Lowe went 1-for-4 with an RBI double and three strikeouts in Wednesday's 4-2 loss to the Blue Jays.

Lowe struck out in each of his first three plate appearances (twice looking), but he didn't leave Wednesday's game empty handed after driving a double to right field in the ninth inning to bring James Wood across home plate. Lowe has gone 7-for-23 with two home runs and six RBI in the first six games of the season, though he's struck out 13 times across 25 plate appearances.

Freeman (ankle) isn't in the lineup for Wednesday's game versus Atlanta, David Vassegh of AM 570 LA Sports reports.

Wednesday will mark the third straight game Freeman has missed since aggravating his right ankle injury while in the shower over the weekend. Enrique Hernandez will pick up another start at first base and bat eighth while Freeman continues to recover. The eight-time All-Star will get an extra day to rest up with the team day off Thursday, though his status for Friday's series opener in Philadelphia remains up in the air.

Toglia will start at first base and bat sixth in Wednesday's game against the Phillies.

The first baseman began the season as the Rockies' No. 5 hitter, but he's been bumped down a spot for the last two contests while Colorado has moved the hot-hitting Hunter Goodman up in the lineup. Toglia has gotten off to a slow start to the season, going 1-for-15 with eight strikeouts through the Rockies' first four games.

Solano will start at first base and bat sixth in Wednesday's game against the Tigers.

Solano will pick up his third start of the season, all of which have come at first base and when the Mariners have gone up against left-handed pitching. The 37-year-old looks like he'll be limited to a short-side platoon role while Rowdy Tellez and Luke Raley are healthy and available to serve as the primary options at first base and designated hitter, respectively.

Raley is out of the lineup for Wednesday's game against the Tigers.

Raley and fellow left-handed hitter Rowdy Tellez will move to the bench for the series finale while the Tigers send southpaw Tarik Skubal to the hill. With Raley getting the afternoon off, Cal Raleigh will occupy the designated-hitter spot while Mitch Garver fills in for Raleigh behind the plate.

Tellez is out of the lineup for Wednesday's game against the Tigers.

The Tigers are sending southpaw Tarik Skubal to the hill, so Tellez and fellow left-handed hitter Luke Raley will hit the bench as the Mariners add a couple of extra right-handed bats to the lineup. Donovan Solano will step in for Tellez at first base.

Wade is absent from the lineup for Wednesday's game in Houston.

Left-hander Framber Valdez will start for the Astros, so the lefty-hitting Wade will begin the series finale on the bench. Casey Schmitt will fill in at first base and bat fifth.

Busch is out of the lineup for Wednesday contest against the Athletics.

Southpaw Jeffrey Springs is on the bump for the Athletics, so the left-handed-hitting Busch will begin the series finale on the bench. Justin Turner will start at first base and bat cleanup for the Cubs.

Vaughn is not in the lineup for Wednesday's game against the Twins.

It's the first day off this season for Vaughn, who is 3-for-19 with a home run in the first five contests. Nick Maton will start at first base and bat leadoff for the White Sox on Wednesday.

Burleson is out of the lineup for Wednesday's game against the Angels.

Through the first six games of the season, the Cardinals have faced left-handed starting pitchers two times, and the lefty-hitting Burleson has checked out of the lineup on both occasions. The right-handed-hitting Luken Baker will replace Burleson as the Cardinals' designated hitter Wednesday while southpaw Yusei Kikuchi takes the hill for the Angels.