Perez gave up two hits, including a solo home run, in two-thirds of an inning Wednesday to record his first hold of the season in an extra-inning loss to the Phillies.

The 29-year-old lefty entered the game with two outs in the seventh inning and retired Kyle Schwarber, but Bryce Harper then took Perez deep to lead off the eighth as the Nationals' bullpen squandered a 5-0 lead. Perez may not hang onto a high-leverage role much longer if he can't keep the ball in the park -- he's served up two homers in his first three appearances and 2.2 innings this season, although his 3:0 K:BB is more promising than his 6.75 ERA.

Wiemer went 2-for-4 with a walk and two runs scored in Wednesday's extra-inning loss to the Phillies.

The 27-year-old continued his blistering start to the season. Wiemer has started five of the Nationals' first six games and racked up a .588/.682/1.059 slash line in 22 plate appearances with a triple, two homers, four RBI, seven runs and a 5:4 BB:K. Nothing in Wiemer's track record suggests he'll keep up anything close to that pace -- he sports a career 29.2 percent strikeout rate against an 8.6 percent walk rate in the majors -- but he's providing exceptional production so far for deep-league fantasy GMs who took a chance on him.

Semien went 0-for-4 with a walk and two strikeouts in Wednesday's extra-innings loss to the Cardinals.

The 35-year-old second baseman missed chances to play hero for the Mets in both the ninth and 11th innings, recording the final out with runners in scoring position each time. Semien is struggling to find a rhythm at the plate to begin his first season in New York, going 2-for-20 with a double, two RBI and a 3:8 BB:K through six games, but his still-excellent defense will keep him in an everyday role for now and provide him with plenty of leash to figure things out.

The Pirates will call up Griffin from Triple-A Indianapolis prior to their home opener Friday versus the Orioles, Jason Mackey of MLB.com reports.

Griffin came up just short for an Opening Day roster spot, but he will make his major-league debut as the Pirates kick off their first homestand of the season. The Pirates and Griffin have had discussions about a long-term contract extension for the 19-year-old, but while those talks will continue, Mackey says there is not currently a deal in place. Arguably the top prospect in baseball, Griffin has hit .438 with a 1.196 OPS and a 5:4 BB:K in the early going at Indianapolis. He slashed .333/.415/.527 with 21 home runs and 65 stolen bases across three levels in his first professional season in 2025. Griffin will take over at shortstop in Pittsburgh, shifting Jared Triolo either to third base or into more of a utility role.

Pauley went 2-for-4 with two doubles and a run scored in Wednesday's win over the White Sox.

The 25-year-old played his part in a 10-0 rout, collecting his first extra-base hits of the season. With Christopher Morel (oblique) and Kyle Stowers (hamstring) on the shelf and Griffin Conine (illness) unavailable as well Wednesday, Pauley got the start at first base while Connor Norby was the DH and Javier Sanoja handled the hot corner. As Pauley puts his spring forearm injury further behind him and gets back up to speed, however, he could emerge as the Marlins' preferred option at third base against right-handed pitching. Through five games to begin the season, he's gone 3-for-13 with a run scored, an RBI and a 0:5 BB:K.

Sanoja went 2-for-4 with a double and two RBI in Wednesday's rout of the White Sox.

Miami's offense didn't need to do much with Sandy Alcantara twirling a shutout, but it broke out for 10 runs anyway, with Sanoja being one of four Marlins with multiple hits. The 23-year-old utility player has seen most of his action at third base in the early going as Connor Norby has been needed elsewhere, and Sanoja's taken advantage of his opportunities by going 7-for-12 (.583) with two doubles, three RBI and a run scored.

Tawa started in left field and went 1-for-3 with a double in Wednesday's 1-0 win over Detroit.

Arizona manager Torey Lovullo loaded up the lineup with righties against tough Detroit lefty Tarik Skubal. Alek Thomas was on the bench while Jordan Lawlar (center field) and Tawa were in the outfield. Tawa wears many gloves on the diamond and will toggle between infield and outfield for the Diamondbacks. Wednesday was his second start of the season and first in the outfield. He also served as the DH on Opening Day when Pavin Smith (elbow) was scratched.

Fernandez started at first base and went 0-for-3 in Wednesday's 1-0 win over the Tigers.

Fresh off a boffo MLB debut Tuesday, when Fernandez homered twice, the infielder was in the lineup at first base Wednesday. Fernandez played a handful of games at first base over the last two seasons in the minors but primarily lined up at shortstop and third base. With Pavin Smith (elbow) on the 10-day injured list, there are at-bats available for Fernandez.

Winn was involved in a single-car accident in St. Louis on Wednesday but did not suffer serious injuries, Derrick Goold of the St. Louis Post-Dispatch reports.

The Cardinals released a statement saying Winn's accident was caused by wet pavement. He was examined at a nearby hospital before being sent home. The incident occurred shortly after Winn delivered a walk-off RBI single in the Cardinals' extra-innings win over the Mets. St. Louis is idle Thursday before opening a road trip in Detroit on Friday. The club will re-evaluate Winn prior to Friday's contest before determining his availability. It's been a rough start to the season offensively for Winn, who is 4-for-25 with one stolen base and a 2:5 BB:K in his first 27 plate appearances.

Lowe served as the designated hitter and went 1-for-2 with a double and an RBI in Wednesday's 8-3 loss to the Pirates.

Lowe made his first start of the season and managed to contribute against Pittsburgh righty Paul Skenes. When the left-handed Mason Montgomery relieved Skenes in the sixth inning, Lowe was replaced by a pinch hitter. With the hot-hitting Sal Stewart at first base and Eugenio Suarez at DH, there haven't been many opportunities for Lowe early in the regular season.