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Michael Wilson WR | ARI
Cardinals' Michael Wilson: Two catches in loss
Wilson caught two of seven targets for 18 yards in Sunday's 31-7 loss to the Seahawks.
Wilson and the rest of the Cardinals' offense never got going Sunday, but he still finished second on the team in targets behind tight end Trey McBride (10) in the contest. Wilson continues to be quarterback Jacoby Brissett's favorite option at wide receiver, garnering 14 targets over the first two games of the regular season. The 26-year-old will look to find paydirt for the first time in 2026 when Arizona travels to face the 49ers in Week 3.
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Christian McCaffrey RB | SF
49ers' Christian McCaffrey: Scores twice to reach 100 career TDs
McCaffrey rushed 10 times for 23 yards and two touchdowns while catching both of his targets for 43 yards in Sunday's 35-13 win over the Dolphins.
McCaffrey opened the scoring with a one-yard touchdown run in the first quarter and added another one-yard touchdown run in the third quarter. The two-touchdown performance brought McCaffrey's career regular-season touchdown total up to 100. Exactly half of those touchdowns have come with the 49ers, as McCaffrey joins Marshall Faulk and Randy Moss as the only players to score at least 50 touchdowns apiece for multiple teams, per ESPN Insights. McCaffrey should continue to contribute as both a runner and a pass catcher in Week 3 against the Cardinals.
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Ashton Jeanty RB | LV
Raiders' Ashton Jeanty: Handles 25 touches in Week 2 upset
Jeanty rushed 21 times for 48 yards and brought in four of seven targets for 15 yards in the Raiders' 26-14 win over the Chargers on Sunday.
Jeanty was the unquestioned leader of the Raiders' ground attack once again, and although he had to scratch and claw for every yard, the second-year back helped keep the Bolts' defense honest. Jeanty also finished second in receptions and tied for the team lead in targets, underscoring how central he is to what Las Vegas does on offense. Jeanty and his teammates will be gunning for a third consecutive victory to open the season when they tangle with the equally surprising Saints on the road next Sunday.
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Stefon Diggs WR | WAS
Commanders' Stefon Diggs: Scores two more TDs in Week 2 loss
Diggs caught five of six targets for 47 yards and two touchdowns in the Commanders' 37-20 loss to the Cowboys on Sunday.
Diggs tied Rachaad White and Dyami Brown for second on the team with his six targets, three behind Terry McLaurin for the team lead. It was Diggs who accounted for both of Washington's touchdowns, securing scores from Jayden Daniels (elbow) in the second quarter before then catching one from Marcus Mariota in the fourth. Through two games with the Commanders, Diggs has nine catches for 102 yards and three touchdowns on 15 targets. His production figures to take a hit while Daniels is sidelined with his injury.
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Sam Darnold QB | SEA
Seahawks' Sam Darnold: Ahead of schedule in recovery
Darnold (glute) is ahead of schedule in his recovery and has a chance to practice ahead of Seattle's Week 3 road game against the Commanders, head coach Mike Macdonald said after Sunday's 31-7 victory over the Cardinals, Curtis Crabtree of Fox 13 Seattle reports.
Macdonald added that "the timetable has shifted quite drastically" for Darnold's recovery. It sounds like Darnold has a chance to return as soon as next Sunday, though the Seahawks have little reason to rush his return with backup QB Drew Lock having led the team to a 2-0 record. Darnold's first step toward game action would be a return to practice, and his first chance to do so will come Wednesday.
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Omarion Hampton RB | LAC
Chargers' Omarion Hampton: Mixed performance in Week 2 loss
Hampton rushed 23 times for 94 yards and a touchdown and brought in both targets for 21 yards in the Chargers' 26-14 loss to the Raiders on Sunday. He also lost a fumble.
Hampton put together a perfectly useful fantasy performance in the Chargers' alarming upset loss, spearheading Los Angeles' ground attack while handling a workhorse role. Hampton added a one-yard touchdown run in the second quarter, but his lost fumble in Raiders territory with 3:52 remaining in the game and the Bolts trying to erase a three-point deficit was a back-breaker, as it led to Las Vegas' game-clinching touchdown. Hampton has a rushing touchdown in each of the first two games of the new season but has a pair of lost fumbles as well. Nevertheless, the talented back will remain in the lead role for a Week 3 road showdown against the Bills next Sunday, a critical early-season contest for Jim Harbaugh's squad.
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Tre Tucker WR | LV
Raiders' Tre Tucker: Pops off for 119 yards, TD in win
Tucker caught five of seven targets for 119 yards and a touchdown in the Raiders' 26-14 win over the Chargers on Sunday.
With Brock Bowers (knee) missing a second straight game to open the season, Tucker matched Ashton Jeanty with a team-high seven targets against Los Angeles, and the speedy wideout got free behind the defense for a 40-yard score to open the scoring in the second quarter. One of the more boom-or-bust receivers in the sport, Tucker now has seven grabs for 146 yards and the one touchdown on 11 targets through two games to begin the 2026 campaign. He'll be in position for another big performance next Sunday in the Superdome against the Saints.
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Jayden Daniels QB | WAS
Commanders' Jayden Daniels: Coach confirms elbow dislocation
Daniels (elbow) suffered a dislocated left elbow but isn't dealing with a fracture, head coach Dan Quinn revealed after Sunday's 37-20 loss to the Cowboys, Tashan Reed of the Washington Post reports.
Daniels' injury is to the same left elbow that he dislocated in Week 9 of the 2025 season, which sidelined him for the next three games. He was hurt on the final play of the first half during Sunday's loss to Dallas and promptly ruled out for the remainder of the game. Daniels' arm bent at an awkward angle as he tried to brace himself while falling. Marcus Mariota threw for 111 yards and a touchdown after Daniels' exit, and Mariota is likely to start for the Commanders in Week 3 against the Seahawks.
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Jeremiyah Love RB | ARI
Cardinals' Jeremiyah Love: Held in check versus Seattle
Love rushed nine times for 29 yards while catching all three of his targets for 16 yards in Sunday's 31-7 loss to Seattle.
Love and the rest of the Cardinals' offense mustered only a combined 151 total yards Sunday. The running back was able to reel in multiple catches for the second straight week to open the regular season, and he saw 12 touches to Tyler Allgeier's seven in the contest. Arizona will have another tough test with a road matchup against the 49ers (2-0) in Week 3, but Love figures to continue to separate from the pack as the Cardinals' clear No. 1 option at running back moving forward.
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Derwin James FS | LAC
Chargers' Derwin James: Suffers broken pinky finger
James suffered a fractured left pinky finger in Sunday's loss to the Raiders, Kris Rhim of ESPN.com reports.
The star safety said Sunday that he'll play the remainder of the 2026 season with a cast, suggesting he doesn't plan to miss any game action moving forward. James recorded seven tackles (two solo) in the 26-14 loss to Las Vegas.