NFL Player News

McCaffrey (Achilles) is not present at the portion of Friday's practice open to the media, Nick Wagoner of ESPN.com reports.

McCaffrey logged limited sessions Wednesday and Thursday, but it appears his activity level may be in line to regress Friday. 49ers GM John Lynch said Friday morning that he was uncertain whether McCaffrey would be cleared to suit up Sunday against Minnesota on the road, and head coach Kyle Shanahan will address the media later this afternoon. Jordan Mason enjoyed a breakout performance Week 1 with McCaffrey sidelined, while wide receiver Deebo Samuel also was tasked to handle extra backfield slack and logged eight carries.

Jacobs (back) doesn't have an injury designation for Sunday's game at Indianapolis.

Jacobs was a limited practice participant Wednesday through Friday, after playing 72 percent of snaps and taking 18 touches for 104 yards from scrimmage in the Week 1 loss to Philadelphia. He could be even more emphasized in Green Bay's offense if QB Jordan Love (questionable, MCL sprain) ends up inactive this Sunday, but that might also lead to fewer scoring opportunities for the team and less defensive focus on stopping passes.

Blackshear (personal) is listed as questionable ahead of Sunday's game against the Chargers.

Blackshear missed practice both Thursday and Friday due to a personal matter, but according to the Panthers' injury report, he still has a chance to suit up Sunday. If the 26-year-old running back isn't able to play in Week 2, expect rookie Xavier Legette to assume Carolina's top kick and punt return duties, per Joe Person of The Athletic.

Johnson rushed once for minus-1 yard and added one catch for 33 yards on two targets in Thursday's 31-10 win over the Dolphins.

Johnson watched James Cook score three first-half touchdowns, while rookie Ray Davis got most of the mop-up duty with the game out of reach, finishing with nine carries to Johnson's one. While it's a positive that Johnson is no longer bothered by the knee injury he picked up in the season opener, he seems to have fallen to third on Buffalo's running-back depth chart heading into a Week 3 visit from the Jaguars.

Pierce (hamstring) is not present at the portion of Friday's practice open to the media, Jonathan M. Alexander of the Houston Chronicle reports.

Pierce popped up on the injury report Thursday as a limited practice participant, and it looks like he'll be downgraded to DNP on Friday. That bodes poorly for the backup running back's chances of suiting up Sunday night versus the Bears. Joe Mixon is firmly entrenched as Houston's starter, but Dare Ogunbowale, British Brooks and Cam Akers will all be options to pick up depth snaps if Pierce can't go.

Wilson (oblique) has avoided a major injury after being forced off the field late in Thursday's 31-10 loss to the Bills, Ian Rapoport of NFL Network reports.

Wilson avoiding a serious health concern is one bright spot for Miami's offense, which is treading uncertain waters following the placement of quarterback Tua Tagovailoa into the concussion protocol. The team could have to rely on Skylar Thompson under center Week 3 versus the Seahawks, by which time Raheem Mostert (chest) might be a candidate to retake the field. Wilson didn't log a carry before being ruled out Thursday versus Buffalo, though he did secure both of his targets for 12 yards.

49ers GM John Lynch said Friday morning that he doesn't know if McCaffrey (Achilles) will play Sunday at the Vikings, Cam Inman of The San Jose Mercury News reports.

"Dealing with Achilles tendinitis, [it] could be good one day and then it flares," Lynch said. "Been frustrating. We're thinking in long view. We need Christian healthy, fully out there and don't want to compromise anything." Lynch's comments suggest McCaffrey is headed for another questionable designation, after being listed that way last week and ultimately missing Monday's win over the Jets. Jordan Mason filled in with 28 carries for 147 yards and a TD on an 81 percent snap share in the 32-19 victory, with WR Deebo Samuel also getting some snaps as a running back and matching his career high of eight carries.

Davis rushed nine times for 29 yards and brought in his only target for minus-1 yard in the Bills' 31-10 win over the Dolphins on Thursday night.

Davis finished with just two fewer carries than top back James Cook, although game script did have a modest part to play in that. However, it's worth noting Davis logged his first three carries on Buffalo's fourth possession in the second quarter, already matching the total he'd received in all of the Week 1 win over the Cardinals. Davis is trusted enough to serve as Cook's primary backup, and he could once again fill a solid complementary role in a Week 3 home matchup against the Jaguars on Monday, Sept. 23.

Achane rushed 22 times for 96 yards and secured all seven targets for 69 yards and a touchdown in the Dolphins' 31-10 loss to the Bills on Thursday night.

Achane was the biggest part of the Dolphins offense on a troublesome night overall that saw Tua Tagovailoa exit with a concussion late in the third quarter. Miami struggled to move the ball all night even when Tagovailoa was in the contest, with the notable exception of the majority of times it was in Achane's hands. The explosive second-year pro scored his team's only touchdown on a five-yard reception in the first quarter, and he handled a career-high 22-carry workload well in the absence of Raheem Mostert (chest). Achane also has encouragingly drawn 14 targets over the first two games and caught all of them while averaging 10.4 yards per grab. Irrespective of who's under center, the heavy usage should continue for arguably the Dolphins' best all-around offensive player in a Week 3 road matchup versus the Seahawks on Sunday, Sept. 22.

Cook rushed 11 times for 78 yards and two touchdowns and secured his only target for a 17-yard score in the Bills' 31-10 win over the Dolphins on Thursday night.

As the three-touchdown total and the 7.1 yards per carry figure substantiates, Cook was a one-man wrecking crew on the offensive side of the ball for the Bills in the lopsided victory. The third-year back opened the scoring with a 17-yard touchdown reception to cap off Buffalo's opening possession, and he added scoring runs of one and 49 yards in the second quarter. The fact the Bills already had a two-touchdown lead by halftime allowed head coach Sean McDermott to take it easy on Cook in the second half, with rookie backup Ray Davis nearly matching him in carries (nine) by night's end. Cook has 149 rushing yards and 49 receiving yards through two games heading into a Week 3 home matchup against the Jaguars on Monday, Sept. 23.