | SF
49ers' Mac Jones: Suiting up Sunday, but as backup QB
Jones (knee) is active for Sunday's contest against the Jaguars, Briana Jeannel of the 49ers' official site reports.
Jones emerged from his second consecutive start in place of Brock Purdy (left shoulder/toe) last Sunday against the Cardinals with a sprained PCL in his left knee. The issue limited Jones' practice reps this week, and he entered the weekend listed as questionable, while coach Kyle Shanahan announced Purdy as the 49ers' starting QB on Friday. When the team didn't elevate practice-squad member Adrian Martinez on Saturday, it signaled that Jones was in line to serve as Purdy's backup, which now has been confirmed.
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Tyler Higbee TE | LAR
Rams' Tyler Higbee: Garners active status Sunday
Higbee (hip) is active for Sunday's Week 4 matchup against the Colts, Sarah Barshop of ESPN.com reports.
The veteran tight end had put in a full session Wednesday before apparently suffering a hip injury in Thursday's practice and then missing Friday's session, an absence head coach Sean McVay termed a veteran rest day. Higbee indeed will be in uniform Sunday and attempt to get more mileage out of his No. 1 tight end role, which thus far this season has only netted a 4-37-0 line on six targets over three games.
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Ricky Pearsall WR | SF
49ers' Ricky Pearsall: Active in Week 4
Pearsall (knee) is listed as active Sunday against the Jaguars, Briana Jeannel of the 49ers' official site reports.
A knee injury hampered Pearsall in practice during Week 4 prep, resulting in a DNP on Wednesday and limited sessions Thursday and Friday. On Wednesday, the second-year pro told Jennifer Lee Chan of NBC Sports Bay Area that he'd play that day if there was a game, and now that Sunday has arrived, he'll be out there as he normally is for the 49ers offense. Considering fellow WR Jauan Jennings (ankle/shoulder) reportedly will have his snaps monitored, per Adam Schefter of ESPN, Pearsall is lined up to be Brock Purdy's (left shoulder/toe) top pass catcher in the quarterback's return to action.
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Dyami Brown WR | WAS
Jaguars' Dyami Brown: Inactive Sunday
Brown (shoulder) is inactive for Sunday's game against the 49ers.
Brown, who exited the Jaguars' 17-10 win over the Texans in Week 3 after recording 23 snaps and two catches for seven yards on three targets, approached the contest listed as questionable after practicing in a limited fashion Thursday and Friday. In his absence Sunday, Brian Thomas, Travis Hunter and Parker Washington are on track to lead the Jaguars' wideout corps versus San Francisco, with Washington (who saw 11 targets in Week 3) representing a lineup pivot for those scrambling for help at the WR position in Week 4.
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Jauan Jennings WR | MIN
49ers' Jauan Jennings: Returning to action Sunday
Jennings (ankle/shoulder) is active for Sunday's game versus the Jaguars, Briana Jeannel of the 49ers' official site reports.
Jennings was gutting out a shoulder injury in the later stages of Week 1 and all of Week 2, but in the latter contest, he picked up an ankle injury that sidelined him Week 3 and didn't allow him to practice until Friday in a limited capacity. While he'll be available to the 49ers offense Sunday, there's an expectation that his snaps will be monitored, per Adam Schefter of ESPN. As a result, managers may want to pivot to a healthier option until Jennings is able to handle a typical workload, even with QB Brock Purdy (left shoulder/toe) back in action.
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Davante Adams WR | LAR
Rams' Davante Adams: Active against Colts
Adams (hamstring) is active for Sunday's Week 4 game against the Colts, Sarah Barshop of ESPN.com reports.
The veteran wideout was able to get in a limited practice Friday after sitting out the first two sessions of the week, and Adams has now validated head coach Sean McVay's optimism that he'd be able to suit up and fill his usual No. 2 role against Indianapolis. Adams thus has far proven an ideal complementary fit in the Rams' air attack alongside No. 1 receiver Puka Nacua, posting a 13-213-2 line on 29 targets through his first three contests.
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DeForest Buckner DT | SF
Colts' DeForest Buckner: Good to go Week 4
Buckner (back) is active for Sunday's game against the Rams.
A back injury limited Buckner's practice participation this past week, but he has been cleared to play in Sunday's road game. The veteran defensive lineman has registered 14 tackles (nine solo) through the first three games of the regular season.
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Cam Jackson DT | CAR
Panthers' Cam Jackson: Exits with knee injury
Jackson is questionable to return to Sunday's game against the Patriots due to a knee injury, Darin Gantt of the Panthers' official site reports.
Jackson was able to walk off the field under his own power, and he'll have his knee injury monitored by medical staff to determine whether he can return. The Panthers would be down to just four defensive linemen if Jackson is unable to play, with Tershawn Wharton serving in rotation behind A'Shawn Robinson, Bobby Brown and Derrick Brown.
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Kerby Joseph SAF | DET
Lions' Kerby Joseph: Questionable to return Week 4
Joseph is questionable to return to Sunday's game against the Browns due to a knee injury.
Joseph appeared to injure his knee on the same play that D.J. Reed picked off Joe Flacco in the second quarter. Joseph was helped off the field by two trainers to avoid putting pressure on his leg before being taken to the locker room, per Colton Pouncy of The Athletic. Thomas Harper will likely see more snaps at safety alongside Brian Branch for as long as Joseph is sidelined.
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Cedric Tillman WR | NO
Browns' Cedric Tillman: Hurts hamstring Sunday
Tillman won't return to Sunday's game against the Lions after sustaining a hamstring injury.
Tillman approached the contest without an injury designation after being limited Wednesday and Thursday by listed hand and hip issues, so Sunday's hamstring injury is something new for the wideout. Prior to his exit, Tillman caught one of his two targets for six yards. In his absence, Isaiah Bond, Jamari Thrash and DeAndre Carter are available to handle WR snaps that don't go to Jerry Jeudy.