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Xavier Worthy WR | KC
Chiefs' Xavier Worthy: Operating as Chiefs' WR1
Worthy will be the Chiefs' top wideout against the Chargers on Sunday due to the absence of Rashee Rice (hamstring/knee).
Rice sustained his injuries during the Chiefs' Week 4 win against the Raiders, and the extra rest courtesy of the Week 5 bye was not enough for him to be cleared to play Sunday. Worthy finished that Week 4 contest with four catches (on seven targets) for 70 yards, and with Rice sidelined, quarterback Patrick Mahomes will rely more heavily on Worthy and veteran tight end Travis Kelce in the passing game, with Jalen Royals and rookie Cyrus Allen also in line for more playing time on offense.
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Jaelan Phillips LB | CAR
Panthers' Jaelan Phillips: Questionable for Sunday
Phillips (hamstring) is listed as questionable for Sunday's game against the Eagles.
Phillips was aiming to suit up for Week 6 but may not be quite ready to go. The linebacker was limited in the Panthers' Wednesday and Thursday sessions before upgrading to a full participant in Friday's practice. Phillips will likely play in Sunday's game against the Eagles, but there is still a chance the team will be overly cautious with the star pass rusher.
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George Pickens WR | DAL
Cowboys' George Pickens: Set for normal duties with Lamb healthy
With CeeDee Lamb (quadriceps) healthy and cleared to play Sunday night against the Packers, Pickens will handle his normal role as Dallas' WR2.
Lamb exploded for 17 catches in Week 4, but the Cowboys made a concerted effort to get Pickens more involved last Thursday night against the Bucs, as he secured nine of 13 targets for 130 yards and a touchdown. Lamb suffered a quad bruise late in the game, and it allowed Pickens to be the clear WR1 and target hog while Lamb nursed his injury on the sideline. Pickens has weekly monster box-score upside, and he can still go off for a big line even with Lamb past his bruised thigh.
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Tre Harris WR | LAC
Chargers' Tre' Harris: Out this week
Harris (hamstring) has been ruled out for Sunday's game against the Chiefs.
Harris didn't practice this week, after making an early exit from the Week 5 loss to Denver. With Ladd McConkey (foot) and Quentin Johnston (chest) now returning from injuries, the team's WR room is in better shape than a week ago even without Harris.
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D'Andre Swift RB | CHI
Bears' D'Andre Swift: Bigger workload sans Monangai
Swift will once again absorb a heavier backfield workload after Kyle Monangai (thumb/toe) was ruled out for Sunday's game against the Falcons, Larry Mayer of the Bears' official site reports.
Monangai will miss a second consecutive game due to thumb and toe injuries, leaving Swift as the clear RB1 while Roschon Johnson operates in a depth role. Swift had just 13 touches in a Week 5 loss to the Packers, though he finished with 73 yards and a touchdown, which was the Bears' only trip to the end zone. Through five regular-season games, the veteran running back has turned 78 carries into 354 yards (4.5 YPC) and four touchdowns while catching 14 of 16 passes for 114 yards.
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Ashton Dulin WR | IND
Colts' Ashton Dulin: Ruled out for Sunday
Dulin (hamstring) has been ruled out ahead of Sunday's game against the Titans, Joel A. Erickson of The Indianapolis Star reports.
Dulin was unable to participate in any Week 6 prep sessions. The wide receiver will miss a second consecutive game as he focuses on recovering from his hamstring issue. Deion Burks is set to be the No. 4 wide receiver for the Colts again.
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Case Keenum QB | CHI
Bears' Case Keenum: Unclear role for Week 6
Caleb Williams (hamstring) is listed as questionable for Sunday's game against Atlanta, but if he's not given the green light to return, then it's unclear whether Keenum or Tyson Bagent starts under center for Chicago, Larry Mayer of the Bears' official site reports.
It seems Keenum and Bagent would each have a 50-50 shot at starting Sunday if Williams isn't cleared to play, with head coach Ben Johnson saying Friday "we have two guys that are equally qualified" in reference to Keenum and Bagent. Keenum was the backup for each of the Bears' last two games, though he did take over in the fourth quarter of Chicago's Week 5 loss to Green Bay after Bagent threw his second pick of the game in the third period. Keenum was the starter and led the Bears to a Week 3 victory over the Eagles, when he completed 24 of 34 passes for 247 yards and two touchdowns while adding six yards and a score on four carries.
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Anthony Tyus III RB | CAR
Anthony Tyus: Set for Sunday elevation
The Panthers plan to elevate Tyus to the active roster ahead of Sunday's game against the Eagles, Mike Kaye of ESPN.com reports.
Tyus is set to be elevated as the team's No. 2 running back behind Chubba Hubbard due to the absence of AJ Dillon (ankle). Sunday will be Tyus' third consecutive game suiting up for the Panthers.
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Tyson Bagent QB | CHI
Bears' Tyson Bagent: Could be QB2 against Atlanta
Whether Bagent starts or serves in a backup role against the Falcons on Sunday depends largely on whether Caleb William (hamstring) is cleared to return from a three-game absence, Larry Mayer of the Bears' official site reports.
Williams strung together a trio of full practices during Week 6 prep, but he's not quite out of the woods yet as the team manages the third-year pro's hamstring injury. If Williams is not cleared to return, then it's not entirely clear whether Bagent or Keenum would get the starting nod, with head coach Ben Johnson being mum on those two options following Friday's practice. Bagent led the Bears to a Week 4 win against the Jets but was benched in the third quarter of Chicago's Week 5 loss to Green Bay after throwing a second interception.
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Antoine Winfield Jr. SAF | TB
Buccaneers' Antoine Winfield: Won't play Sunday
Winfield (ribs) has been ruled out ahead of Sunday's game against the Steelers, Brianna Dix of the Buccaneers' official site reports.
Winfield was unable to practice for a second week in a row after sustaining a rib injury in the Buccaneers' Week 4 loss to the Packers. Ifeatu Melifonwu will once again replace the star safety as he continues to recover.