Brissett completed 22 of 44 pass attempts for 258 yards and two touchdowns while gaining 31 yards on four carries and losing two fumbles in Sunday's 44-22 loss to Seattle.

Brissett's improbable victory over the Cowboys last week was put out of mind after Arizona was greeted by the Seahawks with a 35-0 deficit in the first half. The veteran signal-caller salvaged his day by compiling stats in garbage time, producing his fourth straight start of 250 or more passing yards and two touchdowns thrown. Brissett has great shot at extending his streak of fantasy production against an injury-riddled 49ers defense next Sunday.

Jones completed 33 of 39 pass attempts for 319 yards, three touchdowns and one interception while gaining three yards on one rush attempt in Sunday's 42-26 loss to the Rams.

Jones made another start under center for the injured Brock Purdy (toe), and the results were positive from a fantasy perspective. It was Jones' third spot-start in which he threw for more than 300 yards, and the second in which he recorded three touchdown passes. After the loss, head coach Kyle Shanahan hinted that Purdy could be ready to return in Week 11, which would put an end to Jones' run as a startable option in fantasy. Managers should hold until an official announcement is made ahead of next Sunday's tilt against the Cardinals, as Jones has been exceeding expectations as the 49ers' starter.

Stafford completed 24 of 36 pass attempts for 280 yards and four touchdowns while taking three kneeldowns in Sunday's 42-26 win over San Francisco.

Stafford's second touchdown strike was the 400th touchdown pass of his decorated career, as he became just the ninth quarterback in NFL history to reach that mark. The 37-year-old kept making history by becoming the first signal-caller to record at least four touchdown passes with no interceptions over three consecutive contests. Stafford's 25 touchdown passes represent his highest mark since the 41 he threw in the regular season the year the Rams won Super Bowl LVI. The 2009 first-overall pick is playing some of the best ball of his career heading into a crucial home tilt against the 7-2 Seahawks next Sunday.

Darnold completed 10 of 12 pass attempts for 178 yards, one touchdown and one interception while losing two fumbles in Sunday's 44-22 win over Arizona.

It was a peculiar stat line from Darnold after he completed 83 percent of his attempts while committing three turnovers in a massive victory. Seattle's rushing attack (two touchdowns) and defense (two touchdowns) did all the heavy lifting on offense outside of an impressive touchdown pass to Jaxon Smith-Njigba on the game's opening drive. Darnold has sprinkled in a couple of these duds amongst mostly standout performances through nine starts. Fantasy managers should feel confident about a bounce-back game from Darnold in Week 11 when the Seahawks match high-octane offenses with the Rams next Sunday.

Mariota completed 16 of 22 passes for 213 yards, two touchdowns and no interceptions in Sunday's 44-22 loss to the Lions. He added five rushes for 22 yards.

The Commanders ran a relatively conservative offense, but Mariota performed well when given a chance. He completed three long passes of at least 30 yards while also delivering a pair of short touchdown passes. Mariota has also topped 20 rushing yards in every game in which he's attempted a pass this season. He'll draw a relatively favorable Week 12 matchup against the Dolphins, with Jayden Daniels (elbow) remaining sidelined.

Goff completed 25 of 33 passes for 320 yards, three touchdowns and zero interceptions in Sunday's 44-22 win over the Commanders.

Goff topped 300 yards for the second time this season thanks to a particularly efficient performance. In addition to completing more than 75 percent of his passes, Goff tallied three gains of more than 20 yards while throwing for a pair of 14-yard touchdowns and one of nine. Goff now has multiple passing scores in six of his nine games on the campaign, and he's averaged more than 7.5 yards per attempt in three straight matchups.

Head coach Kyle Shanahan said after Sunday's 42-26 loss to the Rams that Purdy (toe) has a real chance to return in Week 11 against the Cardinals, Ian Rapoport of NFL Network reports.

Mac Jones made his eighth start of the season in Sunday's loss to the Rams, which dropped the 49ers to 6-4. Purdy has been progressing in his recovery from turf toe and was a limited participant in Week 10 prior to being declared inactive against the Rams. Purdy would likely need to ramp up to full participation prior to reclaiming the starting role.

McCarthy completed 20 of 42 passes for 248 yards, one touchdown and two interceptions in Sunday's 27-19 loss to the Ravens. He added five rushes for 48 yards.

McCarthy started the game well, leading the Vikings to an opening-drive touchdown, primarily on the strength of a 62-yard completion to Jalen Nailor. However, it was an up-and-down performance from there, as he turned the ball over twice in three possessions spanning late in the second quarter to early in the third quarter, changing the trajectory of the game. On the other hand, he had three completions of at least 20 yards while also racking up a season-high 48 rushing yards. McCarthy is likely to remain inconsistent considering he has only four career starts, though he has a positive matchup in Week 11 against Chicago.

Mills completed 27 of 45 passes for 292 yards and two touchdowns with one interception in Sunday's 36-29 win over the Jaguars. He added 20 rushing yards and a TD on three carries.

Making his first start of the season with C.J. Stroud (concussion) unavailable, Mills struggled through three quarters before coming to life in the fourth, hitting Jayden Higgins and Dalton Schultz for TDs before running in a 14-yard score of his own to complete a stunning comeback from a 29-10 deficit. Mills could return to the bench in Week 11 against the Titans if Stroud gets cleared to return, but if he gets a second start he likely won't need to be quite as busy.

Mayfield completed 28 of 43 passes for 273 yards with three touchdowns and no interceptions in the Buccaneers' 28-23 loss to the Patriots on Sunday.

Mayfield's final numbers were certainly appealing from a fantasy perspective, although some of the yardage came on a last-ditch drive that he capped off with his final touchdown pass of the day, an 11-yard strike to Tez Johnson. That play was preceded by 21- and 10-yard TDs to Emeka Egbuka and Johnson, respectively, giving Mayfield his first three-touchdown-pass tally since Week 1. The veteran signal-caller's numbers were all the more impressive considering the ongoing absences of Mike Evans (IR, collarbone/concussion), Chris Godwin (fibula) and Bucky Irving (shoulder/foot), and he figures to once again shoulder a heavy workload through the air when the Buccaneers face the Bills on the road in Week 11.