The college football world will turn its attention to Tuscaloosa on Saturday night when No. 4 Alabama hosts No. 2 Georgia in the biggest game on the Week 5 college football schedule. Alabama has cruised to three blowout wins to open the season, while Georgia entered the season as the top-ranked team and crushed then-No. 14 Clemson in its opener. The Bulldogs are 2-point road favorites in the Week 5 college football odds for a game that will have massive implications in the SEC title race and College Football Playoff picture. Which powerhouse should you back with your Week 5 college football bets?
Other ranked vs. ranked matchups this week include No. 23 Kansas State (-6) vs. No. 20 Oklahoma State, No. 16 Notre Dame (-4.5) vs. No. 15 Louisville and No. 9 Penn State (-17.5) vs. No. 19 Illinois. No. 1 Texas (-38.5 vs. Mississippi State) and No. 3 Ohio State (-25 at Michigan State) are both huge favorites in their respective Week 5 college football spreads. Before locking in any Week 5 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.
The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns!
Now, it has turned its attention to the latest college football odds and Week 5 college football betting lines on the spread, money line and over/under. Head here to see every pick.
Top college football predictions for Week 5
One of the college football picks the model is high on during Week 5: No. 16 Notre Dame (-4.5) picks up a double-digit win over No. 15 Louisville in a 3:30 p.m. ET matchup on Saturday. The Fighting Irish suffered a shocking loss to Northern Illinois at home earlier this month, but they have responded with blowout wins over Purdue and Miami (OH). They handed the Boilermakers their most lopsided loss in their 137-year history, racing out to a 42-0 halftime lead in a 66-7 win.
Notre Dame narrowly failed to cover the spread in its 28-3 win over Miami (OH) last week, and it is getting set for another home game this week. Louisville has yet to play a road game this season, making this a difficult scheduling spot for the Cardinals. They are just 6-13 in their last 19 road games, which is one reason why the model has Notre Dame covering the spread in well over 60% of simulations. See the rest of its Week 5 college football picks here.
Another prediction: No. 21 Oklahoma (-3) notches a comfortable road win at Auburn in a 3:30 p.m. ET kickoff on Saturday. The Sooners will be motivated to get back on track following their 25-15 loss to then-No. 6 Tennessee last week. They struggled to get anything going offensively under sophomore quarterback Jackson Arnold, but they had more success when they replaced Arnold with freshman Michael Hawkins Jr. late in the first half.
Hawkins completed 11 of 18 passes for 132 yards and a touchdown while rushing for 22 yards. Head coach Brent Venables has not named a starter for this game, but Hawkins gives Oklahoma a promising young option at quarterback. Auburn has dropped two of its last three games and is coming off a double-digit home loss to Arkansas, so the model has Oklahoma covering the spread well over 60% of the time. See picks for every other game in Week 5 here.
How to make college football picks for Week 5
The model has also made the call on who wins and covers in every FBS matchup in Week 5, and it's calling for a whopping 10 underdogs to win outright, including an upset in one of the biggest games of the week. You can only get every pick for every game at SportsLine.
So what college football picks can you make with confidence, and which 10 underdogs win outright in Week 5? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.
College football odds for Week 5
See full Week 5 college football picks, odds, predictions here
Thursday, Sept. 26
Friday, Sept. 27
Virginia Tech at Miami (-17, 55.5)
Washington at Rutgers (-2.5, 46.5)
Saturday, Sept. 28
Oklahoma State at Kansas State (-6, 55)
Kentucky at Ole Miss (-17.5, 53)
Minnesota at Michigan (-10, 39)
Louisville at Notre Dame (-4.5, 48)
Mississippi State at Texas (-38.5, 61.5)
Ohio State at Michigan State (+25, 49.5)
Georgia at Alabama (+2, 49.5)
Illinois at Penn State (-17.5, 47.5)