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James Cook III RB | BUF
Bills' James Cook: Missing practice Wednesday
Cook won't practice Wednesday due to foot and toe injuries, Maddy Glab of the Bills' official site reports.
According to Alaina Getzenberg of ESPN.com, Cook is banged up coming out of last week's loss to Houston and now falls into the day-to-day category ahead of Monday's game against the Jets. Look for added context regarding Cook's status to arrive no later than Thursday, when the Bills will post their first official Week 6 injury report. While Cook is sidelined for at least Wednesday's session, Ty Johnson and Ray Davis are next up for reps out of the backfield.
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Jonathan Taylor RB | IND
Colts' Jonathan Taylor: Not practicing to begin Week 6
Taylor (ankle) won't practice Wednesday, James Boyd of The Athletic reports.
Taylor, who missed this past Sunday's 37-34 loss to the Jaguars, has two more chances to return to practice ahead of this weekend's game against the Titans. If the running back is forced to miss a second straight game, Trey Sermon and Tyler Goodson would be in line to share backfield duties for the Colts in Week 6.
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Ray Davis RB | BUF
Bills' Ray Davis: Minimal usage in loss
Davis caught one of his two targets for four yards in Sunday's 23-20 loss to the Texans.
Davis was barely involved in Sunday's contest, playing just two of the Bills' 61 offensive snaps. The rookie running back failed to see a single carry for the first time this season. Davis' minimal involvement makes him nothing more than a handcuff to James Cook going forward. The 24-year-old will hope to be expand his usage in Week 6 when the Bills visit the Jets.
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Jamaal Williams RB | NO
Saints' Jamaal Williams: Plays minimal role in loss
Williams tallied two rushes for nine yards during Monday's 26-13 defeat versus the Chiefs.
Williams logged five or fewer touches for the third game in a row. The 29-year-old running back has not seen significant playing time since the Week 2 blowout versus Dallas, as Alvin Kamara has shouldered most of the workload even while Taysom Hill has been injured over the last three weeks. Williams saw more usage as a kickoff returner over the past two weeks, but there's no signal that he'll start to get more opportunities on offense moving forward. His best odds of seeing the field will come in either blowout wins or losses.
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Zach Charbonnet RB | SEA
Seahawks' Zach Charbonnet: Totals 30 yards versus Giants
Charbonnet rushed twice for 11 yards and caught three of five targets for 19 yards in Sunday's 29-20 loss to the Giants.
Kenneth Walker recorded five carries and seven receptions for a combined 76 yards, as the Seahawks committed to the passing game with 40 pass attempts. Charbonnet hasn't played more than 41 percent of the offensive snaps in any of the three games in which Kenneth Walker started, so his reps will likely be limited again Thursday versus the 49ers.
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Myles Gaskin RB | SEA
Vikings' Myles Gaskin: Signed off practice squad
The Vikings signed Gaskin off their practice squad Tuesday.
Gaskin had appeared in each of Minnesota's first five games, seeing most of his snaps on special teams while carrying three times for minus-1 yard to go with an 11-yard reception. With Vikings head coach Kevin O'Connell labeled lead back Aaron Jones (hip) as week-to-week heading into the team's Week 6 bye, Gaskin will be on hand to provide depth behind top backup Ty Chandler if Jones is unable to play in Minnesota's next game Oct. 20 versus the Lions.
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British Brooks RB | HOU
Texans' British Brooks: Sent to injured reserve
The Texans placed Brooks (knee) on injured reserve Tuesday.
Brooks suffered a knee injury in the Texans' Week 5 win over the Bills this past Sunday. He'll now miss a minimum of four games on the IR list. Brooks appeared in all five games for Houston to open the season, logging nine offensive snaps and another 79 on special teams.
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Mike Boone RB | MIA
Mike Boone: Released by Carolina
The Panthers released Boone on Tuesday.
Boone had appeared in just two of the Panthers' first five games, logging five offensive snaps and another 34 on special teams. He rushed four times for seven scoreless yards. Boone had been serving as Carolina's RB4 behind Chuba Hubbard, Miles Sanders and Raheem Blackshear. Boone is now 29 years old and will look for work elsewhere, though he's also a candidate to go to Carolina's practice squad.
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Royce Freeman RB | CHI
Royce Freeman: Let go by Cleveland
The Browns released Freeman from their practice squad Tuesday.
Freeman spent three-plus weeks on Cleveland's practice squad, but with Nick Chubb (knee, PUP) and Nyheim Hines (knee, NFI) practicing and nearing a return coupled with Pierre Strong's return to health made Freeman expendable. The 28-year-old Freeman will look for an opportunity elsewhere.
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Aaron Jones RB | MIN
Vikings' Aaron Jones: Week-to-week with hip injury
Vikings head coach Kevin O'Connell said Tuesday that Jones (hip) "continues to be evaluated" and is considered week-to-week, Alec Lewis of The Athletic reports.
Jones suffered a right hip injury in Sunday's 23-17 win over the Jets in London and missed the final three quarters of the contest. The Vikings' Week 6 bye arrives at an ideal time for Jones, but even though O'Connell said that initial indications are that the running back has avoided a long-term injury, he still could be at risk of sitting out a Week 7 matchup with the Lions on Oct. 20. After Jones left Sunday's game, Ty Chandler took on a near-every down role en route to a season-high 14 carries for 30 yards while adding two catches for nine yards. Myles Gaskin briefly mixed in, handling two carries for two yards and one catch for 11 yards.