The Blue Jays selected Espino's contract from Triple-A Buffalo on Friday, Hazel Mae of Sportsnet reports.

The 37-year-old right-hander will give the Jays a fresh long relief arm, taking Wes Parsons' spot on the roster. Espino has collected a 5.01 ERA in 94 appearances (41 starts) over parts of five major-league seasons.

Loaisiga was placed on the 60-day injured list by the Yankees on Friday, retroactive to April 4, with a right flexor strain.

Per Greg Joyce of the New York Post, manager Aaron Boone said it's a "significant" strain. Loaisiga will meet with doctors Friday, and surgery would seem to be on the table. The right-hander ended last season on the injured list with an elbow issue and has a long history of arm problems.

Jansen's velocity is down close to three mph on his cutter to begin the season, Julian McWilliams of The Boston Globe reports.

Jansen didn't get in much work during spring training due to a back issue and is still building up toward his usual form. He labored through back-to-back outings Tuesday and Wednesday, needing 20-plus pitches in each, but that he was able to pitch on consecutive days is encouraging. Jansen has converted both his save chances so far with a 0.00 ERA in three innings, albeit with a 5:5 K:BB.

Holton pitched two scoreless innings of relief in the second game of Thursday's doubleheader against the Mets. He allowed a hit and struck out one.

Holton has now logged 4.1 scoreless innings with six strikeouts across three appearances to begin the season. The lefty doesn't seem like a top option for save chances at the moment, but it is a fluid Detroit bullpen, with Alex Lange, Jason Foley, Shelby Miller and Andrew Chafin all seemingly in the mix to close out games. For now, Holton looks like a strong setup option who could be a decent source of holds.

Miller (2-0) pitched two scoreless innings of relief to earn the win in the first game of Thursday's doubleheader against the Mets. He walked two and struck out four.

Miller has been great so far, as he's now logged six scoreless innings and six strikeouts across four appearances. While Jason Foley appears to have taken hold of the closer role for now, Miller could push his way into the role if he continues to pitch this well. The veteran righty only has one MLB save, however, which came last season with the Dodgers, so he doesn't have a ton of experience closing out games. Miller will be locked in as an excellent setup option who could see some save opportunities here and there in a fluid Detroit bullpen.

Clase set the Twins down in order during a scoreless ninth inning to earn his third save of the year Thursday.

Clase allowed a couple of hard-hit balls in the frame, though they'd both result in outs as the 26-year-old right-hander locked down his third save, tying him for the league lead in the early going. Clase took a slight step back last year, pitching to a 3.22 ERA over 72.2 innings, though he'd still wind up with a career-best 44 saves in 56 chances.

Ferguson earned a save against the Diamondbacks on Wednesday, allowing one hit and one walk while striking out two batters over two-thirds of an inning.

Yankees closer Clay Holmes couldn't convert a save chance in the bottom of the 10th inning, and he left in the bottom of the 11th with two runners on base and New York clinging to a two-run lead. Ferguson took over and struck out the first batter he faced before allowing a run-scoring single. However, Arizona had previously lost its DH spot and ran through its list of reserve hitters, so Ferguson intentionally walked catcher Gabriel Moreno to load the bases in order to get to Diamondbacks reliever Scott McGough, who was forced to hit. Predictably, McGough struck out looking, and Ferguson walked away with his first save of the campaign. The left-hander nabbed a career-high three saves with the Dodgers last season, but he's not a threat to Holmes' closer role.

Holmes (1-0) blew a save but was credited with the win Wednesday against Arizona, allowing three unearned runs on one hit and striking out one batter over 1.1 innings.

The game went into extra frames, and Holmes got the call in the bottom of the 10th after the Yankees had taken a two-run lead. He couldn't convert the save, but it would be unfair to pin the fault on him. After Holmes retired the first batter he faced on a groundout, shortstop Anthony Volpe committed a throwing error that allowed a run to score and put the tying run on second base. Holmes bounced back to retire the next batter for what should been the third out, but the runner advanced to third on what was instead out No. 2 and then scored on a Corbin Carroll infield single. Holmes returned for the top of the 11th after New York took another two-run lead and was charged with another unearned run when the inherited runner came around to score following his departure, but Caleb Ferguson was able to nail down the save and allow Holmes to emerge with the victory. Despite the chaotic outing, Holmes' ERA remains at 0.00 since all three runs against him were unearned, and he now has a victory to go along with his three saves on the campaign.

Sousa underwent surgery Wednesday for thoracic outlet syndrome and will miss the rest of the season, Matt Kawahara of the Houston Chronicle reports.

Sousa landed on the 15-day IL before the start of the season due to shoulder inflammation, though an extended absence was expected after he said the issue was nerve-related -- similar to the injury he sustained last season. The 28-year-old left-hander owns a 7.06 ERA across 29.1 career MLB innings, and he will now look to 2025 for a return to a big-league mound.

The Astros transferred Murfee (elbow) to the 60-day injured list Thursday, Matt Kawahara of the Houston Chronicle reports.

Murfee won't be able to pitch for the Astros until at least the final stages of the season after undergoing Tommy John surgery in July. His spot on the 40-man roster will be given to Miguel Diaz, who was claimed off waivers from Detroit in a corresponding move.