O'Brien yielded two hits in a scoreless frame to pick up his first hold of the season in Saturday's extra-inning win over the Rays.

O'Brien was first out of the bullpen for the Cardinals in the seventh inning, called upon to protect a two-run lead after Michael McGreevy spun six no-hit frames. Junior Caminero broke up the combined no-hit effort by singling on the first pitch he saw but was immediately erased with a double play. O'Brien then yielded an infield single but finished off the inning with a groundout. The 31-year-old has now registered a win and a hold in his first two appearances, but the first two save chances for the Cardinals have gone to Ryne Stanek.

Seabold tossed 2.1 scoreless innings of relief in Saturday's 3-0 loss to the Padres. He allowed one hit and struck out three.

After Detroit starter Jack Flaherty allowed three runs (two earned) while covering only 4.1 innings, Seabold was needed to cover a few frames. The righty looked sharp across 50 pitches in his team debut, and he managed to keep the Tigers in the game after Flaherty's ineffective outing. It looks like Seabold, who has made 19 starts at the MLB level in his career, will be tasked with a long-relief role in Detroit.

Watson allowed three walks while striking out one over 2.1 hitless and scoreless innings in Saturday's 6-5 extra-innings loss to Cincinnati.

Watson, a Rule 5 pick, made his major-league debut in the sixth inning in a not so low-leverage situation. The Red Sox were trailing by two runs when the rookie entered with two outs and two runners on. After walking the first batter he faced, Watson twice thought he'd struck out Eugenio Suarez on called third strikes and walked off the mound, but both calls were challenged and overturned. The right-hander eventually gathered himself and got the slugger to ground out to second base before working scoreless seventh and eighth innings. Despite the tension surrounding Saturday's appearance, Watson is expected to remain in a low-leverage role.

Estevez had X-rays come back negative on his left ankle after being struck by a comebacker during Saturday's loss to Atlanta, Anne Rogers of MLB.com reports.

The right-hander blew the save in his season debut, surrendering six runs on four hits and two walks in one-third of an inning. With the X-rays returning negative, the injury is now a secondary concern for the Royals and Estevez, who averaged just 91.2 mph with his fastball Saturday, down nearly five ticks from last season. The horrid outing doubled his worst performance from 2025, in which he gave up three runs. Estevez will likely have some leash as Kansas City's closer after recording 42 saves with a 2.45 ERA last year, but that leash is likely to be shorter if the velocity woes continue.

Sewald retired the lone batter he faced in the eighth inning of Saturday's 3-2 loss to the Dodgers.

Arizona led 2-1 in the eighth inning with Sewald warming up in the bullpen, presumably to save the game in the ninth, but he never got the chance after Juan Morillo allowed a two-run home run, setting up Sewald to get the final out of the inning in a non-save situation. It was the veteran right-hander's first appearance of the season.

Brogdon earned a save against Seattle on Saturday, allowing two runs (one earned) on one hit while striking out two batters in one inning.

Closer Cade Smith blew a save opportunity in the ninth, pushing the game into bonus time. Cleveland struck for three runs in the top of the 10th, and the Guardians chose to turn to Brogdon in the bottom of that frame. The right-hander made things interesting by serving up a two-run homer to Luke Raley, but Brogdon was able to convert the save by striking out the subsequent two batters he faced. Fantasy managers need not read into Brogdon's chance to close Saturday, as Smith isn't likely to move out of the closer role anytime soon.

Diaz earned the save against the Diamondbacks on Saturday with a perfect inning of work.

The Dodgers took their first lead with two outs in the bottom of the eighth inning, giving Diaz an opportunity for his second save. The star reliever wasn't overpowering -- all three of the outs he recorded came on flyouts, and Diaz didn't get any swinging strikes -- but he was nonetheless able to slam the door shut on 10 pitches. With Los Angeles humming to a 3-0 start and Diaz the team's clear-cut closer, he's a logical pick to be among MLB's save leaders throughout the campaign.

Vasquez (1-0) earned the win over Detroit on Saturday, pitching six scoreless innings and allowing two hits and three walks while striking out eight batters.

San Diego's offense remained mostly stagnant, but Vasquez made sure that didn't matter by blanking the Tigers over his six frames. The right-hander also had his swing-and-miss stuff working, notching 13 whiffs and eight punchouts. The latter total was more than Vasquez had in all but one of his 28 outings last season, and he promisingly averaged 95.0 mph on his fastball after averaging 93.4 mph on the pitch last year. If he's able to maintain the uptick in velocity and build on Saturday's excellent start, Vasquez could prove to be a fantasy steal for managers who selected him near the end of drafts or plucked him off the waiver wire.

Soto walked one and struck out three across 1.1 scoreless innings Saturday against the Mets.

Soto has appeared in each of Pittsburgh's first two games of the season and has racked up five strikeouts across 2.1 innings of work. He entered the game with two outs in the seventh inning and also worked around a leadoff walk to complete the eighth frame. Soto could figure into save chances this season, though Dennis Santana did follow him into the game in the ninth inning on Saturday.

Santana allowed one walk but no hits across one scoreless inning in Saturday's game against the Rockies.

Santana has pitched in both of Pittsburgh's games to begin 2026, and he has yet to allow an earned run. His usage Saturday was particularly notable, as he entered the game in the ninth inning with the score knotted at 0-0. Manager Don Kelly noted shortly before the new season began that Santana may not get every save chance, though Santana's clearly still a high-leverage arm for the Pirates and should work in plenty of save situations.