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Chris Rodriguez Jr. RB | JAC
Commanders' Chris Rodriguez: Healthy scratch Sunday
Rodriguez (coach's decision) is inactive for Sunday's game against the Giants.
Rodriguez thus is the odd man out in a Commanders backfield that will be playing without Brian Robinson following his trade to the 49ers on Aug. 22. Instead, some combination of Austin Ekeler, rookie seventh-round pick Jacory Croskey-Merritt and Jeremy McNichols will be Washington's available running backs Sunday. Rodriguez's next chance to suit up will be Thursday at Green Bay.
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Quinn Ewers QB | JAC
Dolphins' Quinn Ewers: Serving as emergency QB in Week 1
Ewers is inactive and will work as Miami's emergency third quarterback Sunday versus Indianapolis.
Ewers is third in the Dolphins' QB pecking order, so his inactive status comes as no surprise. In order for the 2025 seventh-round draft selection to be eligible to enter Sunday's contest, both Tua Tagovailoa and Zach Wilson would need to be sidelined due to injury, illness or ejection.
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Tommy DeVito QB | NE
Patriots' Tommy DeVito: QB3 for Week 1
DeVito (coach's decision) is inactive but will serve as the Patriots' emergency third-string quarterback against the Raiders on Sunday.
As the emergency quarterback, DeVito will be allowed to see the field only in the event that both Drake Maye and Joshua Dobbs are removed from Sunday's contest. DeVito failed to make the Giants' 53-man roster at the end of training camp but was claimed off waivers by the Patriots in late August to provide depth at quarterback.
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Efton Chism III WR | NE
Patriots' Efton Chism: Inactive for opener
Chism is inactive for Sunday's season opener against the Raiders.
Chism secured a roster spot with a strong preseason, but his NFL regular-season debut is on hold for now. In Week 1, Stefon Diggs, DeMario Douglas, Kayshon Boutte, Mack Hollins and Kyle Williams will handle the Patriots' WR duties.
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Will Mallory TE | IND
Colts' Will Mallory: Healthy inactive
Mallory is inactive for Sunday's season opener against Miami due to a coach's decision, James Boyd of The Athletic reports.
Mallory had a good showing in training camp by all accounts, but he enters the season fourth on the depth chart at tight end and may not be active most game days. Mallory has receiving skills, but no tight end other than Tyler Warren may be a significant factor in the passing game.
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Kyler Murray QB | MIN
Cardinals' Kyler Murray: Suiting up Sunday despite illness
Murray (illness) is listed as active for Sunday's game at New Orleans, Darren Urban of the Cardinals' official site reports.
The Cardinals tacked on Murray to their Week 1 injury report Sunday morning due to an illness, but there was an expectation all along he'd be able to suit up. Whether or not he'll be able to make it through the entire game unscathed remains to be seen, but if Murray needs to step off the field at any point, Jacoby Brissett is on hand to direct Arizona's offense in such a scenario.
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D'Wayne Eskridge WR | MIA
Dolphins' Dee Eskridge: Cleared to play Week 1
Eskridge (concussion) is active for Sunday's game against the Colts.
Eskridge was limited in practice all week, but he has passed the league's five-step concussion protocol and will play in Sunday's regular-season opener in Indianapolis. Eskridge appeared in six regular-season games for the Dolphins in 2024 and logged three catches (on as many targets) for 44 yards while adding 146 kick return yards.
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Jermaine Burton WR | CIN
Bengals' Jermaine Burton: Surprise Week 1 scratch
Burton (coach's decision) is inactive for Sunday's game against the Browns, Paul Dehner Jr. of The Athletic reports.
Burton had a tumultuous rookie season but had gotten strong reviews for improvement throughout the offseason. That makes it particularly surprising that he'll be inactive for Week 1, though Charlie Jones and Mitchell Tinsley -- both active-- are set to serve as depth wide receivers and special teams contributors on Sunday.
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Riley Leonard QB | IND
Colts' Riley Leonard: Emergency QB for Week 1
Leonard (coach's decision) is inactive for Sunday's game against the Dolphins but will serve as the emergency third-string quarterback.
The rookie sixth-rounder will be allowed to see the field only if both Daniel Jones and Anthony Richardson were removed from Sunday's game due to injury. Leonard had a solid preseason, completing 34 of 56 passes for 345 yards, one touchdown and one interception across three games while adding seven carries for 58 yards.
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Raheem Mostert RB | LV
Raiders' Raheem Mostert: Not playing Week 1
Mostert (coach's decision) is a healthy inactive for Sunday's game against New England.
Mostert's inactive status comes as a surprise, as he's not known to be dealing with an injury and was listed as the Raiders' RB2 or RB3 on the team's initial Week 1 depth chart, per Vincent Bonsignore of the Las Vegas Review-Journal. With Mostert out of action, Las Vegas will go with Zamir White and Dylan Laube as the active running backs behind rookie starter Ashton Jeanty.