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Cam Skattebo RB | NYG
Giants' Cam Skattebo: Tops 100 scrimmage yards in loss
Skattebo carried the ball 15 times for 59 yards and caught six of seven targets for 45 yards in Sunday's 26-14 loss to the Saints.
The rookie RB topped 100 scrimmage yards for the second time in the last three games, but Skattebo's performance was marred by a lost fumble in the red zone that New Orleans safety Jordan Howden returned 86 yards for a TD -- the third of five straight Giant possessions that ended in a turnover. Skattebo is locking down the top job in the New York backfield while Tyrone Tracy (shoulder) is sidelined, and over those last three contests he's racked up 315 scrimmage yards and a rushing touchdown. Even if Tracy remains on the shelf in Week 6, Skattebo will face a tough test against the Eagles.
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Jayden Daniels QB | WAS
Commanders' Jayden Daniels: Secures victory in return Sunday
Daniels completed 15 of 26 pass attempts for 231 yards and a touchdown while rushing for 39 yards on eight attempts in Sunday's 27-10 win over the Chargers.
Daniels returned from a two-week absence due to a knee injury in order to lead his team to its third win of the season. The 24-year-old was sporting a brace on his left knee, but it did not appear to limit the quarterback's mobility on any of his eight carries Sunday. Daniels is averaging 221.3 passing yards and 41.3 rushing yards with four touchdowns to no interceptions in three 2025 starts. The dual-threat sophomore could be primed for his finest fantasy outing under the bright lights of Monday Night Football in Week 6 when the Commanders host a Bears defense that is surrendering 389.0 yards of offense to opponents this season.
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Bryce Young QB | CAR
Panthers' Bryce Young: Helps lead comeback Sunday
Young completed 19 of 30 passes for 198 yards with two touchdowns and one interception while adding three carries for one yard in the Panthers' 27-24 win over the Dolphins on Sunday. He also lost a fumble.
Carolina managed to pull off a comeback from a 17-0 deficit, but Young had an uneven day that included three sacks in addition to his two turnovers. Rico Dowdle also helped carry the offense with his 206-yard, one-touchdown effort, but Young played a key part with a seven-yard touchdown pass to Xavier Legette that kickstarted the rally late in the first half, and he added a four-yard toss to Mitchell Evans that proved to be the game-winning score. Young has thrown for under 200 yards in all but one game this season, so even with the encouraging team result for the Panthers on Sunday, he remains a somewhat shaky fantasy option even in a favorable Week 6 home matchup against the Cowboys.
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Omarion Hampton RB | LAC
Chargers' Omarion Hampton: Leaves stadium in walking boot
Hampton (ankle) was spotted in the locker room with a walking boot on his left foot following Sunday's loss to the Commanders, Daniel Popper of The Athletic reports.
Hampton was injured in the fourth quarter against Washington and was unable to finish the contest. The Chargers already lost Najee Harris to a season-ending torn Achilles in Week 3, and it now appears Hampton will be nursing an ankle injury this week ahead of next Sunday's date with the Dolphins. If Hampton can't play against Miami, the Chargers will be down to Hassan Haskins and practice squad members Kimani Vidal and Amar Johnson.
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Bo Nix QB | DEN
Broncos' Bo Nix: Helps lead road upset Sunday
Nix completed 24 of 39 passes for 242 yards with a touchdown and no interceptions while adding three rushes for 22 yards in the Broncos' 21-17 win over the Eagles on Sunday. He also threw a two-point conversion pass.
Nix had his fair share of struggles against the Eagles' talented defense, but he helped lead Denver back from a 17-3 second-half deficit. Nix led a trio of fourth-quarter scoring drives, capping one of them with an 11-yard touchdown pass to Evan Engram and following it up with a two-point conversion toss to Troy Franklin. Nix has at least one touchdown pass in every game thus far this season and has posted his two highest passing yardage totals of the campaign in the last pair of contests heading into a Week 6 trip across the pond to face the Jets in London.
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Tua Tagovailoa QB | ATL
Dolphins' Tua Tagovailoa: Three-TD day wasted Sunday
Tagovailoa completed 27 of 36 passes for 256 yards with three touchdowns and no interceptions and added one rush for five yards in the Dolphins' 27-24 loss to the Panthers on Sunday.
Tagovailoa managed well in his first game without Tyreek Hill (IR, knee), focusing a majority of his attention, as expected, on the trio of Jaylen Waddle, Darren Waller and De'Von Achane. The three pass catchers were responsible for Tagovailoa's three TD tosses and 17 of his completions overall. The 2020 first-round pick has multiple touchdown passes in four straight games -- and Sunday's tally was a season high -- but with Miami at 1-4, the overall long-term outlook for the Dolphins is bleak. A Week 6 home matchup against the Chargers could be an uphill battle for the short-handed offensive unit as well, even when factoring in Los Angeles' struggles against the Commanders in Week 5.
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Baker Mayfield QB | TB
Buccaneers' Baker Mayfield: Dissects defense in late comeback
Mayfield completed 29 of 33 pass attempts for 379 yards and two touchdowns while rushing five times for 15 yards in Sunday's 38-35 win over the Seahawks.
Mayfield flirted with perfection in a masterful performance that saw him miss just four pass attempts while committing zero turnovers. The 30-year-old was especially sharp in the clutch when he led a pair of five-play drives that took up a little over one minute of game clock to give Tampa Bay the 10 points needed to secure victory. The loss of star WR Mike Evans (hamstring) hasn't hampered Mayfield and the passing offense, as the signal-caller is averaging 334.0 passing yards with a pair of touchdowns in the two games sans Evans. Mayfield will look to build off of the momentum of his cleanest outing when the Buccaneers host the 49ers next Sunday.
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Woody Marks RB | HOU
Texans' Woody Marks: Limited to seven touches
Marks rushed the ball seven times for 24 yards in Sunday's 44-10 win over the Ravens. He did not catch his only target.
Marks rotated within drives with Nick Chubb for most of the game, but he still ended up with four fewer carries. Neither back was able to get much going, and three of Marks' seven carries went for one yard or less. While it was a disappointing follow-up to what appeared to be a breakout performance in Week 5, game script didn't help as Houston pulled most of its offensive starters early in the fourth quarter.
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Emeka Egbuka WR | TB
Buccaneers' Emeka Egbuka: Career-high 163 yards in win
Egbuka finished with seven receptions on as many targets for 163 yards and a touchdown in Sunday's 38-35 win over Seattle.
Egbuka was unconscious in Sunday's thrilling victory, catching every ball thrown his way en route to a new career high in receiving yards (163). The standout rookie continued to step up in the absence of Mike Evans (hamstring), who missed his second game recovering from a Week 3 injury. Egbuka produced his second consecutive game with 100-plus yards and a trip to the end zone, proving that he can adequately fill his superstar teammate's shoes as Tampa Bay's No. 1 wideout. The Ohio State product is also proving that he can produce WR1 numbers for fantasy managers heading into a matchup against the 49ers next Sunday.
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Zay Flowers WR | BAL
Ravens' Zay Flowers: Makes one long catch
Flowers recorded five receptions on five targets for 72 yards in Sunday's 44-10 loss to the Texans.
Flowers was unsurprisingly Cooper Rush's favorite target, and he came away with a decent fantasy stat line despite the blowout loss. He did most of his damage on a deep pass down the field that went for 56 yards, with Flowers being tackled at the four-yard line to narrowly miss out on his second score of the season. Though it was an unsustainable way to get the production, Flowers has now topped 70 receiving yards in four of five games this season and will hope to get Lamar Jackson (hamstring) back for a Week 6 matchup against the Rams.