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Carlos Santana 1B | ATL
Royals' Carlos Santana: On base four times Thursday
Santana went 1-for-3 with three walks and two runs scored in Thursday's 14-10 win over the Rangers.
There was no shortage of offense Thursday, and Santana did his part to keep the line moving. He scored on a Kyle Isbel single in the first inning and a Hunter Dozier fielder's choice in the seventh. Santana also added an RBI single in the third. The 34-year-old first baseman is known for having a good batting eye -- he posted a .349 on-base percentage in 255 plate appearances last season despite a batting average of just .199. There's still some power in his bat, too, so fantasy managers who can cover his drag on average could benefit from utilizing Santana. He hit third in Thursday's game and figures to remain in the heart of the order for most of the year.
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Anthony Rizzo 1B | NYY
Cubs' Anthony Rizzo: Doubles on Opening Day
Rizzo went 1-for-3 with a double and an RBI in Thursday's loss to the Pirates.
Chicago managed just two hits all day, with Rizzo and Eric Sogard both recording doubles. The veteran first baseman batted third, and when his talented teammates get going, he should be able to rack up plenty of runs and RBI from his prime lineup spot.
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Donovan Solano 1B | TEX
Giants' Donovan Solano: Starting Thursday
Solano is starting Thursday's game against the Mariners, Maria I. Guardado of MLB.com reports.
Solano should serve primarily as a backup to begin the year with Tommy La Stella and Brandon Belt available, but he'll start against left-hander Marco Gonzales on Opening Day. The veteran will play second base and bat third against the Mariners.
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Kole Calhoun 1B | CLE
Diamondbacks' Kole Calhoun: Placed on injured list
Calhoun (knee) was placed on the 10-day injured list Thursday.
Calhoun underwent knee surgery in March but has still been making good progress while participating in baseball activities. However, the 33-year-old will miss at least the first two series of the regular season while he recovers. Pavin Smith is starting in right field for Thursday's game against the Padres, but Tim Locastro could also see increased playing time in Calhoun's absence, especially against left-handed pitchers.
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Justin Bour 1B | SF
Giants' Justin Bour: Headed to minor-league camp
Bour did not make the Giants' Opening Day roster and will head to minor-league camp as expected, Maria Guardado of MLB.com reports.
After spending 2020 in Japan, Bour was not a part of big-league spring training. He'll serve as organizational depth at first base. The 32-year-old shouldn't be expected to see much time in the majors this year.
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Carlos Santana 1B | ATL
Royals' Carlos Santana: Batting third in opener
Santana will start at first base and bat third in Thursday's season opener versus the Rangers.
Adalberto Mondesi initially looked on track to begin the season as the Royals' No. 3 hitter, but his placement on the injured list Wednesday due to an oblique strain has opened the door for Santana to slot in between Andrew Benintendi and Salvador Perez in the batting order. After signing a two-year, $17.5 million deal with Kansas City over the winter, the 34-year-old turned in a productive spring, posting a .949 OPS while drawing 11 walks against nine strikeouts.
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Asdrubal Cabrera 1B | CIN
Diamondbacks' Asdrubal Cabrera: Starting Thursday
Cabrera is starting Thursday's game against the Padres.
The veteran infielder hit .326 with three home runs this spring and will enter the starting lineup against the Padres on Opening Day with Nick Ahmed (knee) sitting out. Cabrera will play third base and bat fifth against San Diego.
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Andrew Vaughn 1B | MIL
White Sox's Andrew Vaughn: Not starting Opening Day
Vaughn won't start Opening Day against the Angels on Thursday with Leury Garcia working in left field and Zack Collins batting eighth as the designated hitter, James Fegan of The Athletic reports.
The White Sox recently announced the 22-year-old made the team's Opening Day roster, so it's a bit of a surprise the organization's top prospect won't be in the lineup Opening Day. Vaughn is expected to be in the starting nine as the designated hitter Friday with southpaw Andrew Heaney pitching for the Angels. Vaughn saw more work in left field during spring training and could see time there this season with Eloy Jimenez (pectoral) set to miss most of 2021.
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Luke Voit 1B | NYM
Yankees' Luke Voit: Shifts to injured list
Voit (knee) was placed on the 10-day injured list Wednesday, retroactive to March 29.
The 30-year-old underwent surgery to repair a partially torn meniscus Monday, so it was only a matter of time before he landed on the shelf. Voit doesn't have an officially timeline for his return, but he'll likely be sidelined from baseball activities for a few weeks. He shouldn't be expected to make his season debut in April.