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CJ West DT | SF
49ers' CJ West: Placed on injured reserve
The 49ers placed West (undisclosed) on injured reserve Wednesday.
It remains unclear what issue is sidelining the second-year player. West will now need to miss at least four games on IR before becoming eligible to return to the active roster. The defensive tackle has logged five tackles (one solo) over 49 defensive snaps in the 49ers' first two regular-season games.
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Tyson Campbell CB | CLE
Browns' Tyson Campbell: Limited at practice Wednesday
Campbell (ankle/hip) was a limited participant at practice Wednesday, Daniel Oyefusi of ESPN.com reports.
Campbell played through his ankle issue during Sunday's win at Tampa Bay, and it's a generally encouraging sign that the hip injury that took him out of that contest early isn't keeping him off the practice field entirely. He'll likely need to quickly recover from both injuries and log a full practice Thursday or Friday to avoid carrying an injury designation into the weekend.
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Devin Lloyd LB | CAR
Panthers' Devin Lloyd: Dealing with calf injury
Lloyd (calf) did not participate at the Panthers' practice Wednesday.
Lloyd popped up on the injury report with a calf issue to open the week. The injury occurred during the first half of Sunday's 34-3 win over Atlanta, but the linebacker is not too concerned about it, per Joe Person of The Athletic. Lloyd will have two more chances to return to practice before the team travels to face the Browns in Week 3.
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Brenen Thompson WR | LAC
Chargers' Brenen Thompson: Dealing with quad issue
Thompson (quadriceps) did not participate at practice Wednesday.
Thompson drew three targets in the Chargers' loss versus the Raiders in Week 2, but it appears he may have picked up a quad injury during that contest as well. He'll probably have to return to practice Thursday or Friday to give himself a chance to play in Week 3 at Buffalo.
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T.J. Sanders DT | BUF
Bills' T.J. Sanders: DNP Wednesday
Sanders (appendix) did not participate in Wednesday's practice, Katherine Fitzgerald of The Buffalo News reports.
Sanders did not play in the Bills' Week 2 win over the Lions due to a knee injury and an illness. The defensive tackle's absence during the first practice of Week 3 came for a different reason, as Sanders' appendix was surgically removed Tuesday. It remains unclear how long it will take the 23-year-old to return to football shape.
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Malick Meiga WR | CAR
Malick Meiga: Signed to Seattle's practice squad
Meiga was signed to the Seahawks' practice squad Wednesday, John Boyle of the team's official website reports.
Seattle hosted Meiga for a tryout Tuesday, and he will now get a chance to prove himself with the team moving forward. The wide receiver was waived after reaching an injury settlement with Carolina on Aug. 12, but he has now fully recovered from an undisclosed injury.
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Sam Darnold QB | SEA
Seahawks' Sam Darnold: Officially limited to begin week
Darnold (glute) officially was a limited practice participant Wednesday, John Boyle of the Seahawks' official site reports.
Prior to Darnold returning to practice Wednesday, head coach Mike Macdonald told Brady Henderson of ESPN.com that the quarterback wouldn't take every rep, his activity level is expected to increase as the week continues, and the team will make a decision between Darnold and Drew Lock as the Week 3 starter by Friday. Darnold then was seen throwing while stretching during the media-access portion of Wednesday's session, per Gregg Bell of The Tacoma News Tribune. Darnold is seeking his first game action since straining his glute on Seattle's fifth offensive snap of the season on Sept. 9 against the Patriots.
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Jadarian Price RB | SEA
Seahawks' Jadarian Price: Limited Wednesday
Price (chest) practiced in a limited fashion Wednesday, John Boyle of the Seahawks' official site reports.
When Price exited this past Sunday's win at Arizona, he was deemed questionable to return due to a chest issue. Coach Mike Macdonald termed Price's injury as to his shoulder Monday, per Brady Henderson of ESPN.com, but the initial Week 3 practice report again called it a chest concern. In any case, Price is kicking off the week with some activity and will have two more chances to increase his workload as Seattle preps for Sunday's visit to Washington. Emanuel Wilson and George Holani are available in the event Price is inhibited or sidelined this weekend.
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Javon Kinlaw DT | WAS
Commanders' Javon Kinlaw: Misses practice Wednesday
Kinlaw (shoulder) did not practice Wednesday, John Keim of ESPN.com reports.
Head coach Dan Quinn said Monday that Kinlaw is battling a shoulder injury and will need an MRI. Nothing has been revealed since, so it's unknown if his absence from practice was for precautionary reasons. If Kinlaw can't suit up Sunday versus the Seahawks, it could mean more work for Charles Omenihu and Shy Tuttle.
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Noah Sewell LB | CHI
Bears' Noah Sewell: Bears open practice window
The Bears opened the 21-day practice window for Sewell (Achilles) on Wednesday, Kevin Fishbain of The Athletic reports.
Sewell began the 2026 campaign on the reserve/PUP list while working his way back from a torn Achilles. Although that means he is required to miss at least two more games, it appears he is moving in a positive direction toward a return. The 24-year-old most recently appeared in 13 regular-season games for Chicago during the 2025 campaign, amassing 59 total tackles and one forced fumble.