San Francisco placed Collins (knee) on injured reserve Thursday.
This move was anticipated, as Collins is set to miss the entire 2026 campaign as a result of tearing his patellar tendon during practice Tuesday. Osa Odighizuwa, CJ West and Gracen Halton should get plenty of reps at defensive tackle with Collins and Sam Okuayinonu (foot) sidelined.
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49ers' Alfred Collins: Suffers torn patellar tendon, out for 2026
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Collins will miss the entire 2026 season after suffering a torn patellar tendon during Tuesday's practice, Nick Wagoner of ESPN.com reports.
The loss of Collins is another big blow to the 49ers' defensive front, as Sam Okuayinonu is scheduled to undergo surgery this weekend for a broken foot. Collins will eventually be placed on injured reserve, and the 2025 second-rounder will shift his focus toward being fully healthy for the start of the 2027 campaign. With rookie fourth-rounder Gracen Halton (ankle) and James Thompson (hamstring) also dealing with injuries, Osa Odighizuwa and CJ West are the only healthy defensive tackles on the 49ers' roster heading into Thursday's regular-season opener against the Rams in Melbourne, Australia.
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49ers' Alfred Collins: Dealing with knee injury
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Collins (knee) was a limited participant at the 49ers' practice Tuesday, Matt Maiocco of NBC Sports Bay Area reports.
Collins is dealing with an apparent knee injury ahead of the team's regular-season opener, but considering he was able to practice in any capacity, it is likely a minor issue. The defensive lineman will have a chance to erase any doubt about his availability to play in Week 1 by logging a full practice Wednesday.
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49ers' Alfred Collins: Removed from PUP list
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The 49ers activated Collins (shoulder) from the active/PUP list Friday after he passed a physical, Jennifer Lee Chan of NBC Sports Bay Area reports.
Collins was working through a shoulder injury during the offseason, but he's now healthy enough to participate in practices. The 2025 second-rounder played in 16 regular-season games in his rookie year, finishing with 17 tackles (four solo), including 1.0 sacks, two pass defenses, two forced fumbles and two fumble recoveries.
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49ers' Alfred Collins: Lands on PUP list
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The 49ers placed Collins (shoulder) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports.
Collins picked up a shoulder injury earlier in the offseason and will now be sidelined until he's activated off the PUP list. The 2025 second-round pick is coming off a solid rookie campaign with 1.0 sacks, two forced fumbles and two fumble recoveries and is expected to serve as the team's starting nose tackle during the 2026 season.
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49ers' Alfred Collins: Will play against Arizona
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Collins (hip) does not carry an injury designation into Sunday's game against the Cardinals.
Collins was a full participant in Friday's practice, and his lack of an injury tag puts him on track to return Sunday from a one-game absence due to a hip injury. His return means there will be less rotational snaps at defensive tackle available for Kevin Givens, Jordan Elliott and CJ West. Collins has accumulated eight tackles (two solo), one forced fumble and two fumble recoveries across nine regular-season games.
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49ers' Alfred Collins: Won't play Week 10
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Collins (hip) is inactive for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.
Collins appeared on Thursday's practice report as a DNP due to a hip injury, which also prevented him from practicing Friday. The injury is severe enough for him to be sidelined for Sunday's NFC West tilt, which means there are more snaps at defensive tackle available for the likes of Jordan Elliott, Kevin Givens and CJ West. Collins will look to progress enough in his recovery to be available for Week 11 against the Cardinals on Sunday, Nov. 16.
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49ers' Alfred Collins: Lands on injury report
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Collins (hip) did not participate in Thursday's practice, Matt Barrows of The Athletic reports.
The defensive tackle was not listed on Wednesday's injury report. Collins has played in more than half the defensive snaps in each of San Francisco's last five games. Kevin Givens, Jordan Elliott and CJ West are the 49ers' reserve defensive tackles.
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49ers' Alfred Collins: Set to play vs. Tampa Bay
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Collins (knee) will play in the 49ers' matchup versus the Buccaneers on Sunday, Briana Jeannel of the team's official site reports.
Collins suffered a sprained knee in the Week 5 win over the Rams but is now healthy again. The rookie second-round pick has recorded just five tackles (two solo) across his first five outings while playing on both defense and special teams. He should continue to serve as a depth option along the defensive line in Sunday's game.
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49ers' Alfred Collins: Iffy for Week 6
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Collins (knee) is questionable for Sunday's game against the Buccaneers, Greg Auman of Fox Sports reports.
Collins suffered a sprained knee in Week 5 but managed to turn in limited practices both Thursday and Friday. He appears to be truly questionable for Week 6, and his status will be important given that he's logged a minimum of one-third of defensive snaps from Week 2 on.
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49ers' Alfred Collins: Sidelined by knee injury
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Collins (knee) did not practice Wednesday, Eric Branch of the San Francisco Chronicle reports.
Collins suffered a knee sprain in Thursday's win over the Rams, so it's not a big surprise that he was unable to practice to begin preparation for a Week 6 matchup against Tampa Bay. Kalia Davis (hand) will also be sidelined, so the 49ers' defensive line could be shorthanded.
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49ers' Alfred Collins: Back at training camp
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Collins (calf) has fully participated in practices during the 49ers' first week of training camp, Mike Maynard of The Sporting News reports.
The rookie second-rounder suffered a calf injury during minicamp in June, but he has fully recovered and is participating in practice. Although they are projected to serve as a backup behind Jordan Elliott and Kevin Givens (pectoral), Collins and fellow rookie defensive tackle CJ West are expected to see plenty of snaps on defense in 2025.
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49ers' Alfred Collins: Expects return for training camp
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Collins (calf) will be back on the practice field during training camp, Vic Tafur of The Athletic reports.
It's not entirely clear what happened to Collins, but at this point it doesn't seem to be anything too severe. The rookie will miss valuable learning opportunities during minicamp this week, however. As long as he's available, the 2025 second-round pick should play a notable role on San Francisco's defensive line.
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49ers' Alfred Collins: Heads west to Niners in Round 2
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The 49ers selected Collins in the second round of the 2025 NFL Draft, 43rd overall.
Collins (6-foot-6, 332 pounds) is an enormous defensive tackle from Texas who boasts both extreme mass and reach (34 and 5/8-inch arms), giving him the ability to occupy blockers and disrupt passing lanes with his hands. Collins might lack the range necessary to play a three-down role, however, and he could end up a rotational run-stopping specialist instead of a true starter. Collins is unlikely to emerge as an IDP option in most formats.
