NFL Player News

James (coach's decision) is inactive for Sunday's game against the Saints, Briana Jeannel of the 49ers' official site reports.

The rookie fifth-rounder broke his finger in early August and was not cleared to play against the Seahawks in Week 1. James was able to fade an injury designation ahead of Sunday's game after logging a full practice Friday, but he'll observe the contest in street clothes while the 49ers roll with a three-man backfield of Brian Robinson, Isaac Guerendo and starter Christian McCaffrey. James' next chance to make his NFL regular-season debut is Week 3 against the Cardinals on Sunday, Sept. 21.

Nunez-Roches (foot) is inactive for Sunday's game against the Cowboys, Dan Salomone of the Giants' official site reports.

Nunez-Roches popped up on Thursday's injury report as a limited practice participant due to a foot injury before being downgraded to a DNP on Friday. The injury will prevent him from playing in Sunday's NFC East clash, and his next chance to see the field is Week 3 against the Chiefs on Sunday, Sept. 21. Elijah Garcia and rookie third-rounder Darius Alexander are in line to see a significant increase in defensive snaps due to Nunez-Roches' injury.

Brown (ankle) won't suit up for Sunday's Week 2 matchup versus Cincinnati.

Brown entered the weekend with a designation of doubtful, so it's no surprise that he's not going to play against the Bengals. The fourth-year defensive back did manage to log a trio of limited practices this week, so he could be ready to make his season debut next Sunday against Houston.

Worthy (shoulder) has been ruled out ahead of Sunday's game against the Eagles, but the Chiefs believe the receiver is "looking good" to play Week 3 against the Giants, Ian Rapoport of NFL Network reports.

Despite suffering a full tear of his right labrum during a collision with teammate Travis Kelce on the first drive of the Chiefs' 27-21 season-opening loss to the Chargers on Sept. 5, Worthy was able to practice in a limited fashion Thursday and Friday and took a doubtful tag into the weekend before the Chiefs downgraded him to out for the Week 2 matchup. Worthy could still require surgery for the injury down the road, but for the time being, he plans to play through the issue while wearing a harness to protect the torn labrum. The Chiefs will wait and see how Worthy fares during their upcoming practices in Week 3 before deciding on his availability for the showdown with the Giants, but the early expectation is that he'll be ready to play following a one-game absence.

Vaki (hamstring) is inactive for Sunday's game against the Bears.

The running back was listed as doubtful for the matchup after missing Week 1 with the same injury. Vaki played mostly as a special teamer in 2024, as Detroit's crowded backfield of Jahmyr Gibbs, David Montgomery and Craig Reynolds made it hard to get offensive snaps. The second-year pro is in line for a similar role once he returns.

Johnson (quadriceps) is inactive for Sunday's matchup against the Jets.

Johnson dealt with a quad injury during the practice week and logged a DNP/LP/LP progression. He was deemed questionable heading into the weekend and will be held out against New York. Fellow cornerback Jordan Hancock (shoulder) is also inactive Sunday, so Cam Lewis will be asked to start in the slot.

Parkinson (shoulder) is inactive for Sunday's game against the Titans.

Parkinson sprained the AC joint in his shoulder in the first half of the Rams' Week 1 win over the Texans. The injury prevented the 2020 fourth-rounder from practicing all week, and he will observe Sunday's game in street clothes while Davis Allen and Terrance Ferguson serve in depth roles at tight end behind Tyler Higbee. Parkinson's next chance to play is Week 3 against the Eagles on Sunday, Sept. 21.

DeVito (coach's decision) is inactive but will serve as the Patriots' emergency third quarterback against the Dolphins on Sunday.

DeVito will be New England's emergency quarterback for a second consecutive week after he was claimed off waivers in late August. As the emergency QB3, DeVito is not allowed to play unless Drake Maye and Joshua Dobbs are both removed from Sunday's contest due to injury, illness or ejection.

Williams (knee) is active for Sunday's matchup with the Saints, Briana Jeannel of the 49ers' official site reports.

The starting left tackle was listed as a non-participant in practice Wednesday and Thursday before logging a limited session Friday, though his absences were described as rest days and not injury related. Williams has started every game he's played in since joining the 49ers in 2020.

Winston (coach's decision) is inactive for Sunday's game against the Cowboys but is serving as the Giants emergency quarterback.

First-round rookie Jaxson Dart will again work as the backup to starter Russell Wilson, with Winston continuing to suit up as the emergency No. 3 quarterback. Wilson struggled in his Giants debut last week, and Dart could get an opportunity if those struggles continue Sunday. Winston, however, can only take the field in Dallas if both Wilson and Dart are injured.